PMID- 31593339
OWN - NLM
STAT- MEDLINE
DCOM- 20201020
LR  - 20201020
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 130
IP  - 7
DP  - 2020 Jul
TI  - The minimal clinically important difference of the dyspnea index in 
      laryngotracheal stenosis.
PG  - 1775-1779
LID - 10.1002/lary.28331 [doi]
AB  - OBJECTIVE: The Dyspnea Index (DI) is a validated patient-reported outcome (PRO) 
      instrument that has been used in the management of laryngotracheal stenosis 
      (LTS). The minimal clinically important difference (MCID) is an established 
      concept to help determine the change in a PRO instrument that reflects meaningful 
      change for the patient. It is not known what change in the DI is of clinical 
      significance in airway surgery. This study aims to determine the MCID for the DI 
      in patients undergoing surgical treatment for LTS. METHODS: This is a prospective 
      cohort study in which 26 patients with LTS completed the DI (score range 0 to 40) 
      before and 6 to 8 weeks postoperatively, in addition to a Global Ratings Change 
      Questionnaire (GRCQ), scored from -7 to +7, at the postoperative interval. A 
      hypothesis test was carried out to test the association between GRCQ and change 
      in DI. The MCID for change in DI was determined using anchor-based analysis. 
      RESULTS: Overall mean change in DI was -11, and mean change in GRCQ was +5. 
      Change in DI scores were significantly different among the improvement and no 
      improvement groups (P value <0.002). Area under the receiver operating curve was 
      0.92, demonstrating high discriminatory ability of the change in DI score. A 
      change of -4 was determined to be the threshold that discriminated between 
      significant improvement and no improvement. CONCLUSION: A decrease of 4 in the DI 
      can be considered as the MCID for patients with LTS after surgical treatment. 
      LEVEL OF EVIDENCE: 2b Laryngoscope, 130:1775-1779, 2020.
CI  - (c) 2019 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Gray, Alan J
AU  - Gray AJ
AUID- ORCID: 0000-0002-7957-1038
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Washington, 
      Seattle, Washington, U.S.A.
FAU - Huston, Molly
AU  - Huston M
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Washington, 
      Seattle, Washington, U.S.A.
FAU - Didericksen, Devin
AU  - Didericksen D
AD  - Department of Statistics, University of Washington, Seattle, Washington, U.S.A.
FAU - Meyer, Tanya K
AU  - Meyer TK
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Washington, 
      Seattle, Washington, U.S.A.
FAU - Merati, Albert
AU  - Merati A
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Washington, 
      Seattle, Washington, U.S.A.
FAU - Brisebois, Simon
AU  - Brisebois S
AD  - Department of Surgery, Otolaryngology-Head and Neck Division, University of 
      Sherbrooke, Sherbrooke, Quebec, Canada.
LA  - eng
PT  - Journal Article
DEP - 20191008
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Disability Evaluation
MH  - Dyspnea/*diagnosis/etiology/rehabilitation
MH  - Feasibility Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Laryngoscopy
MH  - Laryngostenosis/*complications/diagnosis/surgery
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - *Patient Reported Outcome Measures
MH  - Prospective Studies
MH  - Quality of Life
MH  - Surveys and Questionnaires
MH  - Tracheal Stenosis/*complications/diagnosis/surgery
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Minimal clinically important difference
OT  - airway surgery
OT  - dyspnea
OT  - laryngotracheal stenosis
EDAT- 2019/10/09 06:00
MHDA- 2020/10/21 06:00
CRDT- 2019/10/09 06:00
PHST- 2019/04/18 00:00 [received]
PHST- 2019/08/12 00:00 [revised]
PHST- 2019/09/03 00:00 [accepted]
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/10/09 06:00 [entrez]
AID - 10.1002/lary.28331 [doi]
PST - ppublish
SO  - Laryngoscope. 2020 Jul;130(7):1775-1779. doi: 10.1002/lary.28331. Epub 2019 Oct 
      8.