PMID- 31592929
OWN - NLM
STAT- MEDLINE
DCOM- 20201111
LR  - 20201111
IS  - 1932-751X (Electronic)
IS  - 1932-7501 (Linking)
VI  - 39
IP  - 6
DP  - 2019 Nov
TI  - The Effects of a 10-wk Outpatient Pulmonary Rehabilitation Program on Exercise 
      Performance, Muscle Strength, Soluble Biomarkers, and Quality of Life in Patients 
      With Pulmonary Hypertension.
PG  - 397-402
LID - 10.1097/HCR.0000000000000443 [doi]
AB  - PURPOSE: Pulmonary arterial hypertension (PAH) is characterized by right 
      ventricular failure, leading to exertional dyspnea, skeletal muscle weakness, and 
      poor quality of life (QOL). Apart from treatment with PAH-specific drugs, 
      guidelines recommend pulmonary rehabilitation (PR). Clinical PR programs have 
      shown improvement in functional capacity and QOL. However, little is known about 
      the effectiveness of an outpatient PR program. The aim of our study was to assess 
      effectiveness of a multidisciplinary outpatient PR program. METHODS: Patients 
      with PAH or chronic thromboembolic pulmonary hypertension (CTEPH), who were in a 
      stable condition on optimized drug therapy, followed a 10-wk outpatient program 
      in a rehabilitation center. The PR program was designed to improve exercise 
      capacity and health status by means of low load cycling, walking, and muscle 
      training twice a week combined with psychological counseling. QOL was measured by 
      the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) questionnaire. 
      RESULTS: Twenty-one patients (13 women) with PAH (n = 16) or CTEPH (n = 5) 
      completed the study. All patients were in New York Heart Association (NYHA) 
      functional class III, and their mean age was 45 +/- 16 yr. After PR, the mean 
      cycling endurance time increased by 4.4 min (P < .001), 6-min walk distance by 
      12.2 m (P < .05), and maximum inspiratory pressure by 5.8 cm H2O (P = .01). 
      Skeletal muscle function increased significantly. The CAMPHOR questionnaire 
      demonstrated significant decrease in symptoms and improvement in QOL. Soluble 
      biomarkers did not show any change before and after PR. CONCLUSIONS: Outpatient 
      PR could be an effective instrument to improve exercise capacity and health 
      status in patients with PAH or CTEPH.
FAU - Koudstaal, Thomas
AU  - Koudstaal T
AD  - Departments of Pulmonary Medicine (Drs Koudstaal, van den Toorn, Chandoesing, and 
      Boomars and Ms Wapenaar) and Cardiology (Dr van den Bosch), Erasmus MC, 
      University Medical Center Rotterdam, the Netherlands; and Pulmonary 
      Rehabilitation Centre, Revant, Breda, the Netherlands (Dr van Ranst and Mr 
      Beesems). Both T. Koudstaal and M. Wapenaar contributed equally and share first 
      authorship for the article.
FAU - Wapenaar, Monique
AU  - Wapenaar M
FAU - van Ranst, Dirk
AU  - van Ranst D
FAU - Beesems, Ruud
AU  - Beesems R
FAU - van den Toorn, Leon
AU  - van den Toorn L
FAU - van den Bosch, Annemien
AU  - van den Bosch A
FAU - Chandoesing, Prewesh
AU  - Chandoesing P
FAU - Boomars, Karin
AU  - Boomars K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiopulm Rehabil Prev
JT  - Journal of cardiopulmonary rehabilitation and prevention
JID - 101291247
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers
MH  - Cohort Studies
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*physiopathology/*rehabilitation
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength/*physiology
MH  - Outpatients/*statistics & numerical data
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2019/10/09 06:00
MHDA- 2020/11/12 06:00
CRDT- 2019/10/09 06:00
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2020/11/12 06:00 [medline]
PHST- 2019/10/09 06:00 [entrez]
AID - 10.1097/HCR.0000000000000443 [doi]
PST - ppublish
SO  - J Cardiopulm Rehabil Prev. 2019 Nov;39(6):397-402. doi: 
      10.1097/HCR.0000000000000443.