PMID- 31587349
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20200413
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 46
IP  - 12
DP  - 2019 Dec
TI  - Prevalence of atopy and staphylococcal superantigen-specific immunoglobulin E 
      (IgE) antibodies and total serum IgE in primary cutaneous T- and B-cell lymphoma.
PG  - 1170-1178
LID - 10.1111/1346-8138.15059 [doi]
AB  - The prevalence of atopy was investigated in 20 patients with Sezary syndrome 
      (SS), 20 patients with plaque phase mycosis fungoides (MF), 9 patients with 
      primary cutaneous marginal zone lymphoma (pcMZL) and 8 patients with primary 
      cutaneous follicle center lymphoma (pcFCL) with the Phadiatop multi-allergen 
      test. The relationship among serologic atopy, IgE reactivity against 
      Staphyloccocal enterotoxin superantigens, and serum total IgE (IgE-t) levels and 
      their prognostic implications in SS was investigated. Phadiatop test was positive 
      in 45%, 15%, 33% and 0% of samples of SS, MF, pcMZL and pcFCL, respectively. 
      IgE-t levels were also increased in SS, pcMZL and marginally MF. No correlation 
      was found with patients' history of atopic disorders. Staphylococcal 
      superantigen-specific IgE >/= 0.35 kUa/L, most often against toxic shock syndrome 
      toxin-1, was detected in 40% of Sezary samples followed by MF (20%). In the 
      absence of serologic atopy (negative Phadiatop test), IgE-t levels for patients 
      with SS and MF were not significantly higher than controls whereas the levels for 
      pcMZL remained high. Furthermore, even with a negative Phadiatop test, IgE-t 
      values were higher in sera of patients with SSAg-IgE >/= 0.35 kUa/L vis-a-vis < 
      0.35 kUa/L across all diagnostic categories including controls albeit the 
      difference was statistically significant only for SS. The presence of specific 
      IgE antibodies >/= 0.35 kUa/L, IgE-t > 122 kU/L or eosinophils > 500/microL had no 
      impact on survival of patients with SS. These results indicate that a pathogenic 
      link may exist between an atopic diathesis and development of SS and possibly 
      pcMZL.
CI  - (c) 2019 Japanese Dermatological Association.
FAU - Vonderheid, Eric C
AU  - Vonderheid EC
AUID- ORCID: 0000-0002-6100-3403
AD  - Sydney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, 
      Maryland, USA.
FAU - Hamilton, Robert G
AU  - Hamilton RG
AD  - Johns Hopkins University School of Medicine, Asthma and Allergy Center, 
      Baltimore, Maryland, USA.
FAU - Kadin, Marshall E
AU  - Kadin ME
AD  - Department of Dermatology, Boston University and Roger Williams Medical Center, 
      Providence, Rhode Island, USA.
LA  - eng
GR  - Drs Martin and Dorothy Spatz Foundation/
PT  - Journal Article
DEP - 20191006
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Baltimore/epidemiology
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Mycosis Fungoides/*immunology
MH  - *Registries
MH  - Sezary Syndrome/*immunology/mortality
OTO - NOTNLM
OT  - Sezary syndrome
OT  - atopy
OT  - immunoglobulin E
OT  - lymphoma
OT  - superantigens
EDAT- 2019/10/07 06:00
MHDA- 2020/04/14 06:00
CRDT- 2019/10/07 06:00
PHST- 2019/07/08 00:00 [received]
PHST- 2019/07/26 00:00 [accepted]
PHST- 2019/10/07 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2019/10/07 06:00 [entrez]
AID - 10.1111/1346-8138.15059 [doi]
PST - ppublish
SO  - J Dermatol. 2019 Dec;46(12):1170-1178. doi: 10.1111/1346-8138.15059. Epub 2019 
      Oct 6.