PMID- 31590774
OWN - NLM
STAT- MEDLINE
DCOM- 20191209
LR  - 20191217
IS  - 1879-3363 (Electronic)
IS  - 0025-326X (Linking)
VI  - 145
DP  - 2019 Aug
TI  - Associations between organohalogen exposure and thyroid- and steroid-related gene 
      responses in St. Lawrence Estuary belugas and minke whales.
PG  - 174-184
LID - S0025-326X(19)30388-1 [pii]
LID - 10.1016/j.marpolbul.2019.05.029 [doi]
AB  - Elevated concentrations of persistent organic pollutants (POPs) and emerging 
      halogenated flame retardants (HFRs) have been reported in tissues of the 
      endangered St. Lawrence Estuary (Canada) beluga population as well as in minke 
      whales visiting that same feeding area. This study examined the linkages between 
      blubber concentrations of POPs and emerging HFRs, and transcription in skin of 
      genes involved in the regulation of thyroid and steroid axes in belugas and minke 
      whales from the St. Lawrence Estuary. In belugas, concentrations of PCBs, OCs and 
      hexabromobenzene (HBB) were positively correlated with the transcription of 
      thyroid- and/or steroid-related genes, while Dec-604 CB concentrations were 
      negatively associated with the transcription of glucocorticoid and thyroid genes. 
      In minke whales, PBDE concentrations changed positively with Esrbeta transcript 
      levels and HBB concentrations negatively with Nr3c1 transcripts. Present results 
      suggest that several biological functions including reproduction and energetic 
      metabolism may represent potential targets for organohalogens in these whales.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Simond, Antoine E
AU  - Simond AE
AD  - Centre de recherche en toxicologie de l'environnement (TOXEN), Departement des 
      sciences biologiques, Universite du Quebec a Montreal, P.O. Box 8888, Succursale 
      Centre-ville, Montreal, QC H3C 3P8, Canada.
FAU - Houde, Magali
AU  - Houde M
AD  - Environment and Climate Change Canada, 105 McGill Street, Montreal, QC H2Y 2E7, 
      Canada.
FAU - Lesage, Veronique
AU  - Lesage V
AD  - Maurice Lamontagne Institute, Fisheries and Oceans Canada, P.O. Box 1000, 850 
      route de la Mer, Mont-Joli, QC G5H 3Z4, Canada.
FAU - Michaud, Robert
AU  - Michaud R
AD  - Groupe de Recherche et d'Education sur les Mammiferes Marins (GREMM), 870 avenue 
      Salaberry, Bureau R24, Quebec, QC G1R 2T9, Canada.
FAU - Zbinden, Dany
AU  - Zbinden D
AD  - Meriscope, 833 rue du Quai, Portneuf-sur-Mer, QC G0T 1P0, Canada.
FAU - Verreault, Jonathan
AU  - Verreault J
AD  - Centre de recherche en toxicologie de l'environnement (TOXEN), Departement des 
      sciences biologiques, Universite du Quebec a Montreal, P.O. Box 8888, Succursale 
      Centre-ville, Montreal, QC H3C 3P8, Canada. Electronic address: 
      verreault.jonathan@uqam.ca.
LA  - eng
PT  - Journal Article
DEP - 20190524
PL  - England
TA  - Mar Pollut Bull
JT  - Marine pollution bulletin
JID - 0260231
RN  - 0 (Flame Retardants)
RN  - 0 (Steroids)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adipose Tissue/chemistry
MH  - Animals
MH  - Beluga Whale/*genetics/metabolism
MH  - Ecotoxicology
MH  - Estuaries
MH  - Female
MH  - Flame Retardants/analysis/toxicity
MH  - Gene Expression Regulation/*drug effects
MH  - Male
MH  - Minke Whale/*genetics/metabolism
MH  - Polychlorinated Biphenyls/analysis/toxicity
MH  - Quebec
MH  - Steroids/metabolism
MH  - Thyroid Gland/drug effects
MH  - Water Pollutants, Chemical/analysis/*toxicity
OTO - NOTNLM
OT  - Cetacean
OT  - Flame retardant
OT  - Gene transcription
OT  - Organochlorine
OT  - Steroid
OT  - Thyroid
EDAT- 2019/10/09 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/10/09 06:00
PHST- 2018/12/10 00:00 [received]
PHST- 2019/05/12 00:00 [revised]
PHST- 2019/05/13 00:00 [accepted]
PHST- 2019/10/09 06:00 [entrez]
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
AID - S0025-326X(19)30388-1 [pii]
AID - 10.1016/j.marpolbul.2019.05.029 [doi]
PST - ppublish
SO  - Mar Pollut Bull. 2019 Aug;145:174-184. doi: 10.1016/j.marpolbul.2019.05.029. Epub 
      2019 May 24.