PMID- 31593574
OWN - NLM
STAT- MEDLINE
DCOM- 20200316
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 10
DP  - 2019
TI  - Determination of factors affecting medication adherence in type 2 diabetes 
      mellitus patients using a nationwide claim-based database in Japan.
PG  - e0223431
LID - 10.1371/journal.pone.0223431 [doi]
LID - e0223431
AB  - BACKGROUND: The extent of medication adherence in patients with type 2 diabetes 
      mellitus (T2DM) several years after starting treatment with hypoglycemic agents 
      remains unknown. Most previous work on medication adherence targeting this group 
      of patients has been undertaken across a single year or is questionnaire based. 
      This study aimed to determine medication adherence status and factors affecting 
      adherence 3 years after initiation of hypoglycemic agents, using a nationwide 
      medical claim-based database in Japan. METHODS: This retrospective study was 
      conducted on data from 884 subjects with T2DM to better understand medication 
      adherence, the effects of polypharmacy, and other factors. We also investigated 
      the effects of medication nonadherence on hemoglobin A1c levels. Proportion of 
      days covered was defined as the number of days for which a hypoglycemic agent was 
      prescribed and in the patient's possession to the number of days in the 
      observation period. A proportion of days covered >/=0.8 were considered adherent, 
      and those with a value <0.8 as nonadherence. Polypharmacy was defined as taking 
      >/=5 medications. RESULTS: Of the 884 patients investigated, 440 were considered 
      adherent during the study period. Significant factors related to adherence 
      included number of medications (3 or 4, or >/=5), male sex, age 50-<60 years, and 
      total number of visits >/=17. Medication adherence was also a factor related to 
      patients with hemoglobin A1c values < 7.0% at the end of the observation period. 
      CONCLUSIONS: We surveyed medication adherence for 3 years with post medication 
      initiation, and found that subjects aged 50-<60 years, those with >/=3 concomitant 
      medications, and those with a total number of visits >/=17 were more likely to be 
      adherent and persistent, and more likely to continue their hypoglycemic agents. A 
      high degree of medication adherence was found to have a positive influence on 
      hemoglobin A1c levels.
FAU - Horii, Takeshi
AU  - Horii T
AUID- ORCID: 0000-0002-5465-4531
AD  - Research and Education Center for Clinical Pharmacy, Division of Clinical 
      Pharmacy, Laboratory of Pharmacy Practice and Science 1, Kitasato University 
      School of Pharmacy, Kanagawa, Japan.
FAU - Momo, Kenji
AU  - Momo K
AUID- ORCID: 0000-0001-9856-0097
AD  - Department of Pharmacy, The Research Hospital, The Institute of Medical Science, 
      The University of Tokyo, Tokyo, Japan.
AD  - Department of Hospital Pharmaceutics, School of pharmacy, Showa University, 
      Tokyo, Japan.
FAU - Yasu, Takeo
AU  - Yasu T
AD  - Department of Medicinal Therapy Research, Pharmaceutical Education and Research 
      Center, Meiji Pharmaceutical University, Tokyo, Japan.
FAU - Kabeya, Yusuke
AU  - Kabeya Y
AD  - Department of Home Care Medicine, Sowa Hospital, Kanagawa, Japan.
FAU - Atsuda, Koichiro
AU  - Atsuda K
AD  - Research and Education Center for Clinical Pharmacy, Division of Clinical 
      Pharmacy, Laboratory of Pharmacy Practice and Science 1, Kitasato University 
      School of Pharmacy, Kanagawa, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191008
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Biomarkers
MH  - Databases, Factual
MH  - Diabetes Mellitus, Type 2/*epidemiology/therapy
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Medication Adherence/*statistics & numerical data
MH  - Middle Aged
MH  - Polypharmacy
MH  - Public Health Surveillance
MH  - Retrospective Studies
MH  - Young Adult
PMC - PMC6782087
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/10/09 06:00
MHDA- 2020/03/17 06:00
PMCR- 2019/10/08
CRDT- 2019/10/09 06:00
PHST- 2019/03/10 00:00 [received]
PHST- 2019/09/20 00:00 [accepted]
PHST- 2019/10/09 06:00 [entrez]
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2020/03/17 06:00 [medline]
PHST- 2019/10/08 00:00 [pmc-release]
AID - PONE-D-19-06992 [pii]
AID - 10.1371/journal.pone.0223431 [doi]
PST - epublish
SO  - PLoS One. 2019 Oct 8;14(10):e0223431. doi: 10.1371/journal.pone.0223431. 
      eCollection 2019.