PMID- 31586312
OWN - NLM
STAT- MEDLINE
DCOM- 20200504
LR  - 20200505
IS  - 2038-3312 (Electronic)
IS  - 2038-131X (Linking)
VI  - 71
IP  - 4
DP  - 2019 Dec
TI  - BRAF(V600E) mutation: a potential predictor of more than a Sistrunk's procedure 
      in patients with thyroglossal duct cyst carcinoma and a normal thyroid gland.
PG  - 701-704
LID - 10.1007/s13304-019-00684-7 [doi]
AB  - To assess the utility of mutational markers in determining the most appropriate 
      initial surgery for patients with thyroglossal duct cyst carcinoma (TGDCCa) and a 
      normal thyroid gland. Our sample comprised 15 patients with a diagnosis of TGDCCa 
      and a thyroid gland histologically negative for any malignant involvement, who 
      underwent surgery between the years 1994 and 2017. Clinical records were reviewed 
      and tissue specimens were genetically tested for the presence of the most 
      commonly encountered mutational markers in differentiated thyroid cancer: BRAF, 
      N-RAS, and H-RAS. The primary outcome of interest was the correlation between 
      mutational marker positivity and the T-stage of the primary tumor and its 
      potential implication on therapeutic decision making. All 15 cases were papillary 
      carcinomas with a mean tumor size of 17 mm (2-40 mm). According to the 7th 
      edition of the American Joint Committee on Cancer TNM staging system, these 
      represented: T(1) (n = 3), T(2) (n = 1), and T(3) (n = 11). Cancerous invasion of 
      the pericystic soft tissue and/or hyoid bone was considered T3. BRAF(V600E) was 
      the only mutational marker identified (7 in 15 cases). All BRAF(V600E)-positive 
      lesions were T(3), necessitating radioactive iodine ablation (RIA) therapy, 
      therefore, total thyroidectomy. The correlation between BRAF(V600E) positivity 
      and extracystic cancerous extension was statistically significant [1.0 (7/7) vs. 
      0.5 (4/8); p value = 0.0035]. BRAF(V600E) positivity seems to be predictive of 
      locally advanced disease mandating RIA therapy. Therefore, it could serve as a 
      preoperative tool that predicts the need for total thyroidectomy, in addition to 
      Sistrunk's procedure.
FAU - Bakkar, Sohail
AU  - Bakkar S
AUID- ORCID: 0000-0001-8479-5901
AD  - Department of Surgery, Faculty of Medicine, The Hashemite University, Zarqa, 
      13133, Jordan. sohail.bakkar@gmail.com.
AD  - Department of Surgical Pathology, the University of Pisa, 56124, Pisa, Italy. 
      sohail.bakkar@gmail.com.
FAU - Macerola, Elisabetta
AU  - Macerola E
AD  - Department of Surgical Pathology, the University of Pisa, 56124, Pisa, Italy.
FAU - Aljarrah, Qusai
AU  - Aljarrah Q
AD  - Department of Surgery, Faculty of Medicine, Jordan University of Science and 
      Technology, Irbid, 22110, Jordan.
FAU - Proietti, Agnese
AU  - Proietti A
AD  - Department of Surgical Pathology, the University of Pisa, 56124, Pisa, Italy.
FAU - Materazzi, Gabriele
AU  - Materazzi G
AD  - Department of Surgical Pathology, the University of Pisa, 56124, Pisa, Italy.
FAU - Basolo, Fulvio
AU  - Basolo F
AD  - Department of Surgical Pathology, the University of Pisa, 56124, Pisa, Italy.
FAU - Miccoli, Paolo
AU  - Miccoli P
AD  - Department of Surgical Pathology, the University of Pisa, 56124, Pisa, Italy.
LA  - eng
PT  - Journal Article
DEP - 20191004
PL  - Italy
TA  - Updates Surg
JT  - Updates in surgery
JID - 101539818
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.11.1 (BRAF protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins B-raf)
SB  - IM
MH  - Biomarkers, Tumor/analysis/*genetics
MH  - Clinical Decision-Making
MH  - Connective Tissue/pathology
MH  - Humans
MH  - Hyoid Bone/pathology
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Proto-Oncogene Proteins B-raf/analysis/*genetics
MH  - Thyroglossal Cyst/*genetics/pathology/surgery
MH  - Thyroid Cancer, Papillary/*genetics/pathology/surgery
MH  - Thyroid Gland/anatomy & histology
MH  - Thyroid Neoplasms/*genetics/pathology/surgery
MH  - Thyroidectomy
OTO - NOTNLM
OT  - BRAF V600E
OT  - Molecular markers
OT  - Papillary thyroid carcinoma
OT  - Sistrunk's procedure
OT  - Thyroglossal cyst carcinoma
OT  - Total thyroidectomy
EDAT- 2019/10/06 06:00
MHDA- 2020/05/06 06:00
CRDT- 2019/10/06 06:00
PHST- 2019/02/20 00:00 [received]
PHST- 2019/09/30 00:00 [accepted]
PHST- 2019/10/06 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2019/10/06 06:00 [entrez]
AID - 10.1007/s13304-019-00684-7 [pii]
AID - 10.1007/s13304-019-00684-7 [doi]
PST - ppublish
SO  - Updates Surg. 2019 Dec;71(4):701-704. doi: 10.1007/s13304-019-00684-7. Epub 2019 
      Oct 4.