PMID- 3159797
OWN - NLM
STAT- MEDLINE
DCOM- 19850819
LR  - 20071114
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 135
IP  - 2
DP  - 1985 Aug
TI  - Tolerance to azobenzenearsonate: idiotype-specific suppression, B cell dominance, 
      and clonal elimination.
PG  - 886-91
AB  - Twenty to 70% of the antibody molecules produced by individual A/J mice in 
      response to azobenzenearsonate (ABA) bear a particular idiotype termed the major 
      cross-reactive idiotype (CRI). Mice that were made tolerant to ABA by injection 
      of ABA coupled to human gamma-globulin show a decrease in production of 
      ABA-specific antibody and a preferential loss of the major CRI. In the 
      experiments reported here, we have used adoptive cell transfers and splenic 
      fragment culture assays to study the mechanism(s) involved in the tolerance to 
      ABA, with emphasis on the preferential loss of the CRI. These studies show that 
      the decrease in total anti-ABA after the induction of tolerance is the result of 
      a decrease in the number of ABA-responsive B cells independent of CRI expression. 
      The preferential loss of the CRI is due to idiotype-specific T cell suppression 
      and/or B cell dominance. In addition, it is demonstrated that immunization in the 
      presence of idiotype-specific suppression converts a normally immunogenic 
      stimulus into a tolerogenic signal, resulting in a decrease in the absolute 
      number of CRI+ B cell precursors.
FAU - Collins, E T
AU  - Collins ET
FAU - Hershey, E D
AU  - Hershey ED
FAU - Benjamin, D C
AU  - Benjamin DC
LA  - eng
GR  - 5-T32-CA09109/CA/NCI NIH HHS/United States
GR  - CA24431/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Azo Compounds)
RN  - 0 (Immunoglobulin Idiotypes)
RN  - 7334-23-8 (p-Azobenzenearsonate)
SB  - IM
MH  - Animals
MH  - Antibody Specificity
MH  - Azo Compounds/*immunology
MH  - B-Lymphocytes/*immunology/transplantation
MH  - Cell Count
MH  - Clone Cells/immunology
MH  - *Immune Tolerance
MH  - Immunization, Passive
MH  - Immunoglobulin Idiotypes/*biosynthesis
MH  - Lymphocyte Activation/radiation effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred A
MH  - Spleen/cytology
MH  - Stem Cells
MH  - T-Lymphocytes, Regulatory/*immunology/transplantation
MH  - p-Azobenzenearsonate/*immunology
EDAT- 1985/08/01 00:00
MHDA- 1985/08/01 00:01
CRDT- 1985/08/01 00:00
PHST- 1985/08/01 00:00 [pubmed]
PHST- 1985/08/01 00:01 [medline]
PHST- 1985/08/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1985 Aug;135(2):886-91.