PMID- 31588073
OWN - NLM
STAT- MEDLINE
DCOM- 20200330
LR  - 20200330
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 81
IP  - 11
DP  - 2019 Nov 29
TI  - Possible anti-oxidative effects of long-term administration of Juzen-taiho-to in 
      dogs.
PG  - 1616-1620
LID - 10.1292/jvms.19-0380 [doi]
AB  - It is known that oxidative stress is related to disease in humans and dogs. Many 
      traditional Chinese medicines have been reported to have anti-oxidative effects, 
      but there are no reports that they have anti-oxidative effects in dogs. In this 
      study, we examined the anti-oxidative effects of Juzen-taiho-to, a traditional 
      Chinese medicine, in dogs. Five healthy female beagle dogs (38-41 months of age 
      weighing 8.6-10.7 kg) were orally administered Juzen-taiho-to at 450 mg/kg with 
      food for 28 days. Blood samples were taken from all five dogs on days 0, 7, 14, 
      21, and 28. Using the blood samples, improvement of the antioxidant level as 
      assessed by the biological antioxidant potential (BAP), reduced oxidative stress 
      level as assessed by derivatives of reactive oxygen metabolites (d-ROMs), and 
      improvement of blood fluidity were examined. Regarding the antioxidant level and 
      blood fluidity, no significant difference was observed, but the oxidative stress 
      level on days 14, 21, and 28 was significantly lower than that on day 0. Thus, 
      Juzen-taiho-to may have anti-oxidative effects in dogs by reducing oxidative 
      stress and be useful for oxidative stress-related diseases in dogs.
FAU - Shinohara, Yuta
AU  - Shinohara Y
AD  - Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty 
      of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 
      Fuchu, Tokyo 183-8509, Japan.
AD  - Pet Health & Food Division, Iskara Industry Co., Ltd., 1-14-2, Nihonbashi, 
      Chuo-ku, Tokyo 103-0027, Japan.
FAU - Oyama, Ayaka
AU  - Oyama A
AD  - Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty 
      of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 
      Fuchu, Tokyo 183-8509, Japan.
FAU - Usui, Tatsuya
AU  - Usui T
AD  - Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty 
      of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 
      Fuchu, Tokyo 183-8509, Japan.
FAU - Sasaki, Kazuaki
AU  - Sasaki K
AD  - Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty 
      of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 
      Fuchu, Tokyo 183-8509, Japan.
LA  - eng
PT  - Journal Article
DEP - 20191004
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Antioxidants)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (juzentaihoto)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antioxidants/*administration & dosage/analysis
MH  - Blood Viscosity/drug effects
MH  - Dogs
MH  - Drugs, Chinese Herbal/*administration & dosage
MH  - Female
MH  - Oxidative Stress/drug effects
MH  - Reactive Oxygen Species/blood
PMC - PMC6895616
OTO - NOTNLM
OT  - Juzen-taiho-to
OT  - anti-oxidative effect
OT  - dog
OT  - traditional Chinese medicine
EDAT- 2019/10/08 06:00
MHDA- 2020/03/31 06:00
PMCR- 2019/11/01
CRDT- 2019/10/08 06:00
PHST- 2019/10/08 06:00 [pubmed]
PHST- 2020/03/31 06:00 [medline]
PHST- 2019/10/08 06:00 [entrez]
PHST- 2019/11/01 00:00 [pmc-release]
AID - 19-0380 [pii]
AID - 10.1292/jvms.19-0380 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2019 Nov 29;81(11):1616-1620. doi: 10.1292/jvms.19-0380. Epub 2019 
      Oct 4.