PMID- 31595798
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20210709
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 45
IP  - 5
DP  - 2020 May
TI  - Reduced Retinal Microvascular Density Related to Activity Status and Serum 
      Antibodies in Patients with Graves' Ophthalmopathy.
PG  - 576-584
LID - 10.1080/02713683.2019.1675177 [doi]
AB  - Objective: To investigate changes in retinal capillary density (RCD) that occur 
      in Graves' ophthalmopathy (GO) and explore their association with the clinical 
      manifestations for GO.Material and Methods: A total of 125 participants (93 GO 
      patients and 32 normal subjects) were enrolled. All participants underwent 
      ophthalmology and endocrinology examinations. Retinal microvasculature was imaged 
      by spectral domain optical coherence tomographic angiography (OCT-A). The RCDs in 
      the superficial and deep retinal capillary plexuses (SRCP and DRCP) were 
      quantified by the custom software from the OCT-A images, which were divided into 
      total annular zones (TAZ) and four quadrants. Multiple linear regression analysis 
      was used to explore the associations between RCD and the relevant 
      factors.Results: Significant reduction was seen in the TAZ zone in SRCP and DRCP 
      of GO group (P < .05) when compared to the healthy subjects; significant 
      differences remained after adjustment of vascular relevant factors. According to 
      the univariate analysis, the relevant factors of higher IOP, larger proptosis, 
      higher clinical activity scoring (CAS), thyroid stimulating hormone-receptor 
      autoantibodies (TRAb), and (131)I therapy were significantly associated with 
      decreased RCDs in GO patients (P < .05). Multivariate linear regression analysis 
      showed that CAS and TRAb were the most important relevant factors for decreased 
      RCDs.Conclusions: The RCD of GO patients was significantly decreased compared to 
      the healthy controls. The activity status and serum antibodies associated with GO 
      were the relevant factors for reduced RCD.
FAU - Wu, Yufei
AU  - Wu Y
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
AD  - Department of Ophthalmology, Yinzhou Hospital Affiliated to Medical School of 
      Ningbo University, The Eye Hospital of Wenzhou Medical University (Ningbo 
      Branch), Ningbo, Zhejiang, China.
FAU - Tu, Yunhai
AU  - Tu Y
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Bao, Lulu
AU  - Bao L
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Wu, Chaoming
AU  - Wu C
AD  - The Second Affiliated Hospital & Yuying Children's Hospital, Wenzhou Medical 
      University, Wenzhou, Zhejiang, China.
FAU - Zheng, Jingwei
AU  - Zheng J
AUID- ORCID: 0000-0002-2594-5014
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Wang, Jianhua
AU  - Wang J
AD  - Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 
      Miami, FL, USA.
AD  - Electrical and Computer Engineering, University of Miami, Miami, FL, USA.
FAU - Lu, Fan
AU  - Lu F
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Shen, Meixiao
AU  - Shen M
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Chen, Qi
AU  - Chen Q
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191009
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Thyrotropin)
SB  - IM
MH  - Adult
MH  - Autoantibodies/*blood
MH  - Capillaries/diagnostic imaging/pathology
MH  - Exophthalmos/pathology
MH  - Female
MH  - Fluorescein Angiography
MH  - Graves Ophthalmopathy/*blood/diagnosis/physiopathology
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - *Microvascular Density
MH  - Middle Aged
MH  - Receptors, Thyrotropin/*immunology
MH  - Retinal Vessels/diagnostic imaging/*pathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
OTO - NOTNLM
OT  - Graves' ophthalmopathy
OT  - Retina
OT  - density
OT  - microvasculature
OT  - optical coherence tomography angiography
EDAT- 2019/10/10 06:00
MHDA- 2021/07/10 06:00
CRDT- 2019/10/10 06:00
PHST- 2019/10/10 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2019/10/10 06:00 [entrez]
AID - 10.1080/02713683.2019.1675177 [doi]
PST - ppublish
SO  - Curr Eye Res. 2020 May;45(5):576-584. doi: 10.1080/02713683.2019.1675177. Epub 
      2019 Oct 9.