PMID- 31578661
OWN - NLM
STAT- MEDLINE
DCOM- 20210401
LR  - 20210401
IS  - 1532-2807 (Electronic)
IS  - 1219-4956 (Linking)
VI  - 26
IP  - 3
DP  - 2020 Jul
TI  - Differential Expression and Diagnostic Significance of Pre-Albumin, Fibrinogen 
      Combined with D-Dimer in AFP-Negative Hepatocellular Carcinoma.
PG  - 1669-1676
LID - 10.1007/s12253-019-00752-8 [doi]
AB  - Hepatocellular carcinoma (HCC) is one of the most malignant cancers with high 
      morbidity and mortality. Nowadays, AFP-negative hepatocellular carcinoma 
      (AFP-NHCC) has been found in many HCC patients and AFP analysis can't be used to 
      screen HCC in these cases. In this study, we have examined the expression 
      patterns of pre-albumin (PA), fibrinogen, D-Dimer and their clinical significance 
      in AFP-NHCC. We recruited 214 AFP-NHCC patients and 210 controls in the study. 
      PA, fibrinogen and D-Dimer levels were detected by turbidimetry, clauss and 
      immunoturbidimetry methods, respectively. Serum PA levels were significantly 
      lower in AFP-NHCC (84.5 +/- 24.7 mg/L) than that in the controls 
      (240.6 +/- 59.4 mg/L, P < 0.05). For plasma fibrinogen levels, there was no 
      difference between the controls (2.9 +/- 0.7 g/L) and AFP-NHCC (2.5 +/- 0.7 g/L). 
      Compared with AFP-NHCC (0.8 +/- 0.2 mg/L), plasma D-Dimer levels were significantly 
      lower in controls (0.1 +/- 0.0 mg/L, P < 0.05). The levels of PA, fibrinogen and 
      D-Dimer were significantly correlated with differentiation (P < 0.01), and the PA 
      and D-Dimer values were correlated with TNM stage (P < 0.05). Moreover, PA levels 
      were correlated with tumor size (P = 0.034). Receiver operating characteristic 
      curve (ROC) analyses elaborated that combination of PA, fibrinogen and D-Dimer 
      possessed a higher sensitivity (93.4%) for differentiating AFP-NHCC from the 
      controls, but the diagnostic specificity was reduced due to the combination of 
      fibrinogen. After adjusting for all significant outcome predictors of the 
      univariate logistic regression analysis, low levels of PA and high levels of 
      D-Dimer were remained independent unfavorable outcome predictors (P < 0.05). Our 
      data suggested that the expression levels of PA, fibrinogen and D-Dimer played 
      critical roles in AFP-NHCC tumorigenesis. Moreover, PA and D-Dimer might be 
      considered as potential diagnostic indicators in AFP-NHCC.
FAU - Jing, Wei
AU  - Jing W
AD  - Department of Clinical Laboratory, Key Laboratory of Laboratory Medicine of 
      Henan, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, 
      China. xjw2009@yeah.net.
FAU - Peng, Ruoyu
AU  - Peng R
AD  - Department of Clinical Laboratory, Key Laboratory of Laboratory Medicine of 
      Henan, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, 
      China.
FAU - Zhu, Man
AU  - Zhu M
AD  - Department of Medical Laboratory, the Central Hospital of Wuhan, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430000, China.
FAU - Lv, Shaogang
AU  - Lv S
AD  - Department of Clinical Laboratory, Key Laboratory of Laboratory Medicine of 
      Henan, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, 
      China.
FAU - Jiang, Shitao
AU  - Jiang S
AD  - Department of Nuclear Medicine, Henan Medical Key Laboratory of Molecular 
      Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 
      450000, China.
FAU - Ma, Junfen
AU  - Ma J
AD  - Department of Clinical Laboratory, Key Laboratory of Laboratory Medicine of 
      Henan, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, 
      China.
FAU - Ming, Liang
AU  - Ming L
AD  - Department of Clinical Laboratory, Key Laboratory of Laboratory Medicine of 
      Henan, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20191002
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (Prealbumin)
RN  - 0 (fibrin fragment D)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*blood
MH  - Carcinoma, Hepatocellular/*diagnosis
MH  - Female
MH  - Fibrin Fibrinogen Degradation Products/analysis/*metabolism
MH  - Fibrinogen/analysis/*metabolism
MH  - Humans
MH  - Liver Neoplasms/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Prealbumin/analysis/*metabolism
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - AFP-negative hepatocellular carcinoma
OT  - D-Dimer
OT  - Diagnosis
OT  - Fibrinogen
OT  - Pre-albumin
EDAT- 2019/10/04 06:00
MHDA- 2021/04/02 06:00
CRDT- 2019/10/04 06:00
PHST- 2019/07/24 00:00 [received]
PHST- 2019/09/12 00:00 [accepted]
PHST- 2019/10/04 06:00 [pubmed]
PHST- 2021/04/02 06:00 [medline]
PHST- 2019/10/04 06:00 [entrez]
AID - 10.1007/s12253-019-00752-8 [pii]
AID - 10.1007/s12253-019-00752-8 [doi]
PST - ppublish
SO  - Pathol Oncol Res. 2020 Jul;26(3):1669-1676. doi: 10.1007/s12253-019-00752-8. Epub 
      2019 Oct 2.