PMID- 31597363
OWN - NLM
STAT- MEDLINE
DCOM- 20200214
LR  - 20200214
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 24
IP  - 19
DP  - 2019 Oct 8
TI  - Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu "Kadsura coccinea" 
      Stems.
LID - 10.3390/molecules24193628 [doi]
LID - 3628
AB  - Two new triterpenoids, named kadsuricoccins A and B, together with three known 
      ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea 
      (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their 
      structures were elucidated by comprehensive analyses of mass spectrometry (MS) 
      and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy 
      components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman's 
      Method was conducted, kadsuricoccins A and B showed activity with the AChE 
      inhibit index (AII) up to 68.96% +/- 0.19% and 57.8% +/- 0.11% at 94 nM (compared 
      with positive control tacrine AII 79.80% +/- 0.20%, 9.4 nM), respectively.
FAU - Huang, Sheng Zhuo
AU  - Huang SZ
AD  - Hainan Key Laboratory for Research and Development of Natural Products from Li 
      Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese 
      Academy of Tropical Agriculture Sciences, Haikou 571101, China. 
      huangshengzhuo@itbb.org.cn.
FAU - Duan, Lin Ping
AU  - Duan LP
AD  - College of Food Science and technology, Nanjing Agricultural University, Nanjing 
      210095, China. 15854846579@163.com.
FAU - Wang, Hao
AU  - Wang H
AUID- ORCID: 0000-0001-6838-6550
AD  - Hainan Key Laboratory for Research and Development of Natural Products from Li 
      Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese 
      Academy of Tropical Agriculture Sciences, Haikou 571101, China. 
      wanghao@itbb.org.cn.
FAU - Mei, Wen Li
AU  - Mei WL
AD  - Hainan Key Laboratory for Research and Development of Natural Products from Li 
      Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese 
      Academy of Tropical Agriculture Sciences, Haikou 571101, China. 
      meiwenli@itbb.org.cn.
FAU - Dai, Hao Fu
AU  - Dai HF
AD  - Hainan Key Laboratory for Research and Development of Natural Products from Li 
      Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese 
      Academy of Tropical Agriculture Sciences, Haikou 571101, China. 
      daihaofu@itbb.org.cn.
LA  - eng
GR  - CARS-21/China Agriculture Research System/
GR  - NFZX2018/Financial Fund of the Ministry of Agriculture and Rural Affairs, P. R. 
      of China/
GR  - ZDYF2019029/Hainan Province Key Research and Development Program/
PT  - Journal Article
DEP - 20191008
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Cholinesterase Inhibitors/chemistry/*isolation & purification/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drugs, Chinese Herbal/chemistry/*isolation & purification/*pharmacology
MH  - Enzyme Activation/drug effects
MH  - Kadsura/*chemistry
MH  - Magnetic Resonance Spectroscopy
MH  - Molecular Structure
MH  - Plant Stems/*chemistry
PMC - PMC6804138
OTO - NOTNLM
OT  - AChE inhibitor
OT  - Kadsura coccinea
OT  - Schisandraceae
OT  - triterpenoid
COIS- All the authors of this manuscript state that they have no conflict of interest.
EDAT- 2019/10/11 06:00
MHDA- 2020/02/15 06:00
PMCR- 2019/10/08
CRDT- 2019/10/11 06:00
PHST- 2019/09/11 00:00 [received]
PHST- 2019/09/29 00:00 [revised]
PHST- 2019/10/07 00:00 [accepted]
PHST- 2019/10/11 06:00 [entrez]
PHST- 2019/10/11 06:00 [pubmed]
PHST- 2020/02/15 06:00 [medline]
PHST- 2019/10/08 00:00 [pmc-release]
AID - molecules24193628 [pii]
AID - molecules-24-03628 [pii]
AID - 10.3390/molecules24193628 [doi]
PST - epublish
SO  - Molecules. 2019 Oct 8;24(19):3628. doi: 10.3390/molecules24193628.