PMID- 31577217
OWN - NLM
STAT- MEDLINE
DCOM- 20200403
LR  - 20220609
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 38
IP  - 2
DP  - 2020 Mar-Apr
TI  - Does psoriatic axial spondyloarthritis phenotype correlate with imaging 
      morphotype?
PG  - 329-332
LID - 10.55563/clinexprheumatol/8qh84l [doi]
AB  - OBJECTIVES: To compare the magnetic resonance imaging (MRI) morphology of 
      inflammatory and chronic lesions in the sacroiliac joints (SIJs) and spine 
      between patients with non-psoriatic and psoriatic non-radiographic axial 
      spondyloarthritis (axSpA and p-axSpA, respectively). METHODS: Patients from the 
      EMBARK trial (NCT01258738) with axSpA (n=179) and p-axSpA (n=24) who had MRI data 
      available were compared in terms of baseline demographics, clinical 
      characteristics, and the frequency (n/N [%]) and distribution of inflammatory and 
      structural SIJ and spinal lesions. RESULTS: Patients with p-axSpA were on average 
      older (35.1 years vs. 31.7 years, p=0.047), had a higher occurrence of asymmetric 
      sacroiliitis (54.2% vs. 29.6%, p=0.042), and a lower occurrence of human 
      leukocyte antigen (HLA)-B27 positivity (41.7% vs. 73.7%, p=0.010) than patients 
      with axSpA. There were no significant differences in the frequency of lesions in 
      any of the SIJ or spinal quadrants between the two subgroups. CONCLUSIONS: These 
      data suggest that differences between axSpA and p-axSpA extend beyond presence of 
      psoriasis, and include age, SI symmetry, and HLAB27 status. These findings may 
      help explain the morphotype-phenotype relationship across axSpA, similar to those 
      described in older radiographic studies.
FAU - Gensler, Lianne S
AU  - Gensler LS
AD  - University of California, San Francisco, CA, USA. lianne.gensler@ucsf.edu.
FAU - Szumski, Annette
AU  - Szumski A
AD  - Syneos Health, Collegeville, PA, USA.
FAU - Jones, Heather E
AU  - Jones HE
AD  - Pfizer, Collegeville, PA, USA.
FAU - Baraliakos, Xenofon
AU  - Baraliakos X
AD  - Ruhr University, Rheumazentrum Ruhrgebiet Herne, Bochum, Germany.
LA  - eng
PT  - Journal Article
DEP - 20191001
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adult
MH  - Female
MH  - HLA-B27 Antigen/*analysis/blood
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Phenotype
MH  - Sacroiliac Joint/pathology
MH  - *Sacroiliitis/diagnostic imaging/immunology/pathology
MH  - *Spondylarthritis/diagnostic imaging/immunology/pathology
EDAT- 2019/10/03 06:00
MHDA- 2020/04/04 06:00
CRDT- 2019/10/03 06:00
PHST- 2019/03/08 00:00 [received]
PHST- 2019/07/08 00:00 [accepted]
PHST- 2019/10/03 06:00 [pubmed]
PHST- 2020/04/04 06:00 [medline]
PHST- 2019/10/03 06:00 [entrez]
AID - 14071 [pii]
AID - 10.55563/clinexprheumatol/8qh84l [doi]
PST - ppublish
SO  - Clin Exp Rheumatol. 2020 Mar-Apr;38(2):329-332. doi: 
      10.55563/clinexprheumatol/8qh84l. Epub 2019 Oct 1.