PMID- 31582195
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20201201
IS  - 1545-7214 (Electronic)
IS  - 1064-7481 (Print)
IS  - 1064-7481 (Linking)
VI  - 27
IP  - 12
DP  - 2019 Dec
TI  - Negative Emotions and the Course of Depression During Psychotherapy in Suicidal 
      Older Adults With Depression and Cognitive Impairment.
PG  - 1287-1295
LID - S1064-7481(19)30491-9 [pii]
LID - 10.1016/j.jagp.2019.08.018 [doi]
AB  - OBJECTIVE: The study examines the relationship of negative emotions with: 1) 
      non-emotional symptoms (e.g., vegetative and physical symptoms) and 2) the course 
      of depression in suicidal older adults with Major Depressive Disorder (MDD) and 
      cognitive impairment treated with psychotherapy. DESIGN: The authors identified a 
      subgroup of participants (N = 26) who expressed suicidal ideation at Baseline or 
      Week 12 from a randomized controlled trial (RCT) of two psychosocial 
      interventions, Problem Adaptation Therapy (PATH) and Supportive Therapy for 
      Cognitively Impaired. The authors assessed negative emotions, non-emotional 
      symptoms of depression, depression severity, and suicidal ideation at entry, week 
      4, week 8, and week 12. PARTICIPANTS: Participants were 65 years and older and 
      had a diagnosis of unipolar depression, varying degrees of cognitive impairment 
      (up to moderate dementia) and suicidal ideation. SETTING: The study was conducted 
      in the Outpatient Department of New York Presbyterian/Weill Cornell Medicine in 
      Westchester, NY. MEASUREMENTS: Negative emotions and non-emotional items were 
      identified with the 24-item Hamilton Depression Rating Scale (Ham-D). RESULTS: 
      Among participants with suicidal ideation, the reduction in negative emotions 
      from baseline to week 4, week 4 to week 8, and week 8 to week 12 was 
      significantly associated with the reduction in non-emotional symptoms of 
      depression at weeks 4, 8, and 12 (F((1, 35)) = 6.20, p = 0.02) and with the 
      reduction in overall depression severity at weeks 4, 8, and 12 (F((1, 
      35)) = 26.63, p <0.0001) after controlling for depression severity at baseline 
      (HAM-D total score) and time trends. CONCLUSION: Our findings may guide the 
      treatment of older patients with depression and suicidal ideation to help reduce 
      depression and suicide risk.
CI  - Copyright (c) 2019 American Association for Geriatric Psychiatry. Published by 
      Elsevier Inc. All rights reserved.
FAU - Arslanoglou, Elizabeth
AU  - Arslanoglou E
AD  - Weill-Cornell Institute of Geriatric Psychiatry (EA, SB, JP, LE, DNK), Weill 
      Cornell Medicine, White Plains, NY.
FAU - Banerjee, Samprit
AU  - Banerjee S
AD  - Weill-Cornell Institute of Geriatric Psychiatry (EA, SB, JP, LE, DNK), Weill 
      Cornell Medicine, White Plains, NY.
FAU - Pantelides, Joanna
AU  - Pantelides J
AD  - Weill-Cornell Institute of Geriatric Psychiatry (EA, SB, JP, LE, DNK), Weill 
      Cornell Medicine, White Plains, NY.
FAU - Evans, Laurie
AU  - Evans L
AD  - Weill-Cornell Institute of Geriatric Psychiatry (EA, SB, JP, LE, DNK), Weill 
      Cornell Medicine, White Plains, NY.
FAU - Kiosses, Dimitris N
AU  - Kiosses DN
AD  - Weill-Cornell Institute of Geriatric Psychiatry (EA, SB, JP, LE, DNK), Weill 
      Cornell Medicine, White Plains, NY. Electronic address: dkiosses@med.cornell.edu.
LA  - eng
SI  - ClinicalTrials.gov/NCT00368940
GR  - P50 MH113838/MH/NIMH NIH HHS/United States
GR  - P30 MH085943/MH/NIMH NIH HHS/United States
GR  - R33 MH110542/MH/NIMH NIH HHS/United States
GR  - R61 MH110542/MH/NIMH NIH HHS/United States
GR  - R01 MH091045/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190826
PL  - England
TA  - Am J Geriatr Psychiatry
JT  - The American journal of geriatric psychiatry : official journal of the American 
      Association for Geriatric Psychiatry
JID - 9309609
SB  - IM
CIN - Am J Geriatr Psychiatry. 2019 Dec;27(12):1296-1298. PMID: 31564528
MH  - Aged
MH  - Aged, 80 and over
MH  - Cognitive Dysfunction/*psychology
MH  - Depression/physiopathology/psychology/*therapy
MH  - Depressive Disorder, Major/physiopathology/psychology/*therapy
MH  - Emotions
MH  - Female
MH  - Humans
MH  - Male
MH  - *Psychotherapy
MH  - Severity of Illness Index
MH  - *Suicidal Ideation
PMC - PMC6985925
MID - NIHMS1543450
OTO - NOTNLM
OT  - Suicide/self-harm
OT  - cognitive impairment
OT  - depression
OT  - elderly
OT  - negative emotions
COIS- Conflicts of Interest and Source of Funding: The authors of the article declared 
      no conflicts of interest.
EDAT- 2019/10/05 06:00
MHDA- 2020/09/01 06:00
PMCR- 2020/12/01
CRDT- 2019/10/05 06:00
PHST- 2019/06/14 00:00 [received]
PHST- 2019/08/19 00:00 [revised]
PHST- 2019/08/20 00:00 [accepted]
PHST- 2019/10/05 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
PHST- 2019/10/05 06:00 [entrez]
PHST- 2020/12/01 00:00 [pmc-release]
AID - S1064-7481(19)30491-9 [pii]
AID - 10.1016/j.jagp.2019.08.018 [doi]
PST - ppublish
SO  - Am J Geriatr Psychiatry. 2019 Dec;27(12):1287-1295. doi: 
      10.1016/j.jagp.2019.08.018. Epub 2019 Aug 26.