PMID- 31591054
OWN - NLM
STAT- MEDLINE
DCOM- 20200325
LR  - 20200325
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 215
IP  - 11
DP  - 2019 Nov
TI  - Key genes associated with diabetes mellitus and hepatocellular carcinoma.
PG  - 152510
LID - S0344-0338(19)30755-1 [pii]
LID - 10.1016/j.prp.2019.152510 [doi]
AB  - Accumulating evidence indicates a strong correlation between type 2 diabetes 
      mellitus (T2DM) and hepatocellular carcinoma (HCC), but the underlying 
      pathophysiology is still elusive. We aimed to identify unrecognized but important 
      genes and pathways related to T2DM and HCC by bioinformatic analysis. The 
      GSE64998 and GSE15653 datasets (for T2DM), the GSE121248 dataset and the Cancer 
      Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) dataset (for HCC) were 
      downloaded. Differential expression analysis, functional and pathway enrichment 
      analysis, protein-protein interaction (PPI) network construction, survival 
      analysis, transcription factor (TF) prediction, and correlation of gene 
      expression with methylation and tumour-infiltrating immune cells were conducted. 
      Nine genes, namely, CDNF, CRELD2, DNAJB11, DTL, GINS2, MANF, PDIA4, PDIA6, and 
      VCP, were recognized as hub genes. Enrichment analysis revealed several enriched 
      terms and pathways. Transcription factors such as Kruppel-like factor 6, abnormal 
      methylation and immune dysregulation might help explain the dysregulation of hub 
      genes. Our study identified nine hub genes that might play a critical role in 
      both T2DM and HCC. However, more studies are warranted to clarify the mechanisms 
      of these genes.
CI  - Copyright (c) 2019 Elsevier GmbH. All rights reserved.
FAU - Liu, Gao-Min
AU  - Liu GM
AD  - Department of Hepatobiliary Surgery, Meizhou People's Hospital, No. 38 Huangtang 
      Road, Meizhou 514000, China. Electronic address: liugaom88@foxmail.com.
FAU - Zeng, Hua-Dong
AU  - Zeng HD
AD  - Department of Hepatobiliary Surgery, Meizhou People's Hospital, No. 38 Huangtang 
      Road, Meizhou 514000, China. Electronic address: zenghdht@163.com.
FAU - Zhang, Cai-Yun
AU  - Zhang CY
AD  - Department of Hepatobiliary Surgery, Meizhou People's Hospital, No. 38 Huangtang 
      Road, Meizhou 514000, China. Electronic address: zhangcyht@163.com.
FAU - Xu, Ji-Wei
AU  - Xu JW
AD  - Department of Hepatobiliary Surgery, Meizhou People's Hospital, No. 38 Huangtang 
      Road, Meizhou 514000, China. Electronic address: javeeht@63.com.
LA  - eng
PT  - Journal Article
DEP - 20190706
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
SB  - IM
MH  - Carcinoma, Hepatocellular/*genetics
MH  - Computational Biology
MH  - Databases, Genetic
MH  - Diabetes Mellitus/*genetics
MH  - Humans
MH  - Liver Neoplasms/*genetics
OTO - NOTNLM
OT  - Bioinformatic
OT  - Diabetes
OT  - GEO
OT  - Hepatocellular carcinoma
OT  - TCGA
EDAT- 2019/10/09 06:00
MHDA- 2020/03/26 06:00
CRDT- 2019/10/09 06:00
PHST- 2019/04/22 00:00 [received]
PHST- 2019/05/27 00:00 [revised]
PHST- 2019/06/20 00:00 [accepted]
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2020/03/26 06:00 [medline]
PHST- 2019/10/09 06:00 [entrez]
AID - S0344-0338(19)30755-1 [pii]
AID - 10.1016/j.prp.2019.152510 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2019 Nov;215(11):152510. doi: 10.1016/j.prp.2019.152510. Epub 
      2019 Jul 6.