PMID- 31583168
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220520
IS  - 2229-5097 (Print)
IS  - 2152-7806 (Electronic)
IS  - 2152-7806 (Linking)
VI  - 10
DP  - 2019
TI  - Acute myeloid leukemia with central nervous system extension and subdural seeding 
      of vancomycin-resistant Enterococcus faecium after bilateral subdural hematomas 
      treated with subdural daptomycin administration.
PG  - 171
LID - 10.25259/SNI_225_2019 [doi]
LID - 171
AB  - BACKGROUND: We present a rare case of comorbid relapsed acute myeloid leukemia 
      (AML) with the involvement of the central nervous system (CNS) and subdural 
      seeding of vancomycin-resistant Enterococcus faecium (VRE). The safety profile, 
      treatment approach with pharmacokinetic considerations, and evaluation of success 
      for bilateral subdural administration of daptomycin after subdural hematoma (SDH) 
      are assessed. CASE DESCRIPTION: A 45-year-old male with a history of AML who 
      underwent chemotherapy (induction with 7 + 3) was admitted to oncology with 
      relapsed AML confirmed by bone marrow biopsy, complicated by neutropenic fever 
      and VRE bacteremia. After acute neurological changes with image confirmation of 
      mixed- density bilateral SDHs secondary to thrombocytopenia, the patient was 
      admitted to the neurosurgery unit and underwent bilateral burr hole craniotomies 
      for subdural evacuation with the placement of the left and right subdural drains. 
      Culture of the subdural specimen confirmed VRE seeding of the subdural space. The 
      patient received the first dose of daptomycin into the bilateral subdural spaces 
      2 days after evacuation and was noted to have acute improvement on neurological 
      examination, followed by a second administration to the left subdural space 5 
      days after evacuation with bilateral drains pulled thereafter. CONCLUSION: In 
      this patient, the complication of relapsed AML may have contributed to the rare 
      extension of VRE into the CNS space. Screening for patients at risk of AML with 
      CNS involvement and addressing coagulopathy and risk of infection may help 
      mitigate morbidity. Bilateral administration of subdural daptomycin bolus into 
      the subdural space was tolerated and possibly contributed to the patient's 
      neurological improvement during an extended hospital course.
CI  - Copyright: (c) 2019 Surgical Neurology International.
FAU - Dietz, Nicholas
AU  - Dietz N
AD  - Department of Neurosurgery, School of Medicine, Georgetown University, 
      Washington, DC, USA.
FAU - Barra, Megan
AU  - Barra M
AD  - Department of Pharmacy, Massachusetts General Hospital, Boston, MA, USA.
FAU - Zhang, Mingjuan
AU  - Zhang M
AD  - Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
FAU - Zacharaiah, Marcus
AU  - Zacharaiah M
AD  - Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
FAU - Coumans, Jean-Valery
AU  - Coumans JV
AD  - Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
LA  - eng
PT  - Case Reports
DEP - 20190910
PL  - United States
TA  - Surg Neurol Int
JT  - Surgical neurology international
JID - 101535836
EIN - Surg Neurol Int. 2020 Dec 17;11:422. PMID: 35592010
PMC - PMC6763666
OTO - NOTNLM
OT  - Acute myeloid leukemia
OT  - Acute myeloid leukemia with central nervous system involvement
OT  - Daptomycin
OT  - Subdural administration
OT  - Subdural hematoma
COIS- There are no conflicts of interest.
EDAT- 2019/10/05 06:00
MHDA- 2019/10/05 06:01
PMCR- 2019/09/10
CRDT- 2019/10/05 06:00
PHST- 2019/07/19 00:00 [received]
PHST- 2019/08/20 00:00 [accepted]
PHST- 2019/10/05 06:00 [entrez]
PHST- 2019/10/05 06:00 [pubmed]
PHST- 2019/10/05 06:01 [medline]
PHST- 2019/09/10 00:00 [pmc-release]
AID - SNI-10-171 [pii]
AID - 10.25259/SNI_225_2019 [doi]
PST - epublish
SO  - Surg Neurol Int. 2019 Sep 10;10:171. doi: 10.25259/SNI_225_2019. eCollection 
      2019.