PMID- 31586136
OWN - NLM
STAT- MEDLINE
DCOM- 20201111
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Oct 4
TI  - Sex differences in risk factors for stroke in patients with hypertension and 
      hyperhomocysteinemia.
PG  - 14313
LID - 10.1038/s41598-019-50856-z [doi]
LID - 14313
AB  - Data on the sex-specific differences in risk of stroke among patients with H-type 
      hypertension are limited. We aimed to analyze interactions between sex and other 
      risk factors on stroke, including the sex-methylenetetrahydrofolate reductase 
      (MTHFR) interaction. A retrospective analysis of baseline data from 2040 patients 
      with hypertension and hyperhomocysteinemia (HHcy) included demographic 
      characteristics, biomarkers, history of chronic diseases and lifestyle factors. 
      Polymerase chain reaction-restriction fragment length polymorphism method was 
      used to investigate the C677T polymorphism of MTHFR gene. We examined independent 
      effects and interactions between sex and stratified factors on the risk of stroke 
      by logistic regression model. A total of 1412 patients suffered stroke, and the 
      prevalence of stroke was 70.65% in men and 66.53% in women. Both men and women 
      had independent risk factors for stroke, including diabetes mellitus, atrial 
      fibrillation, smoking, increased level of systolic blood pressure (SBP) and 
      plasma total homocysteine (tHcy), as well as the decreased level of high-density 
      lipoprotein cholesterol. Diastolic blood pressure (DBP) -specific risk of stroke 
      was unique to men. Interactions between sex and other risk factors on stroke risk 
      were statistically significant: age, fasting plasma glucose (FPG), SBP, DBP, 
      triglycerides (TG) and tHcy. Furthermore, tHcy interacted with age, SBP and DBP 
      in men, and age, SBP, DBP, FPG, and TG in women to modulate the risk of stroke. 
      Although TT genotype did not have an independent effect on stroke, it could 
      interact with sex and FPG, TG and SBP to increase stroke. In conclusion, 
      sex-specific differences are useful to stratify the risk of stroke and assist 
      clinicians in the decision to select a reasonable therapeutic option for 
      high-risk patients.
FAU - Pang, Hui
AU  - Pang H
AD  - Department of Cardiology, Xuzhou Central Hospital, Xuzhou Clinical School of 
      Xuzhou Medical University, Xuzhou, Jiangsu, China. phui81@126.com.
FAU - Fu, Qiang
AU  - Fu Q
AD  - Department of Cardiology, Xuzhou Central Hospital, Xuzhou Clinical School of 
      Xuzhou Medical University, Xuzhou, Jiangsu, China.
FAU - Cao, Qiumei
AU  - Cao Q
AD  - Department of Cardiology, Xuzhou Central Hospital, Xuzhou Clinical School of 
      Xuzhou Medical University, Xuzhou, Jiangsu, China.
FAU - Hao, Lin
AU  - Hao L
AD  - Department of Urinary Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu, China.
FAU - Zong, Zhenkun
AU  - Zong Z
AD  - Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, 
      Xuzhou, Jiangsu, China. zongzhenkun2009@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191004
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Aged
MH  - China/epidemiology
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*epidemiology
MH  - Hypertension/*epidemiology
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Sex Factors
MH  - Stroke/*epidemiology
PMC - PMC6778198
COIS- The authors declare no competing interests.
EDAT- 2019/10/06 06:00
MHDA- 2020/11/12 06:00
PMCR- 2019/10/04
CRDT- 2019/10/06 06:00
PHST- 2019/03/29 00:00 [received]
PHST- 2019/09/20 00:00 [accepted]
PHST- 2019/10/06 06:00 [entrez]
PHST- 2019/10/06 06:00 [pubmed]
PHST- 2020/11/12 06:00 [medline]
PHST- 2019/10/04 00:00 [pmc-release]
AID - 10.1038/s41598-019-50856-z [pii]
AID - 50856 [pii]
AID - 10.1038/s41598-019-50856-z [doi]
PST - epublish
SO  - Sci Rep. 2019 Oct 4;9(1):14313. doi: 10.1038/s41598-019-50856-z.