PMID- 31592167
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 1734-9338 (Print)
IS  - 1897-4295 (Electronic)
IS  - 1734-9338 (Linking)
VI  - 15
IP  - 3
DP  - 2019
TI  - The influence of cardiac resynchronization therapy on subjective and objective 
      parameters of sleep, and their association with the function of the autonomous 
      nervous system.
PG  - 357-363
LID - 10.5114/aic.2019.87892 [doi]
AB  - INTRODUCTION: Cardiac resynchronization therapy (CRT) was a breakthrough in the 
      treatment of heart failure, but data regarding the effect of this therapy on 
      numerous disorders associated with heart failure are limited. AIM: To assess the 
      impact of CRT on sleep breathing disorders, and to determine the relationship 
      between the changes in the autonomous nervous system and sleep disorders after 
      CRT. MATERIAL AND METHODS: The study included 55 patients with chronic heart 
      failure stable for at least last 3 months, in New York Heart Association (NYHA) 
      class III or IV despite optimal medical therapy, with a reduced left ventricular 
      ejection fraction (LVEF) </= 35%, QRS complex duration >/= 120 ms, and sinus rhythm. 
      Before and 3 months after implementation of CRT echocardiography, 6-minute walk 
      test (6MWT), polysomnography with the Pittsburgh Sleep Quality Index (PSQI) 
      questionnaire and the Epworth Sleepiness Scale (ESS) were performed. Also 
      baroreflex sensitivity (BRS) was evaluated. RESULTS: After implementation of CRT, 
      the values of the apnea-hypopnea index (AHI), apnea index (AI), and central and 
      mixed apnea indexes (CAI, MAI) were statistically significantly reduced. The 
      strongest negative correlations were demonstrated for changes in CAI and changes 
      in BRS. An improvement in sleep quality, daytime sleepiness, LVEF, NYHA class, 
      and 6MWT was observed and was the most strongly associated with the improvement 
      in CAI, too. CONCLUSIONS: CRT has a beneficial effect on subjective and objective 
      features of sleep, as well as on the function of the autonomous nervous system. 
      In addition, patients with heart failure and coexisting central sleep apnea may 
      benefit most from this therapy.
CI  - Copyright: (c) 2019 Termedia Sp. z o. o.
FAU - Przybyla, Anna
AU  - Przybyla A
AD  - 1 Department of Cardiology, Interventional Electrocardiology and Arterial 
      Hypertension, Jagiellonian University Medical College, Krakow, Poland.
FAU - Czarnecka, Danuta
AU  - Czarnecka D
AD  - 1 Department of Cardiology, Interventional Electrocardiology and Arterial 
      Hypertension, Jagiellonian University Medical College, Krakow, Poland.
LA  - eng
PT  - Journal Article
DEP - 20190918
PL  - Poland
TA  - Postepy Kardiol Interwencyjnej
JT  - Postepy w kardiologii interwencyjnej = Advances in interventional cardiology
JID - 101272671
PMC - PMC6777186
OTO - NOTNLM
OT  - baroreflex
OT  - biventricular pacing
OT  - heart failure
OT  - sleep-disordered breathing
COIS- The authors declare no conflict of interest.
EDAT- 2019/10/09 06:00
MHDA- 2019/10/09 06:01
PMCR- 2019/01/01
CRDT- 2019/10/09 06:00
PHST- 2019/04/15 00:00 [received]
PHST- 2019/06/13 00:00 [accepted]
PHST- 2019/10/09 06:00 [entrez]
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2019/10/09 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 37674 [pii]
AID - 10.5114/aic.2019.87892 [doi]
PST - ppublish
SO  - Postepy Kardiol Interwencyjnej. 2019;15(3):357-363. doi: 10.5114/aic.2019.87892. 
      Epub 2019 Sep 18.