PMID- 31588854
OWN - NLM
STAT- MEDLINE
DCOM- 20200331
LR  - 20200331
IS  - 1753-4666 (Electronic)
IS  - 1753-4658 (Print)
IS  - 1753-4658 (Linking)
VI  - 13
DP  - 2019 Jan-Dec
TI  - High immunoglobulin E level is associated with increased readmission in children 
      with bronchopneumonia.
PG  - 1753466619879832
LID - 10.1177/1753466619879832 [doi]
LID - 1753466619879832
AB  - BACKGROUND: Increased immunoglobulin E (IgE) is associated with lower respiratory 
      tract infections. The study aimed to evaluate the association between IgE and the 
      rate of bronchopneumonia-related readmission within 12 months in children. 
      METHODS: A total of 1099 children aged over 1 year with bronchopneumonia, from 1 
      January 2015 to 31 December 2016, were enrolled. Unplanned readmissions within 12 
      months after discharge were observed. Multivariate regression analysis was used 
      to identify independent risk factors for rehospitalization. RESULTS: The rate of 
      rehospitalization was 11.4% (125/1099). Compared to the nonreadmission children, 
      IgE levels, the proportion of children with asthma and hospitalization duration 
      were significantly higher in the readmission children (p < 0.05). Compared to the 
      children with normal IgE (</= 165 IU/ml) levels, the risk of rehospitalization was 
      significantly higher in children with abnormal IgE [odds ratio (OR) 1.781, 95% 
      confidence interval (CI) 1.209-2.624, p = 0.004]. Children with IgE level more 
      than three times the upper limit had even higher risks of readmission (OR 2.037, 
      95%CI 1.172-3.540, p = 0.012). Meanwhile, the risk of readmission in children 
      with abnormal IgE combined with or without bronchial asthma was significantly 
      higher (OR 2.548 and 1.918, 95% CI 1.490-4.358 and 1.218-3.020, p = 0.001 and 
      0.005, respectively). CONCLUSIONS: Children aged over 1 year with 
      bronchopneumonia who had higher IgE levels are at increased risk for 
      rehospitalization within the first 12 months of the index hospitalization and IgE 
      level may be used as a predictor of rehospitalization in children with 
      bronchopneumonia.
FAU - You, Cun
AU  - You C
AD  - Department of Pediatrics, Minhang Branch, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Ran, Guo
AU  - Ran G
AD  - Department of Anesthesiology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Wu, Xiao
AU  - Wu X
AD  - Emergency Department, Jiading District Central Hospital Affiliated Shanghai 
      University of Medicine and Health Sciences, Shanghai, China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Jiuting Town Community Healthcare Center of Songjiang District, Shanghai, China.
FAU - Tian, Hua
AU  - Tian H
AD  - Jiuting Town Community Healthcare Center of Songjiang District, Shanghai, China.
FAU - Fan, Jiabao
AU  - Fan J
AD  - Department of Clinical Laboratory, Minhang Branch, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Yao, Zezhong
AU  - Yao Z
AD  - Department of pediatrics, Minhang Branch, Zhongshan Hospital, Fudan University, 
      No.170, Xinsong Rd, Minhang, Shanghai 201199, China.
FAU - Wang, Fei
AU  - Wang F
AUID- ORCID: 0000-0001-8908-5618
AD  - Emergency Department, Jiading District Central Hospital Affiliated Shanghai 
      University of Medicine & Health Sciences, No.1, Chengbei Rd, Jiading, Shanghai 
      201800, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ther Adv Respir Dis
JT  - Therapeutic advances in respiratory disease
JID - 101316317
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Biomarkers/blood
MH  - Bronchopneumonia/*blood/diagnosis/therapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Male
MH  - *Patient Readmission
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Up-Regulation
PMC - PMC6783659
OTO - NOTNLM
OT  - bronchial asthma
OT  - bronchopneumonia
OT  - immunoglobulin E
OT  - repeated hospitalization
COIS- Conflict of interest statement: The authors declare that they have no conflict of 
      interest.
EDAT- 2019/10/08 06:00
MHDA- 2020/04/01 06:00
PMCR- 2019/10/06
CRDT- 2019/10/08 06:00
PHST- 2019/10/08 06:00 [entrez]
PHST- 2019/10/08 06:00 [pubmed]
PHST- 2020/04/01 06:00 [medline]
PHST- 2019/10/06 00:00 [pmc-release]
AID - 10.1177_1753466619879832 [pii]
AID - 10.1177/1753466619879832 [doi]
PST - ppublish
SO  - Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619879832. doi: 
      10.1177/1753466619879832.