PMID- 31597084 OWN - NLM STAT- MEDLINE DCOM- 20210428 LR - 20210428 IS - 1872-7549 (Electronic) IS - 0166-4328 (Linking) VI - 378 DP - 2020 Jan 27 TI - Functional connectivity underpinning changes in life-space mobility in older adults with mild cognitive impairment: A 12-month prospective study. PG - 112216 LID - S0166-4328(19)30660-6 [pii] LID - 10.1016/j.bbr.2019.112216 [doi] AB - Subtle changes in mobility exist among older adults with mild cognitive impairment (MCI). Life-space mobility defines the frequency and extent of movements in the environment, and lower life-space mobility is associated with adverse health outcomes and MCI. Currently, the underlying mechanism of this association is not well understood. This study examined the functional neural correlates of life-space mobility in community-dwelling older adults with MCI. We first conducted a cross-sectional investigation of the association between resting-state default mode network (DMN) and sensori-motor network (SMN) connectivity and life-space mobility (assessed by the Life-Space Assessment (LSA)) among 60 community-dwelling older adults with MCI using aggregated data from two studies - baseline data from a randomized controlled trial (n = 20) and baseline data from a 12-month prospective study (n = 40). Using data from the 12-month prospective study (n = 35), we then examined whether baseline internetwork connectivity predicts reduced life-space mobility over 12 months. The cross-sectional analysis showed higher DMN-SMN connectivity was associated with lower LSA scores after adjusting for baseline global cognitive function and baseline age (p < 0.01). A significant reduction in LSA scores was observed in the 35 participants of the 12-month prospective study (paired sample t-test mean change = -6.53, p = 0.01). Greater baseline DMN-SMN connectivity was associated with greater reduction in life-space mobility at 12 months (p = 0.04) after adjusting for baseline age, global cognitive function, and LSA score. Our findings suggest that lower and reduced life-space mobility in older adults with MCI may be due to altered functional architecture of the brain such that normal neuro-cognitive motor behaviours may be disrupted. CI - Copyright (c) 2019. Published by Elsevier B.V. FAU - Hsu, Chun Liang AU - Hsu CL AD - Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada; Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada; Djavad Mowafaghian Center for Brain Health, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Center for Hip Health and Mobility, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Crockett, Rachel AU - Crockett R AD - Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada; Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada; Djavad Mowafaghian Center for Brain Health, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Center for Hip Health and Mobility, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Chan, Patrick AU - Chan P AD - Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada; Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada; Djavad Mowafaghian Center for Brain Health, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Center for Hip Health and Mobility, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Brinke, Lisanne Ten AU - Brinke LT AD - Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada; Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada; Djavad Mowafaghian Center for Brain Health, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Center for Hip Health and Mobility, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Doherty, Stephanie AU - Doherty S AD - Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada; Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada; Djavad Mowafaghian Center for Brain Health, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Center for Hip Health and Mobility, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Liu-Ambrose, Teresa AU - Liu-Ambrose T AD - Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada; Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada; Djavad Mowafaghian Center for Brain Health, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Center for Hip Health and Mobility, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: teresa.ambrose@ubc.ca. LA - eng GR - MOB-93373/Canadian Institute of Health Research/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191006 PL - Netherlands TA - Behav Brain Res JT - Behavioural brain research JID - 8004872 SB - IM MH - *Activities of Daily Living MH - Aged MH - Aged, 80 and over MH - Cognitive Dysfunction/*physiopathology MH - *Connectome MH - Cross-Sectional Studies MH - Default Mode Network/diagnostic imaging/*physiopathology MH - Female MH - Humans MH - Independent Living MH - Magnetic Resonance Imaging MH - Male MH - Mobility Limitation MH - Motor Activity/*physiology MH - Nerve Net/diagnostic imaging/*physiopathology MH - Prospective Studies MH - Randomized Controlled Trials as Topic MH - Sensorimotor Cortex/diagnostic imaging/*physiopathology OTO - NOTNLM OT - Life-space mobility OT - Older adults OT - Resting-state functional magnetic resonance imaging EDAT- 2019/10/10 06:00 MHDA- 2021/04/29 06:00 CRDT- 2019/10/10 06:00 PHST- 2019/04/29 00:00 [received] PHST- 2019/08/16 00:00 [revised] PHST- 2019/09/05 00:00 [accepted] PHST- 2019/10/10 06:00 [pubmed] PHST- 2021/04/29 06:00 [medline] PHST- 2019/10/10 06:00 [entrez] AID - S0166-4328(19)30660-6 [pii] AID - 10.1016/j.bbr.2019.112216 [doi] PST - ppublish SO - Behav Brain Res. 2020 Jan 27;378:112216. doi: 10.1016/j.bbr.2019.112216. Epub 2019 Oct 6.