PMID- 31587051
OWN - NLM
STAT- MEDLINE
DCOM- 20200924
LR  - 20221207
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 105
IP  - 2
DP  - 2020 Feb 1
TI  - Bone Histomorphometry in Young Patients With Type 2 Diabetes is Affected by 
      Disease Control and Chronic Complications.
LID - dgz070 [pii]
LID - 10.1210/clinem/dgz070 [doi]
AB  - CONTEXT: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of 
      fractures. No study has evaluated the correlation of bone histomorphometry (BH) 
      parameters with glycemic control and presence of chronic complications (CCs) in 
      premenopausal women with T2DM. OBJECTIVES: To evaluate BH and correlate them with 
      the degree of glycemic control and presence of CCs. DESIGN, SETTINGS, AND 
      PATIENTS: This was a cross-sectional study conducted at a tertiary medical 
      center. Twenty-six premenopausal women with T2DM were divided into groups with 
      glycated hemoglobin HbA1c < 7% (good control, GC; n = 10) and HbA1c > 7% (poor 
      control, PC; n = 16), and further subdivided into groups with (n = 9) and without 
      (n = 17) CCs. BH parameters (bone volume [bone volume per total volume, BV/TV], 
      trabecular thickness [Tb.Th], trabecular number [Tb.N], trabecular separation 
      [Tb.Sp], osteoid thickness [O.Th], osteoid surface [osteoid surface per bone 
      surface, OS/BS]), mineralizing surface [MS/BS], bone formation rate [BFR]), 
      mineral apposition rate [MAR]) as well as serum pentosidine (PEN) and 
      insulin-like growth factor (IGF)-1 were measured. The BH data were compared among 
      the groups and with a BH control group (control group, CG, n = 15) matched by 
      age, sex, and race. RESULTS: BV/TV was increased in GC (P < .001) and PC (P = 
      .05) groups and O.th (P = .03) was smaller in the PC group than in the CG. A 
      comparison of the groups with and without CCs with the CG showed in the group 
      with CCs, O.Th was smaller(P = .01) and BV/TV similar to the CG (P = .11). HbA1c 
      correlated negatively with O.Th (P = .02) and OS/BS (P = .01). There was no 
      correlation of BH to PEN and IGF-1. CONCLUSION: BH in premenopausal patients with 
      T2DM is affected by disease control and chronic complications.
CI  - (c) Endocrine Society 2019. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Andrade, Vicente F C
AU  - Andrade VFC
AD  - Endocrine Division (SEMPR), Department of Internal Medicine, Federal University 
      of Parana, Curitiba, Brazil.
FAU - Chula, Domingos C
AU  - Chula DC
AD  - Nephrology Unit, Clinics Hospital of Federal University of Parana, Curitiba, 
      Brazil.
FAU - Sabbag, Fabio P
AU  - Sabbag FP
AD  - Ophthalmologist, retinal and vitreo specialist at the Clinic Center of Vision, 
      Medical School of Ribeirao Preto, Sao Paulo University, Curitiba, Sao Paulo, 
      Brazil.
FAU - Cavalheiro, Daniel D da S
AU  - Cavalheiro DDDS
AD  - Radiology Clinic, Advanced Diagnostic Imaging (DAPI), Curitiba, Brazil.
FAU - Bavia, Lorena
AU  - Bavia L
AD  - Laboratory of Molecular Immunopathology, Department of Medical Pathology, Clinics 
      Hospital of Federal do Parana University, Brazil.
FAU - Ambrosio, Altair Rogerio
AU  - Ambrosio AR
AD  - Laboratory of Molecular Immunopathology, Department of Medical Pathology, Clinics 
      Hospital of Federal do Parana University, Brazil.
FAU - da Costa, Cleber Rafael V
AU  - da Costa CRV
AD  - Laboratory PRO, Section of bone histomorphometry, Fundacao Pro-Renal, Curitiba, 
      Brazil.
FAU - Dos Reis, Luciene M
AU  - Dos Reis LM
AD  - LIM 16 - Laboratory of Renal Physiopathology, Clinics Hospital (HCFMUSP), School 
      of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
FAU - Borba, Victoria Z C
AU  - Borba VZC
AD  - Endocrine Division (SEMPR), Department of Internal Medicine, Federal University 
      of Parana, Curitiba, Brazil.
FAU - Moreira, Carolina Aguiar
AU  - Moreira CA
AD  - Endocrine Division (SEMPR), Department of Internal Medicine, Federal University 
      of Parana, Curitiba, Brazil.
AD  - Laboratory PRO, Section of bone histomorphometry, Fundacao Pro-Renal, Curitiba, 
      Brazil.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (IGF1 protein, human)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 94ZLA3W45F (Arginine)
RN  - BJ4I2X2CQJ (pentosidine)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Adult
MH  - Arginine/analogs & derivatives/blood
MH  - Blood Glucose/analysis
MH  - *Bone Development
MH  - Bone Diseases/*etiology
MH  - Cancellous Bone/physiopathology
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/complications/*physiopathology
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Insulin-Like Growth Factor I/analysis
MH  - Lysine/analogs & derivatives/blood
MH  - Male
EDAT- 2019/10/07 06:00
MHDA- 2020/09/25 06:00
CRDT- 2019/10/07 06:00
PHST- 2019/05/21 00:00 [received]
PHST- 2019/10/03 00:00 [accepted]
PHST- 2019/10/07 06:00 [pubmed]
PHST- 2020/09/25 06:00 [medline]
PHST- 2019/10/07 06:00 [entrez]
AID - 5582037 [pii]
AID - 10.1210/clinem/dgz070 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2020 Feb 1;105(2):dgz070. doi: 10.1210/clinem/dgz070.