PMID- 31580457
OWN - NLM
STAT- MEDLINE
DCOM- 20201201
LR  - 20201201
IS  - 1465-3664 (Electronic)
IS  - 0142-6338 (Linking)
VI  - 66
IP  - 3
DP  - 2020 Jun 1
TI  - Prevalence and Risk Factors of Allergic Bronchopulmonary Aspergillosis and 
      Aspergillus Sensitization in Children with Poorly Controlled Asthma.
PG  - 275-283
LID - 10.1093/tropej/fmz066 [doi]
AB  - BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) may be a risk factor 
      for poorly controlled asthma in children. The studies regarding prevalence and 
      risk factors of ABPA in children with poorly controlled asthma are limited in 
      number. OBJECTIVES: To determine prevalence and risk factors of ABPA and 
      aspergillus sensitization (AS) in children with poorly controlled asthma. 
      METHODS: In this prospective cross-sectional study from a tertiary care center in 
      India, we enrolled asthmatic children 5-15 years of age with poorly controlled 
      asthma. We did the following investigations: spirometry, skin prick test, serum 
      total immunoglobulin E (IgE), aspergillus-specific IgE and immunoglobulin G, 
      serum precipitin for Aspergillus, absolute eosinophil count, chest X-ray and 
      high-resolution computed tomography of the chest. ABPA and AS were diagnosed as 
      per the recently proposed criteria. RESULTS: We enrolled 106 children [boys 72 
      (67.9%); mean age of 10.2 +/- 2.6 years] with poorly controlled asthma. The 
      prevalence of ABPA and AS were 11.3% (95% CI, 5.2-17.5%) and 61.3% (95% CI, 
      52.0-70.7%), respectively. The presence of brownish sputum was significantly more 
      in ABPA compared with non-ABPA patients (33.3 vs. 4.2%, p = 0.002). The age, 
      gender, allergic rhinitis and gastroesophageal reflux were not significantly 
      different in ABPA compared with non-ABPA patients. CONCLUSION: The prevalence of 
      ABPA and AS was 11.3 and 61.3%, respectively in children with poorly controlled 
      asthma. We could not find any risk factors for ABPA except that the presence of 
      brownish sputum was more in children with ABPA. Spirometry parameters were not 
      significantly different in ABPA compared with non-ABPA patients.
CI  - (c) The Author(s) [2019]. Published by Oxford University Press. All rights 
      reserved. For permissions, please email: journals.permissions@oup.com.
FAU - Kumari, Jyoti
AU  - Kumari J
AD  - Department of Pediatrics, All India Institute of Medical Sciences, 110029 New 
      Delhi, India.
FAU - Jat, Kana Ram
AU  - Jat KR
AD  - Department of Pediatrics, All India Institute of Medical Sciences, 110029 New 
      Delhi, India.
FAU - Lodha, Rakesh
AU  - Lodha R
AD  - Department of Pediatrics, All India Institute of Medical Sciences, 110029 New 
      Delhi, India.
FAU - Jana, Manisha
AU  - Jana M
AD  - Department of Radiodiagnosis, All India Institute of Medical Sciences, 110029 New 
      Delhi, India.
FAU - Xess, Immaculata
AU  - Xess I
AD  - Department of Microbiology, All India Institute of Medical Sciences, 110029 New 
      Delhi, India.
FAU - Kabra, Sushil K
AU  - Kabra SK
AD  - Department of Pediatrics, All India Institute of Medical Sciences, 110029 New 
      Delhi, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Trop Pediatr
JT  - Journal of tropical pediatrics
JID - 8010948
RN  - 0 (Antigens, Fungal)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Antigens, Fungal/*immunology
MH  - Aspergillosis, Allergic Bronchopulmonary/blood/diagnosis/*epidemiology
MH  - Aspergillus/*isolation & purification
MH  - Asthma/*complications/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hypersensitivity/epidemiology/*microbiology
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - India/epidemiology
MH  - Male
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - allergic bronchopulmonary aspergillosis
OT  - aspergillus sensitization
OT  - asthma
OT  - children
EDAT- 2019/10/04 06:00
MHDA- 2020/12/02 06:00
CRDT- 2019/10/04 06:00
PHST- 2019/10/04 06:00 [pubmed]
PHST- 2020/12/02 06:00 [medline]
PHST- 2019/10/04 06:00 [entrez]
AID - 5580556 [pii]
AID - 10.1093/tropej/fmz066 [doi]
PST - ppublish
SO  - J Trop Pediatr. 2020 Jun 1;66(3):275-283. doi: 10.1093/tropej/fmz066.