PMID- 31593745
OWN - NLM
STAT- MEDLINE
DCOM- 20200220
LR  - 20200220
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 157
DP  - 2019 Nov
TI  - Effects of hypertension on cerebral cortical thickness alterations in patients 
      with type 2 diabetes.
PG  - 107872
LID - S0168-8227(19)30937-4 [pii]
LID - 10.1016/j.diabres.2019.107872 [doi]
AB  - AIMS: Although hypertension (HTN) is the high comorbidity of Type 2 diabetes 
      mellitus (T2DM) and known to be a vascular risk factor for brain damage, the 
      effects of HTN on brain function in T2DM patients are not well understood. 
      Present study was performed to investigate whether HTN might accelerate the 
      Cerebral cortical thickness (CT) alterations in patients with T2DM. METHODS: We 
      enrolled 35 participants with only T2DM, 25 T2DM patients with HTN (HT2DM) and 28 
      healthy controls (HCs). The cognitive function was assessed and brain image data 
      was collected then the CT was calculated for each participant. Partial 
      correlations between the CT of each brain region and standard laboratory testing 
      data and neuropsychological scale scores were also analyzed. Multivariable 
      regression analysis was performed to evaluated the vascular risk factors and 
      brain regions with different CT in HT2DM patients. RESULTS: Cognitive impairment 
      is associated with thinning of the cerebral cortical thickness reduction in T2DM 
      patients. CT thinning in the left inferior parietal lobe, left posterior 
      cingulate and right precuneus were observed in HT2DM group relative to only T2DM 
      group. Furthermore, the CT decreasing in the right precuneus was negatively 
      correlated with duration of HTN. CONCLUSION: The current study revealed that 
      coexistent HTN may accelerate the CT reduction in T2DM patients.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Shi, Li
AU  - Shi L
AD  - Department of Endocrinology, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Cheng, Yuqi
AU  - Cheng Y
AD  - Department of Psychiatry, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Xu, Yushan
AU  - Xu Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Shen, Zonglin
AU  - Shen Z
AD  - Department of Psychiatry, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Lu, Yi
AU  - Lu Y
AD  - Department of MRI, The First Affiliated Hospital of Kunming Medical University, 
      Kunming, China.
FAU - Zhou, Cong
AU  - Zhou C
AD  - Department of Psychiatry, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Jiang, Linling
AU  - Jiang L
AD  - Department of Psychiatry, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Zhu, Fangyu
AU  - Zhu F
AD  - Department of MRI, The First Affiliated Hospital of Kunming Medical University, 
      Kunming, China.
FAU - Xu, Xiufeng
AU  - Xu X
AD  - Department of Psychiatry, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China. Electronic address: xfxu2004@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20191005
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Cerebral Cortex/*abnormalities
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Hypertension/*complications
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Cerebral cortical thickness
OT  - Hypertension
OT  - Type 2 diabetes
EDAT- 2019/10/09 06:00
MHDA- 2020/02/23 06:00
CRDT- 2019/10/09 06:00
PHST- 2019/07/30 00:00 [received]
PHST- 2019/08/31 00:00 [revised]
PHST- 2019/09/30 00:00 [accepted]
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2020/02/23 06:00 [medline]
PHST- 2019/10/09 06:00 [entrez]
AID - S0168-8227(19)30937-4 [pii]
AID - 10.1016/j.diabres.2019.107872 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2019 Nov;157:107872. doi: 10.1016/j.diabres.2019.107872. 
      Epub 2019 Oct 5.