PMID- 31593744
OWN - NLM
STAT- MEDLINE
DCOM- 20200220
LR  - 20200220
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 157
DP  - 2019 Nov
TI  - Clinical characteristics of diabetic nephropathy in patients with type 2 diabetic 
      mellitus manifesting heavy proteinuria: A retrospective analysis of 220 cases.
PG  - 107874
LID - S0168-8227(19)30893-9 [pii]
LID - 10.1016/j.diabres.2019.107874 [doi]
AB  - AIMS: To determine the predictability of diagnosing diabetic nephropathy (DN) 
      versus non-diabetic renal disease (NDRD) from clinical and laboratory data in 
      Chinese patients with type 2 diabetes mellitus (T2DM) manifesting heavy 
      proteinuria. METHODS: We retrospectively analyzed the clinical and laboratory 
      data of patients with T2DM manifesting heavy proteinuria who underwent renal 
      biopsy from January 2014 to December 2017. RESULTS: According to renal biopsy, 
      220 patients were finally enrolled, including 109 cases diagnosed with DN alone 
      (49.55%), 94 with NDRD alone (42.73%) and 17 with DN plus superimposed NDRD 
      (7.73%). Multivariate analysis showed the significant risk factors for DN alone 
      were age, duration of diabetes, presence of retinopathy, 24-h proteinuria, serum 
      albumin and SBP. Presence of retinopathy achieved the highest overall diagnostic 
      efficiency with the area under the curve of 0.852, sensitivity of 78.9% and 
      specificity of 91.5%. The combined diagnosis with four indicators (duration of 
      diabetes, retinopathy, SBP, and serum albumin) showed the area under the curve of 
      0.938, sensitivity of 88.1% and specificity of 87.2%. CONCLUSIONS: The prevalence 
      of DN is high in patients with T2DM manifesting heavy proteinuria. Renal biopsy 
      should be performed in diabetics in the atypical clinical scenario.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Wang, Xiaoyi
AU  - Wang X
AD  - Kidney Disease Center, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Hangzhou 310003, China; Department of Nephrology, The First 
      Affiliated Hospital of Huzhou Teachers College, The First People's Hospital of 
      Huzhou, Zhejiang Province 313000, China.
FAU - Li, Jie
AU  - Li J
AD  - Department of Nephrology, Lishui Central Hospital, Zhejiang Province 323000, 
      China.
FAU - Huo, Lixia
AU  - Huo L
AD  - Department of Central Laboratory, The First Affiliated Hospital of Huzhou 
      Teachers College, The First People's Hospital of Huzhou, Zhejiang Province 
      313000, China.
FAU - Feng, Yuehua
AU  - Feng Y
AD  - Department of Nephrology, The First Affiliated Hospital of Huzhou Teachers 
      College, The First People's Hospital of Huzhou, Zhejiang Province 313000, China.
FAU - Ren, Lingyan
AU  - Ren L
AD  - Department of Nephrology, The First Affiliated Hospital of Huzhou Teachers 
      College, The First People's Hospital of Huzhou, Zhejiang Province 313000, China.
FAU - Yao, Xiner
AU  - Yao X
AD  - Department of Nephrology, The First Affiliated Hospital of Huzhou Teachers 
      College, The First People's Hospital of Huzhou, Zhejiang Province 313000, China.
FAU - Jiang, Hong
AU  - Jiang H
AD  - Kidney Disease Center, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Hangzhou 310003, China.
FAU - Lv, Rong
AU  - Lv R
AD  - Kidney Disease Center, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Hangzhou 310003, China.
FAU - Zhu, Ming
AU  - Zhu M
AD  - Department of Nephrology, The First Affiliated Hospital of Huzhou Teachers 
      College, The First People's Hospital of Huzhou, Zhejiang Province 313000, China. 
      Electronic address: zming0850@sina.com.
FAU - Chen, Jianghua
AU  - Chen J
AD  - Kidney Disease Center, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Hangzhou 310003, China. Electronic address: 
      chenjianghua@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191005
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Diabetic Nephropathies/*etiology
MH  - Female
MH  - Humans
MH  - Kidney/*pathology
MH  - Male
MH  - Middle Aged
MH  - Proteinuria/*complications
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Clinical characteristics
OT  - Diabetic nephropathy
OT  - Non-diabetic renal disease
OT  - Type 2 diabetes mellitus
EDAT- 2019/10/09 06:00
MHDA- 2020/02/23 06:00
CRDT- 2019/10/09 06:00
PHST- 2019/06/27 00:00 [received]
PHST- 2019/09/18 00:00 [revised]
PHST- 2019/09/30 00:00 [accepted]
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2020/02/23 06:00 [medline]
PHST- 2019/10/09 06:00 [entrez]
AID - S0168-8227(19)30893-9 [pii]
AID - 10.1016/j.diabres.2019.107874 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2019 Nov;157:107874. doi: 10.1016/j.diabres.2019.107874. 
      Epub 2019 Oct 5.