PMID- 31591828
OWN - NLM
STAT- MEDLINE
DCOM- 20200903
LR  - 20231014
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 7
IP  - 19
DP  - 2019 Oct
TI  - Risk assessment of macrovascular and microvascular events in patients with type 2 
      diabetes by analyzing the amplitude variation of the fourth harmonic component of 
      radial pulse wave.
PG  - e14252
LID - 10.14814/phy2.14252 [doi]
LID - e14252
AB  - This investigation explored the hypothesis that whether the coefficient of 
      variation of the fourth harmonic amplitude of the radial pulse wave (C4CV) 
      predicts the risk of macrovascular and microvascular events in patients with type 
      2 diabetes mellitus (T2DM). Radial pulse wave and brachial blood pressure were 
      measured at baseline in 2324 patients with T2DM and C4CV was calculated using the 
      Fourier series method. Macrovascular and microvascular events during follow-up 
      were determined by medical records. We plotted the Kaplan-Meier curve and 
      performed a Cox proportional hazard model and a log-rank test to estimate the 
      effectiveness of C4CV as a risk predictor. We divided patients into quartile 
      groups based on C4CV (<4.3%, 4.3% to 6.8%, 6.8% to 11.4%, and >11.4%). Compared 
      with patients with C4CV < 4.3%, patients with C4CV> 11.4% had a double incidence 
      of macrovascular events (hazard ratio, 2.13; 95% CI, 1.70-2.67) and microvascular 
      events (hazard ratio, 2.08; 95% CI, 1.67-2.58), and the incidence of 
      cardiovascular death was three times (hazard ratio, 3.03; 95% CI, 1.10-8.83). The 
      Cox regression analysis demonstrated that the risk of both macrovascular and 
      microvascular outcomes increases with the increase in quartile level of C4CV 
      value (P < 0.0001). These associations remained after adjustment for age, gender, 
      smoking, systolic blood pressure, diastolic blood pressure, dyslipidemia, 
      diabetes duration, Hba1c, and cardiovascular disease (P < 0.0001). C4CV is a 
      novel independent predictor of cardiovascular mortality, macrovascular events, 
      and microvascular events in patients with T2DM.
CI  - (c) 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on 
      behalf of The Physiological Society and the American Physiological Society.
FAU - Liao, Kuo-Meng
AU  - Liao KM
AD  - Division of Endocrinology & Metabolism of Zhongxiao Branch of Taipei City 
      Hospital, Taipei, Taiwan.
FAU - Chang, Chi-Wei
AU  - Chang CW
AUID- ORCID: 0000-0002-8331-7729
AD  - MiiAnn Medical Research Center, Taipei, Taiwan.
FAU - Wang, Sheng-Hung
AU  - Wang SH
AD  - MiiAnn Medical Research Center, Taipei, Taiwan.
FAU - Chang, Yi-Ting
AU  - Chang YT
AD  - Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore.
FAU - Chen, Ying-Chun
AU  - Chen YC
AD  - Division of Endocrinology & Metabolism of Zhongxiao Branch of Taipei City 
      Hospital, Taipei, Taiwan.
FAU - Wang, Gin-Chung
AU  - Wang GC
AD  - JinMu Health Technology, Taipei, Taiwan.
LA  - eng
SI  - ISRCTN/ISRCTN14306167
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
SB  - IM
EIN - Physiol Rep. 2019 Dec;7(23):e14311. PMID: 31858751
MH  - Aged
MH  - Blood Pressure/*physiology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Assessment/methods
PMC - PMC6779930
OTO - NOTNLM
OT  - Harmonic analysis
OT  - macrovascular events
OT  - microvascular events
OT  - pulse wave analysis
OT  - radial pulse wave
OT  - risk factor
COIS- The authors declare that they have no competitive interests.
EDAT- 2019/10/09 06:00
MHDA- 2020/09/04 06:00
PMCR- 2019/10/07
CRDT- 2019/10/09 06:00
PHST- 2019/07/22 00:00 [received]
PHST- 2019/09/05 00:00 [revised]
PHST- 2019/09/08 00:00 [accepted]
PHST- 2019/10/09 06:00 [entrez]
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2020/09/04 06:00 [medline]
PHST- 2019/10/07 00:00 [pmc-release]
AID - PHY214252 [pii]
AID - 10.14814/phy2.14252 [doi]
PST - ppublish
SO  - Physiol Rep. 2019 Oct;7(19):e14252. doi: 10.14814/phy2.14252.