PMID- 31588816
OWN - NLM
STAT- MEDLINE
DCOM- 20220214
LR  - 20220531
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 128
IP  - 1
DP  - 2022 Feb
TI  - The association between retinol-binding protein 4 and prediabetes in obese 
      patients with nonalcoholic fatty liver disease.
PG  - 217-222
LID - 10.1080/13813455.2019.1673429 [doi]
AB  - CONTEXT: Retinol-binding protein 4 (RBP4) is associated with visceral fat and 
      insulin resistance (IR) in obesity, type 2 diabetes mellitus (T2DM) and 
      nonalcoholic fatty liver disease (NAFLD), but some of these data remain 
      controversial. OBJECTIVE: This study evaluated the relationship between serum 
      RBP4 levels and prediabetes in obese patients with NAFLD. METHODS: A total of 79 
      obese NAFLD patients without (n = 41) and with prediabetes (n = 38) were 
      included. Serum RBP4 was measured using ELISA method. RESULTS: Higher RBP4 serum 
      levels were observed in patients with prediabetes, metabolic syndrome (MetS), or 
      dyslipidaemia. There was correlation between RBP4 levels and visceral adiposity 
      index (VAI), glucose, insulin, HOMA-IR, and Quicki index. RBP4 >/= 61 mcg/ml have 
      about 3.5-fold higher risk of prediabetes (OR 3.544, 95% CI 1.385-9.072, p=.008), 
      and RBP4 >/= 55 mcg/ml increased the risk for MetS approximately 3.1 times. 
      CONCLUSIONS: RBP4 is associated with increased risk for prediabetes and MetS in 
      obese patients with NAFLD.
FAU - Karamfilova, Vera
AU  - Karamfilova V
AD  - Department of Internal Medicine, Clinic of Endocrinology, University Hospital 
      "Alexandrovska", Medical University - Sofia, Sofia, Bulgaria.
FAU - Gateva, Antoaneta
AU  - Gateva A
AD  - Department of Internal Medicine, Clinic of Endocrinology, University Hospital 
      "Alexandrovska", Medical University - Sofia, Sofia, Bulgaria.
FAU - Alexiev, Asen
AU  - Alexiev A
AD  - Department of Internal Medicine, Clinic of Gastroenterology, University Hospital 
      "St. Ivan Rilski", Medical University - Sofia, Sofia, Bulgaria.
FAU - Zheleva, Nadejda
AU  - Zheleva N
AD  - Department of Internal Medicine, Clinic of Gastroenterology, University Hospital 
      "St. Ivan Rilski", Medical University - Sofia, Sofia, Bulgaria.
FAU - Velikova, Tsvetelina
AU  - Velikova T
AD  - Department of Clinical Immunology, University Hospital Lozenetz, Sofia, Bulgaria.
FAU - Ivanova-Boyanova, Radina
AU  - Ivanova-Boyanova R
AD  - Department of Endocrinology, Laboratory of Clinical Pathology, University 
      Hospital "St. Ivan Rilski", Medical University - Sofia, Sofia, Bulgaria.
FAU - Ivanova, Raya
AU  - Ivanova R
AD  - Department of Internal Medicine, Clinic of Cardiology, University Hospital 
      "Alexandrovska", Medical University - Sofia, Sofia, Bulgaria.
FAU - Cherkezov, Nikolay
AU  - Cherkezov N
AD  - Medical student, Medical Faculty, Medical University, Sofia, Bulgaria.
FAU - Kamenov, Zdravko
AU  - Kamenov Z
AD  - Department of Internal Medicine, Clinic of Endocrinology, University Hospital 
      "Alexandrovska", Medical University - Sofia, Sofia, Bulgaria.
FAU - Mateva, Ludmila
AU  - Mateva L
AD  - Department of Internal Medicine, Clinic of Gastroenterology, University Hospital 
      "St. Ivan Rilski", Medical University - Sofia, Sofia, Bulgaria.
LA  - eng
PT  - Journal Article
DEP - 20191007
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (RBP4 protein, human)
RN  - 0 (Retinol-Binding Proteins, Plasma)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Humans
MH  - *Insulin Resistance
MH  - *Non-alcoholic Fatty Liver Disease/complications
MH  - Obesity/complications
MH  - *Prediabetic State/complications
MH  - Retinol-Binding Proteins, Plasma/*metabolism
OTO - NOTNLM
OT  - Retinol-binding protein 4
OT  - metabolic syndrome
OT  - nonalcoholic fatty liver disease
OT  - obesity
OT  - prediabetes
EDAT- 2019/10/08 06:00
MHDA- 2022/02/15 06:00
CRDT- 2019/10/08 06:00
PHST- 2019/10/08 06:00 [pubmed]
PHST- 2022/02/15 06:00 [medline]
PHST- 2019/10/08 06:00 [entrez]
AID - 10.1080/13813455.2019.1673429 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2022 Feb;128(1):217-222. doi: 
      10.1080/13813455.2019.1673429. Epub 2019 Oct 7.