PMID- 31581728
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 10
DP  - 2019 Oct 2
TI  - The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of 
      Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease.
LID - 10.3390/jcm8101593 [doi]
LID - 1593
AB  - : Background: The white blood cell count to mean platelet volume ratio (WMR) is 
      increasingly gaining importance as a promising prognostic marker in 
      atherosclerotic disease, but data on lower extremity artery disease (LEAD) are 
      not yet available. The principle aim of this study was to assess the association 
      of the WMR with the occurrence of CLTI (chronic limb-threatening ischemia) as the 
      most advanced stage of disease. METHODS: This study was performed as a 
      retrospective analysis on 2121 patients with a diagnosis of LEAD. Patients were 
      admitted to the hospital for the reason of LEAD and received conservative or 
      endovascular treatment. Blood sampling, in order to obtain the required values 
      for this analysis, was implemented at admission. Statistical analysis was 
      conducted by univariate regression in a first step and, in case of significance, 
      by multivariate regression additionally. RESULTS: Multivariate regression 
      revealed an increased WMR (p < 0.001, OR (95%CI) 2.258 (1.460-3.492)), but also 
      advanced age (p < 0.001, OR (95%CI) 1.050 (1.040-1.061)), increased CRP (p < 
      0.001, OR (95%CI) 1.010 (1.007-1.014)), and diabetes (p < 0.001, OR (95%CI) 2.386 
      (1.933-2.946)) as independent predictors for CLTI. CONCLUSIONS: The WMR presents 
      an easily obtainable and cost-effective parameter to identify LEAD patients at 
      high risk for CLTI.
FAU - Guetl, Katharina
AU  - Guetl K
AD  - Division of Vascular Medicine, Department of Internal Medicine, Medical 
      University of Graz, 8036 Graz, Austria. katharina.guetl@medunigraz.at.
FAU - Raggam, Reinhard Bernd
AU  - Raggam RB
AD  - Division of Vascular Medicine, Department of Internal Medicine, Medical 
      University of Graz, 8036 Graz, Austria. reinhard.raggam@medunigraz.at.
FAU - Muster, Viktoria
AU  - Muster V
AD  - Division of Vascular Medicine, Department of Internal Medicine, Medical 
      University of Graz, 8036 Graz, Austria. viktoria.muster@medunigraz.at.
FAU - Gressenberger, Paul
AU  - Gressenberger P
AD  - Division of Vascular Medicine, Department of Internal Medicine, Medical 
      University of Graz, 8036 Graz, Austria. paul.gressenberger@medunigraz.at.
FAU - Vujic, Jovan
AU  - Vujic J
AD  - Division of Vascular Medicine, Department of Internal Medicine, Medical 
      University of Graz, 8036 Graz, Austria. jovanvuj@gmail.com.
FAU - Avian, Alexander
AU  - Avian A
AD  - Institute for Medical Informatics, Statistics and Documentation, Medical 
      University of Graz, 8036 Graz, Austria. alexander.avian@medunigraz.at.
FAU - Hafner, Franz
AU  - Hafner F
AD  - Division of Vascular Medicine, Department of Internal Medicine, Medical 
      University of Graz, 8036 Graz, Austria. franz.hafner@medunigraz.at.
FAU - Wehrschuetz, Martin
AU  - Wehrschuetz M
AD  - Department of Radiology, Medical University of Graz, 8036 Graz, Austria. 
      martin.wehrschuetz@gmail.com.
FAU - Brodmann, Marianne
AU  - Brodmann M
AD  - Division of Vascular Medicine, Department of Internal Medicine, Medical 
      University of Graz, 8036 Graz, Austria. marianne.brodmann@medunigraz.at.
FAU - Gary, Thomas
AU  - Gary T
AD  - Division of Vascular Medicine, Department of Internal Medicine, Medical 
      University of Graz, 8036 Graz, Austria. thomas.gary@medunigraz.at.
LA  - eng
PT  - Journal Article
DEP - 20191002
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6832925
OTO - NOTNLM
OT  - atherosclerosis
OT  - chronic limb-threatening ischemia
OT  - lower extremity artery disease
OT  - peripheral arterial disease
OT  - platelets
OT  - white blood cells
COIS- The authors declare no conflicts of interest.
EDAT- 2019/10/05 06:00
MHDA- 2019/10/05 06:01
PMCR- 2019/10/02
CRDT- 2019/10/05 06:00
PHST- 2019/08/19 00:00 [received]
PHST- 2019/09/19 00:00 [revised]
PHST- 2019/09/27 00:00 [accepted]
PHST- 2019/10/05 06:00 [entrez]
PHST- 2019/10/05 06:00 [pubmed]
PHST- 2019/10/05 06:01 [medline]
PHST- 2019/10/02 00:00 [pmc-release]
AID - jcm8101593 [pii]
AID - jcm-08-01593 [pii]
AID - 10.3390/jcm8101593 [doi]
PST - epublish
SO  - J Clin Med. 2019 Oct 2;8(10):1593. doi: 10.3390/jcm8101593.