PMID- 31591335
OWN - NLM
STAT- MEDLINE
DCOM- 20200224
LR  - 20200224
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 16
IP  - 19
DP  - 2019 Oct 7
TI  - Effect of Paecilomyces tenuipes Extract on Testosterone-Induced Benign Prostatic 
      Hyperplasia in Sprague-Dawley Rats.
LID - 10.3390/ijerph16193764 [doi]
LID - 3764
AB  - : Benign prostatic hyperplasia (BPH) is one of the major public health concerns, 
      which has a high prevalence rate and causes significant decline in men's quality 
      of life. BPH is highly related to sexual hormone metabolism and aging. In 
      particular, dihydrotestosterone (DHT), to which testosterone is modified by 
      5alpha-reductase (5AR), has a significant effect on BPH development. DHT binds to an 
      androgen receptor (AR) and steroid receptor coactivator 1 (SRC-1); then, it 
      induces the proliferation of a prostate cell and expression of prostate specific 
      antigen (PSA). Paecilomyces tenuipes (P. tenuipes) is a mushroom that has been 
      popularized by the artificial cultivation of fruiting bodies based on silkworms 
      by researchers from the Republic of Korea. In a previous study, we identified the 
      effect of PE on PSA mRNA expression in LNCaP cells. This suggests that PE may 
      have an inhibitory effect on androgen signaling. Therefore, we confirmed the 
      expression of androgen signaling-related factors, such as AR, SRC-1, and PSA in 
      LNCaP. Furthermore, we confirmed the androgen signaling inhibitory effect of PE 
      using the testosterone propionate (TP)-induced BPH rat model. A BPH rat model was 
      established with a four-week treatment of daily subcutaneous injections of 
      testosterone propionate (TP, 3 mg/kg) dissolved in corn oil after castration. The 
      rats in the treatment group were orally gavaged P. tenuipes extract (PE), 
      finasteride (Fi), or saw palmetto extract (Saw) with TP injection. DHT induced an 
      increase in the expression levels of AR, SRC-1, and PSA proteins in LNCaP cells. 
      On the contrary, the PE treatment reduced the expression levels. In vivo, the BPH 
      group showed an increase in prostate size compared with the control group. The PE 
      gavaged group showed a decrease in prostate size compared with the BPH group. In 
      addition, the protein expressions of AR, 5AR2, and PSA were significantly lower 
      in the PE gavaged group than BPH group in prostate tissue. These results suggest 
      the beneficial effects of PE on BPH via the modulation of AR signaling pathway.
FAU - Choi, Young-Jin
AU  - Choi YJ
AD  - Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk 
      University, Chungju 27478, Korea.
FAU - Kim, Eun-Kyung
AU  - Kim EK
AD  - Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk 
      University, Chungju 27478, Korea.
FAU - Fan, Meiqi
AU  - Fan M
AD  - Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk 
      University, Chungju 27478, Korea.
FAU - Tang, Yujiao
AU  - Tang Y
AD  - Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk 
      University, Chungju 27478, Korea.
AD  - School of Bio-science and Food Engineering, Changchun University of Science and 
      Technology, Changchun 130-600, China.
FAU - Hwang, Young Joung
AU  - Hwang YJ
AD  - Department of Food Science & Culinary, International University of Korea, Jinju 
      52833, Korea.
FAU - Sung, Si-Heung
AU  - Sung SH
AD  - Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk 
      University, Chungju 27478, Korea. shsung@kku.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191007
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Plant Extracts)
RN  - 0 (Receptors, Androgen)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Male
MH  - Paecilomyces/*chemistry
MH  - Plant Extracts/*pharmacology
MH  - Prostatic Hyperplasia/*drug therapy/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Androgen/metabolism
MH  - Testosterone/*metabolism
PMC - PMC6801653
OTO - NOTNLM
OT  - Paecilomyces tenuipes
OT  - benign prostatic hyperplasia
OT  - testosterone
COIS- The authors declare no conflict of interest.
EDAT- 2019/10/09 06:00
MHDA- 2020/02/25 06:00
PMCR- 2019/10/01
CRDT- 2019/10/09 06:00
PHST- 2019/08/13 00:00 [received]
PHST- 2019/10/03 00:00 [revised]
PHST- 2019/10/03 00:00 [accepted]
PHST- 2019/10/09 06:00 [entrez]
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2020/02/25 06:00 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - ijerph16193764 [pii]
AID - ijerph-16-03764 [pii]
AID - 10.3390/ijerph16193764 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2019 Oct 7;16(19):3764. doi: 
      10.3390/ijerph16193764.