PMID- 31594042
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20191104
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 48
IP  - 10
DP  - 2019 Oct 8
TI  - [Invasive breast lobular carcinoma with extracellular mucin: a 
      clinicopathological analysis].
PG  - 779-783
LID - 10.3760/cma.j.issn.0529-5807.2019.10.006 [doi]
AB  - Objective: To study the clinicopathological features of invasive lobular 
      carcinoma (ILC) of the breast with extracellular mucin and outcomes of patients. 
      Method: Clinicopathological features and clinical follow-up (39-123 months and a 
      median follow-up of 55 months) of seven ILC with extracellular mucin were 
      obtained. Hematoxylin-and-eosin (H&E) and immunohistochemistry (IHC) stained 
      sections were reviewed, and fluorescence in situ hybridization (FISH) assay was 
      performed for tumors with HER2 IHC 2+. Patient prognosis was analyzed and 
      literatures related to ILC with extracellular mucin were reviewed. Results: All 
      seven patients were female, aged from 43 to 73 years (median age, 55 years). The 
      tumors ranged in size from 1 to 5 cm (median size 2 cm). All seven cases were of 
      histological grade 2. Most areas of the tumors presented with the morphology of 
      classic ILC, and variable amount of extracellular mucin were observed focally. In 
      six cases, part of the tumor cells contained intracellular mucin, and the nucleus 
      were pushed to one side of the cells, creating the impression of signet-ring 
      cells. Two patients had lymph node metastases at diagnosis, and developed liver 
      and bone metastases at 38th and 48th month, respectively, after surgery, and died 
      at 48th and 123th month, respectively. While the other five patients, except one 
      lost to follow-up, had been disease-free during the follow-up period. IHC results 
      showed estrogen receptor (ER) and progesterone receptor (PR) positivity in 7/7 
      and 6/7 cases, respectively. Tumors of six patients were HER2 IHC 0/1+. The 
      remaining one was HER2 IHC 2+, while FISH assay revealed HER2 gene amplification 
      in that tumor. The proportion of cases with HER2-positivity was 1/7. The 
      proliferation index Ki-67 ranged from less than 5% to 30%, and Ki-67 less than or 
      equal to 10% were in 5/7 cases. According to the 2013 St. Gallen International 
      Expert Consensus on breast cancer, all tumors were of luminal types; of those, 
      two were luminal A and five were luminal B. Conclusions: ILC with extracellular 
      mucin tends to occur in women over 50 years old. All tumors in the study are 
      grade 2 classic ILC, with signet-ring cells as a common feature. All seven tumors 
      are classified as luminal types, with luminal B as the main molecular subtype.
FAU - Lyu, H
AU  - Lyu H
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Fu, L M
AU  - Fu LM
AD  - Department of Pathology, Binzhou People's Hospital, Shandong Province, Binzhou 
      256600, China.
FAU - Tu, X Y
AU  - Tu XY
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Lu, H F
AU  - Lu HF
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Shui, R H
AU  - Shui RH
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Cheng, Y F
AU  - Cheng YF
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Li, X Q
AU  - Li XQ
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Yang, W T
AU  - Yang WT
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Mucins)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/analysis
MH  - Breast Neoplasms/*pathology
MH  - Carcinoma, Lobular/*pathology
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Mucins/*analysis
MH  - Prognosis
MH  - Receptor, ErbB-2/genetics
OTO - NOTNLM
OT  - Breast neoplasms
OT  - Extracellular mucin
OT  - Molecular typing
EDAT- 2019/10/09 06:00
MHDA- 2019/11/05 06:00
CRDT- 2019/10/10 06:00
PHST- 2019/10/10 06:00 [entrez]
PHST- 2019/10/09 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2019.10.006 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2019 Oct 8;48(10):779-783. doi: 
      10.3760/cma.j.issn.0529-5807.2019.10.006.