PMID- 31582636
OWN - NLM
STAT- MEDLINE
DCOM- 20191111
LR  - 20191111
IS  - 1347-5223 (Electronic)
IS  - 0009-2363 (Linking)
VI  - 67
IP  - 10
DP  - 2019
TI  - Chemometric Evaluation of Repeatability Using the Autocorrelation Method in 
      High-Performance Liquid Chromatography with Ultraviolet Detection.
PG  - 1160-1163
LID - 10.1248/cpb.c19-00304 [doi]
AB  - The mixed random processes of the first order autoregressive process (AR(1)) and 
      white noise have been proved to provide a good approximation of baseline noise in 
      a variety of analytical instruments, and may therefore be useful for estimating 
      precision profiles. This study aims to examine a recently proposed 
      autocorrelation method for estimating three noise parameters involved in the 
      mixed processes (two for AR(1) and one for white noise) of HPLC, which can then 
      be used to calculate the precision profile. This chemometric method was applied 
      to repeatability evaluations of estriol determination using HPLC with UV 
      detection (HPLC-UV). The relative standard deviations (RSDs) of peak area 
      measurements for 5.0 mg/L estriol were observed to be 1.42% for the 
      autocorrelation method and 1.63% for actual repeated measurements of real samples 
      (n = 6). The theoretical RSDs of the autocorrelation method fell within the 95% 
      confidence intervals of the repeated measurements. It is found that the noise 
      parameters are obtained from real chromatographic baseline via the 
      autocorrelation method. Moreover, the instrumental detection limit of estriol 
      based on ISO 11843 was obtained from the precision profile (plot of RSD of 
      measurements against concentration). This is the first paper to describe the 
      autocorrelation method is a practically useful technique for evaluating the 
      precision profile of HPLC-UV analyses without recourse to the repeated 
      measurements of real samples.
FAU - Kotani, Akira
AU  - Kotani A
AD  - School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.
FAU - Saito, Mitsuo
AU  - Saito M
AD  - School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.
AD  - Institute for Health Vigilance.
FAU - Yajima, Takehiko
AU  - Yajima T
AD  - Institute for Health Vigilance.
FAU - Hakamata, Hideki
AU  - Hakamata H
AD  - School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.
FAU - Hayashi, Yuzuru
AU  - Hayashi Y
AD  - Institute for Health Vigilance.
AD  - Institute of FUMI Theory.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Chem Pharm Bull (Tokyo)
JT  - Chemical & pharmaceutical bulletin
JID - 0377775
RN  - 0 (Flavonoids)
RN  - 347Q89U4M5 (baicalin)
RN  - FB33469R8E (Estriol)
SB  - IM
MH  - Chromatography, High Pressure Liquid
MH  - Estriol/*analysis
MH  - Flavonoids/*analysis
MH  - Spectrophotometry, Ultraviolet
OTO - NOTNLM
OT  - FUMI theory
OT  - autocorrelation method
OT  - baseline noise
OT  - repeatability
OT  - stochastic process
EDAT- 2019/10/05 06:00
MHDA- 2019/11/12 06:00
CRDT- 2019/10/05 06:00
PHST- 2019/10/05 06:00 [entrez]
PHST- 2019/10/05 06:00 [pubmed]
PHST- 2019/11/12 06:00 [medline]
AID - 10.1248/cpb.c19-00304 [doi]
PST - ppublish
SO  - Chem Pharm Bull (Tokyo). 2019;67(10):1160-1163. doi: 10.1248/cpb.c19-00304.