PMID- 31584380
OWN - NLM
STAT- MEDLINE
DCOM- 20210401
LR  - 20210401
IS  - 1875-6638 (Electronic)
IS  - 1573-4064 (Linking)
VI  - 16
IP  - 5
DP  - 2020
TI  - The Assessment of Interleukin-18 on the Risk of Coronary Heart Disease.
PG  - 626-634
LID - 10.2174/1573406415666191004115128 [doi]
AB  - BACKGROUND: Observational studies support the inflammation hypothesis in coronary 
      heart disease (CHD). As a pleiotropic proinflammatory cytokine, Interleukin-18 
      (IL-18), has also been found to be associated with the risk of CHD. However, to 
      our knowledge, the method of Mendelian Randomization has not been used to explore 
      the causal effect of IL-18 on CHD. OBJECTIVE: To assess the causal effect of 
      IL-18 on the risk of CHD. METHODS AND RESULTS: Genetic variant instruments for 
      IL-18 were obtained from information of the CHS and InCHIANTI cohort, and 
      consisted of the per-allele difference in mean IL-18 for 16 independent variants 
      that reached genome-wide significance. The per-allele difference in log-odds of 
      CHD for each of these variants was estimated from CARDIoGRAMplusC4D, a two-stage 
      meta -analysis. Two-sample Mendelian Randomization (MR) was then performed. 
      Various MR analyses were used, including weighted inverse-variance, MR-Egger 
      regression, robust regression, and penalized regression. The OR of elevated IL-18 
      associated with CHD was only 0.005 (95%CI -0.105~0.095; P-value=0.927). Similar 
      results were obtained with the use of MR-Egger regression, suggesting that 
      directional pleiotropy was unlikely biasing these results (intercept -0.050, 
      P-value=0.220). Moreover, results from the robust regression and penalized 
      regression analyses also revealed essentially similar findings. CONCLUSION: Our 
      findings indicate that, by itself, IL-18 is unlikely to represent even a modest 
      causal factor for CHD risk.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Sun, Weiju
AU  - Sun W
AD  - Cardiovascular Department, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, China.
FAU - Han, Ying
AU  - Han Y
AD  - Cardiovascular Department, the Fourth Affiliated Hospital of Harbin Medical 
      University, Harbin, China.
FAU - Yang, Shuo
AU  - Yang S
AD  - College of Bioinformatics Science and Technology, Harbin Medical University, 
      Harbin, China.
FAU - Zhuang, He
AU  - Zhuang H
AD  - College of Bioinformatics Science and Technology, Harbin Medical University, 
      Harbin, China.
FAU - Zhang, Jingwen
AU  - Zhang J
AD  - Department of Physiology and Biology, University of Mississippi Medical Center, 
      United States.
FAU - Cheng, Liang
AU  - Cheng L
AD  - College of Bioinformatics Science and Technology, Harbin Medical University, 
      Harbin, China.
FAU - Fu, Lu
AU  - Fu L
AD  - Cardiovascular Department, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - Netherlands
TA  - Med Chem
JT  - Medicinal chemistry (Shariqah (United Arab Emirates))
JID - 101240303
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Aged
MH  - Coronary Disease/*genetics
MH  - Female
MH  - Genetic Variation/genetics
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - *Mendelian Randomization Analysis
MH  - Risk Factors
OTO - NOTNLM
OT  - Interleukin-18
OT  - Mendelian Randomisation
OT  - casual effect
OT  - coronary heart disease
OT  - cytokines
OT  - risk
EDAT- 2019/10/05 06:00
MHDA- 2021/04/02 06:00
CRDT- 2019/10/05 06:00
PHST- 2019/04/09 00:00 [received]
PHST- 2019/05/13 00:00 [revised]
PHST- 2019/08/23 00:00 [accepted]
PHST- 2019/10/05 06:00 [pubmed]
PHST- 2021/04/02 06:00 [medline]
PHST- 2019/10/05 06:00 [entrez]
AID - MC-EPUB-101187 [pii]
AID - 10.2174/1573406415666191004115128 [doi]
PST - ppublish
SO  - Med Chem. 2020;16(5):626-634. doi: 10.2174/1573406415666191004115128.