PMID- 31587447
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20200518
IS  - 1529-8019 (Electronic)
IS  - 1396-0296 (Linking)
VI  - 32
IP  - 6
DP  - 2019 Nov
TI  - Depression, isotretinoin, and folic acid: A practical review.
PG  - e13104
LID - 10.1111/dth.13104 [doi]
AB  - Isotretinoin (ISO) is a first-generation retinoid discovered in 1952 and approved 
      by the FDA for the treatment of nodulocystic acne in 1982. The anti-inflammatory 
      properties of ISO have found its use in disorders other than acne. ISO can create 
      psychiatric problems, including depression and suicidal ideation. These 
      neuropsychiatric problems are very similar to disorders secondary to 
      hyperhomocysteinemia (HHcy), vitamin B12, and folic acid (vitamin B9) 
      deficiencies. Given that previous literature suggested folate supplementation 
      improved the efficacy of traditional antidepressant medications, clinicians may 
      wish to consider folate supplementation for patients with depression or possible 
      depressive symptoms, such as acne patients with genetic susceptibility. 
      Brain-derived neurotrophic factor may be a cytokine-specific screening biomarker 
      in immune-based antidepressive therapy.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Abdelmaksoud, Ayman
AU  - Abdelmaksoud A
AUID- ORCID: 0000-0003-4848-959X
AD  - Mansoura Dermatology, Venerology and Leprology Hospital, Mansoura, Egypt.
FAU - Vojvodic, Aleksandra
AU  - Vojvodic A
AUID- ORCID: 0000-0002-2057-3776
AD  - Department of Dermatology and Venereology, Military Medical Academy of Belgrade, 
      Serbia.
FAU - Ayhan, Erhan
AU  - Ayhan E
AUID- ORCID: 0000-0003-1416-2636
AD  - Department of Dermatology, University of Health Sciences, Gazi Yasargil Training 
      and Research Hospital, Diyarbakir, Turkey.
FAU - Donmezdil, Suleyman
AU  - Donmezdil S
AD  - Department of Psychiatry, University of Health Sciences, Gazi Yasargil Training 
      and Research Hospital, Diyarbakir, Turkey.
FAU - Jovicevic, Tatjana Vlaskovic
AU  - Jovicevic TV
AD  - Clinic for Mental Disorders "Dr Laza Lazarevic", Belgrade, Serbia.
FAU - Vojvodic, Petar
AU  - Vojvodic P
AD  - Clinic for Mental Disorders "Dr Laza Lazarevic", Belgrade, Serbia.
FAU - Lotti, Torello
AU  - Lotti T
AUID- ORCID: 0000-0003-0840-1936
AD  - Department of Dermatology, University of Rome "G. Marconi", Rome, Italy.
FAU - Vestita, Michelangelo
AU  - Vestita M
AUID- ORCID: 0000-0002-2203-0353
AD  - Unit of Plastic and Reconstructive Surgery, Department of Emergency and Organ 
      Transplantation, University of Bari, Bari, Italy.
AD  - Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, Massachusetts.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191014
PL  - United States
TA  - Dermatol Ther
JT  - Dermatologic therapy
JID - 9700070
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids)
RN  - 935E97BOY8 (Folic Acid)
RN  - EH28UP18IF (Isotretinoin)
SB  - IM
MH  - Acne Vulgaris/complications/drug therapy
MH  - Brain-Derived Neurotrophic Factor/blood/physiology
MH  - Depression/*drug therapy/etiology
MH  - Fatty Acids/administration & dosage/physiology
MH  - Folic Acid/*administration & dosage
MH  - Humans
MH  - Hyperhomocysteinemia/classification
MH  - Isotretinoin/*adverse effects
OTO - NOTNLM
OT  - depression
OT  - folic acid
OT  - low dose isotretinoin
EDAT- 2019/10/07 06:00
MHDA- 2020/05/19 06:00
CRDT- 2019/10/07 06:00
PHST- 2019/08/09 00:00 [received]
PHST- 2019/09/26 00:00 [accepted]
PHST- 2019/10/07 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2019/10/07 06:00 [entrez]
AID - 10.1111/dth.13104 [doi]
PST - ppublish
SO  - Dermatol Ther. 2019 Nov;32(6):e13104. doi: 10.1111/dth.13104. Epub 2019 Oct 14.