PMID- 31586563 OWN - NLM STAT- MEDLINE DCOM- 20210428 LR - 20240328 IS - 1872-7549 (Electronic) IS - 0166-4328 (Print) IS - 0166-4328 (Linking) VI - 378 DP - 2020 Jan 27 TI - NS-Pten adult knockout mice display both quantitative and qualitative changes in urine-induced ultrasonic vocalizations. PG - 112189 LID - S0166-4328(19)30994-5 [pii] LID - 10.1016/j.bbr.2019.112189 [doi] AB - The NS-Pten knockout (KO) mouse exhibits hyperactivity of the mammalian target of rapamycin (mTOR) and is a model of autism spectrum disorder (ASD). ASD presents with marked deficits in communication which can be elucidated by investigating their counterpart in mice, ultrasonic vocalizations (USVs). While USVs have been found to be altered in NS-Pten KO pups, no study has assessed whether this communication deficit persists into adulthood. In the present study, we investigate female urine-induced USVs, scent marking behavior, and open field activity in NS-Pten KO and wildtype (WT) adult male mice. Results showed that there was no difference in the quantity of vocalizations produced between groups, however, there were extensive alterations in the spectral properties of USVs. KO mice emitted vocalizations of a lower peak frequency, shorter duration, and higher peak amplitude compared to WT mice. KO animals also emitted a significantly different distribution of call-types relative to controls, displaying increased complex and short calls, but fewer upward, chevron, frequency steps, and composite calls. No significant differences between groups were observed for scent marking behavior and there was no difference between groups in the amount of time spent near the female urine. Overall, this study demonstrated that mTOR hyperactivity contributes to communication deficits in adult mice. CI - Copyright (c) 2019. Published by Elsevier B.V. FAU - Binder, Matthew S AU - Binder MS AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX, 76798, USA. FAU - Jones, Dalton G AU - Jones DG AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX, 76798, USA. FAU - Hodges, Samantha L AU - Hodges SL AD - Institute of Biomedical Studies, Baylor University, Waco TX 76798, USA. FAU - Lugo, Joaquin N AU - Lugo JN AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX, 76798, USA; Institute of Biomedical Studies, Baylor University, Waco TX 76798, USA; Department of Biology, Baylor University, Waco, TX, 76798, USA. Electronic address: joaquin_lugo@baylor.edu. LA - eng GR - R15 NS088776/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20191003 PL - Netherlands TA - Behav Brain Res JT - Behavioural brain research JID - 8004872 RN - EC 2.7.1.1 (mTOR protein, mouse) RN - EC 2.7.11.1 (TOR Serine-Threonine Kinases) RN - EC 3.1.3.67 (PTEN Phosphohydrolase) RN - EC 3.1.3.67 (Pten protein, mouse) SB - IM MH - Animals MH - Autism Spectrum Disorder/*metabolism/*physiopathology MH - Disease Models, Animal MH - Male MH - Mice MH - Mice, Knockout MH - PTEN Phosphohydrolase/*deficiency MH - *Social Behavior MH - TOR Serine-Threonine Kinases/*metabolism MH - Ultrasonics MH - Vocalization, Animal/*physiology PMC - PMC7000110 MID - NIHMS1545232 OTO - NOTNLM OT - Call-types OT - Communication deficits OT - Scent marking OT - UV OT - mTOR EDAT- 2019/10/07 06:00 MHDA- 2021/04/29 06:00 PMCR- 2021/01/27 CRDT- 2019/10/07 06:00 PHST- 2019/06/27 00:00 [received] PHST- 2019/07/31 00:00 [revised] PHST- 2019/08/28 00:00 [accepted] PHST- 2019/10/07 06:00 [pubmed] PHST- 2021/04/29 06:00 [medline] PHST- 2019/10/07 06:00 [entrez] PHST- 2021/01/27 00:00 [pmc-release] AID - S0166-4328(19)30994-5 [pii] AID - 10.1016/j.bbr.2019.112189 [doi] PST - ppublish SO - Behav Brain Res. 2020 Jan 27;378:112189. doi: 10.1016/j.bbr.2019.112189. Epub 2019 Oct 3.