PMID- 31586839
OWN - NLM
STAT- MEDLINE
DCOM- 20200424
LR  - 20200424
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 281
DP  - 2019 Nov
TI  - Neurocognition in young offspring of individuals with bipolar disorder: The role 
      of co-existing familial and clinical high-risk for bipolar disorder.
PG  - 112565
LID - S0165-1781(19)30898-4 [pii]
LID - 10.1016/j.psychres.2019.112565 [doi]
AB  - Bipolar disorder (BD) is associated with cognitive dysfunction which has also 
      been reported in offspring of individuals with BD (BDoff). However, it remains 
      unclear whether cognitive underperformance in BDoff is associated with the 
      presence of history of subclinical syndromes associated with risk for BD. To 
      address this knowledge gap we assessed executive function, visual and verbal 
      memory, working memory, processing speed and verbal fluency in 21 offspring with 
      clinical high risk (CHR; BDoff+CHR), 54 offspring without CHR (BDoff-non-CHR), 
      and 50 healthy individuals without familial risk of BD. BDoff underperformed 
      compared to controls in most cognitive tasks. There was no significant 
      neurocognitive difference between BDoff+CHR and BDoff-non-CHR except in the 
      fluency/central executive domain (Cohen's d = 0.60, p = 0.03). Our results 
      suggest that cognitive dysfunction in multiple domains is associated with 
      familial predisposition to BD regardless of CHR status. On the other hand, 
      abnormalities in central executive processes might be more pronounced in 
      BDoff+CHR than BDoff-non-CHR. Further longitudinal studies investigating 
      cognitive trajectory of BDoff and its interaction with the emergence of 
      subclinical syndromes are needed to fully characterize the relationship between 
      cognition and mood dysregulation in BD.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Can, Gunes
AU  - Can G
AD  - Department of Psychiatry, Mardin State Hospital, Mardin, Turkey.
FAU - Bora, Emre
AU  - Bora E
AD  - Dokuz Eylul University, Faculty of Medicine, Department of Psychiatry, Izmir, 
      Turkey; Dokuz Eylul University, Institute of Neuroscience, Izmir, Turkey; 
      Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of 
      Melbourne. Electronic address: emre.bora@deu.edu.tr.
FAU - Ildiz, Aysegul
AU  - Ildiz A
AD  - Dokuz Eylul University, Institute of Neuroscience, Izmir, Turkey.
FAU - Ulas, Gozde
AU  - Ulas G
AD  - Department of Child and Adolescent Psychiatry, Cankiri State Hospital, Cankiri, 
      Turkey.
FAU - Ongun, Ceren Hidiroglu
AU  - Ongun CH
AD  - Dokuz Eylul University Faculty of Arts, Department of Psychology, Izmir, Turkey.
FAU - Sprooten, Emma
AU  - Sprooten E
AD  - Radboud University, Donders Institute for Brain, Cognition and Behaviour, 
      Nijmegen, the Netherlands.
FAU - Frangou, Sophia
AU  - Frangou S
AD  - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, 
      United States.
FAU - Inal, Neslihan Emiroglu
AU  - Inal NE
AD  - Dokuz Eylul University Faculty of Medicine, Department of Child and Adolescent 
      Psychiatry, Izmir, Turkey.
FAU - Ozerdem, Aysegul
AU  - Ozerdem A
AD  - Dokuz Eylul University, Faculty of Medicine, Department of Psychiatry, Izmir, 
      Turkey; Dokuz Eylul University, Institute of Neuroscience, Izmir, Turkey; 
      Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United 
      States.
LA  - eng
PT  - Journal Article
DEP - 20190922
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bipolar Disorder/*psychology
MH  - Child of Impaired Parents/*psychology
MH  - Cognition/physiology
MH  - Cognitive Dysfunction/*psychology
MH  - Executive Function/physiology
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Memory, Short-Term
MH  - Neuropsychological Tests
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Cognition
OT  - Offspring
OT  - Relatives
EDAT- 2019/10/07 06:00
MHDA- 2020/04/25 06:00
CRDT- 2019/10/07 06:00
PHST- 2019/05/19 00:00 [received]
PHST- 2019/09/10 00:00 [revised]
PHST- 2019/09/12 00:00 [accepted]
PHST- 2019/10/07 06:00 [pubmed]
PHST- 2020/04/25 06:00 [medline]
PHST- 2019/10/07 06:00 [entrez]
AID - S0165-1781(19)30898-4 [pii]
AID - 10.1016/j.psychres.2019.112565 [doi]
PST - ppublish
SO  - Psychiatry Res. 2019 Nov;281:112565. doi: 10.1016/j.psychres.2019.112565. Epub 
      2019 Sep 22.