PMID- 31592153
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 1734-9338 (Print)
IS  - 1897-4295 (Electronic)
IS  - 1734-9338 (Linking)
VI  - 15
IP  - 3
DP  - 2019
TI  - Ischemic postconditioning reduces infarct size and microvascular obstruction zone 
      in acute ST-elevation myocardial infarction - a randomized study.
PG  - 292-300
LID - 10.5114/aic.2019.87882 [doi]
AB  - INTRODUCTION: Ischemic postconditiong (postcon) has been reported to reduce 
      infarct size in ST-segment myocardial infarction (STEMI). However, recently a few 
      other studies did not show any effect of postcon or suggested that it may even be 
      harmful. AIM: We sought to assess whether postcon could reduce infarct size (IS) 
      and the microvascular obstruction (MVO) zone in early presenters with STEMI. 
      MATERIAL AND METHODS: Seventy-four STEMI patients treated with primary coronary 
      intervention (PCI) < 4 h from symptoms onset were randomly assigned to the 
      postcon group (n = 37) or standard PCI group (n = 37). Postcon was performed 
      immediately after obtaining reperfusion with 4 balloon occlusions, each lasting 
      60 s, followed by 60 seconds of reperfusion. Cardiac magnetic resonance was 
      performed in all subjects within 48 to 96 h after admission. To evaluate the 
      infarct size and MVO, the late gadolinium enhancement (LGE) technique was used. 
      Infarct size was defined as an area greater than 50% of the maximal signal 
      intensity within LGE. MVO was defined as the area of the absence or 
      hypoenhancement of contrast surrounded by LGE. Infarct size and MVO were 
      determined by planimetry and the summation of discs method. RESULTS: Postcon was 
      associated with significantly smaller IS (16.42 +/-9.6 vs. 31.2 +/-22.2 g; p = 0.007) 
      and higher ejection fraction (59.8 +/-9.2% vs. 52.3 +/-10.2%). The extent of MVO was 
      significantly lower in the postcon group in comparison to the control group (0.76 
      +/-1.4 g vs. 2.2 +/-3.2 g; p = 0.03). CONCLUSIONS: In early presenters with STEMI 
      postcon could significantly reduce infarct size and limit reperfusion injury.
CI  - Copyright: (c) 2019 Termedia Sp. z o. o.
FAU - Araszkiewicz, Aleksander
AU  - Araszkiewicz A
AD  - Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
FAU - Grygier, Marek
AU  - Grygier M
AD  - Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
FAU - Pyda, Malgorzta
AU  - Pyda M
AD  - Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
FAU - Rajewska, Justyna
AU  - Rajewska J
AD  - Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
FAU - Michalak, Michal
AU  - Michalak M
AD  - Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
FAU - Slawek-Szmyt, Sylwia
AU  - Slawek-Szmyt S
AD  - Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
FAU - Lesiak, Maciej
AU  - Lesiak M
AD  - Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
LA  - eng
PT  - Journal Article
DEP - 20190918
PL  - Poland
TA  - Postepy Kardiol Interwencyjnej
JT  - Postepy w kardiologii interwencyjnej = Advances in interventional cardiology
JID - 101272671
PMC - PMC6777191
OTO - NOTNLM
OT  - ST-segment elevation myocardial infarction
OT  - microvascular obstruction
OT  - postconditioning
COIS- The authors declare no conflict of interest.
EDAT- 2019/10/09 06:00
MHDA- 2019/10/09 06:01
PMCR- 2019/01/01
CRDT- 2019/10/09 06:00
PHST- 2019/01/24 00:00 [received]
PHST- 2019/04/14 00:00 [accepted]
PHST- 2019/10/09 06:00 [entrez]
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2019/10/09 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 37665 [pii]
AID - 10.5114/aic.2019.87882 [doi]
PST - ppublish
SO  - Postepy Kardiol Interwencyjnej. 2019;15(3):292-300. doi: 10.5114/aic.2019.87882. 
      Epub 2019 Sep 18.