PMID- 31598144
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1837-9664 (Print)
IS  - 1837-9664 (Electronic)
IS  - 1837-9664 (Linking)
VI  - 10
IP  - 20
DP  - 2019
TI  - The association of HLA/KIR genes with non-small cell lung cancer (adenocarcinoma) 
      in a Han Chinese population.
PG  - 4731-4738
LID - 10.7150/jca.33566 [doi]
AB  - The host immune system plays a crucial role in the surveillance, recognition and 
      elimination of tumor cells. Recent studies found that Human lymphocyte antigen 
      class I (HLA I) genes, Killer cell immunoglobulin-like receptor (KIR) genes and 
      HLA/KIR combinations play a role in the defense against tumor cells. To evaluated 
      the associations between HLA I genes, KIR genes and HLA/KIR combinations and 
      non-small cell lung cancer (NSCLC) in a Chinese Han population, a total of 229 
      patients with NSCLC (adenocarcinoma) and 217 healthy individuals were studied. 
      Our results showed that the HLA-C*08:01 allele occurred at a significantly higher 
      frequency in the NSCLCs compared with the controls (P=0.034). The HLA haplotype 
      frequencies bearing HLA-A, -B, and -C loci between the NSCLC and control groups 
      were not different (P>0.05). And there were no differences in the KIR gene, 
      genotype and haplotype frequencies between the NSCLC and control groups (P>0.05). 
      Also, there were no differences between the HLA/KIR combinations in the KIR3D 
      genes and HLA-A3/A11, HLA-Bw4 ligands and KIR2D genes and HLA-C1/C2 ligands 
      between the NSCLC and control groups (P>0.05). Our results indicate that the 
      HLA-C*08:01 allele could be a risk factor for NSCLC (adenocarcinoma) in the 
      Chinese Han population (OR=2.395; 95% CI: 1.359-4.221).
CI  - (c) The author(s).
FAU - Li, Yingfu
AU  - Li Y
AD  - Department of Geriatrics, The No.1 Affiliated Hospital of Kunming Medical 
      University, Kunming 650032, China.
FAU - Liu, Shuyuan
AU  - Liu S
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming 650118, China.
FAU - Hong, Chao
AU  - Hong C
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming 650118, China.
FAU - Ma, Qianli
AU  - Ma Q
AD  - Department of Thoracic Surgery, The No.3 Affiliated Hospital of Kunming Medical 
      University, Kunming 650118, China.
FAU - Tan, Fang
AU  - Tan F
AD  - Department of Geriatrics, The No.1 Affiliated Hospital of Kunming Medical 
      University, Kunming 650032, China.
FAU - Liu, Chengxiu
AU  - Liu C
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming 650118, China.
FAU - Kusnierczyk, Piotr
AU  - Kusnierczyk P
AD  - Laboratory of Immunogenetics and Tissue Immunology, Ludwik Hirszfeld Institute of 
      Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
FAU - Li, Chuanyin
AU  - Li C
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming 650118, China.
FAU - Shi, Li
AU  - Shi L
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming 650118, China.
FAU - Yao, Yufeng
AU  - Yao Y
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming 650118, China.
LA  - eng
PT  - Journal Article
DEP - 20190820
PL  - Australia
TA  - J Cancer
JT  - Journal of Cancer
JID - 101535920
PMC - PMC6775512
OTO - NOTNLM
OT  - KIR
OT  - Chinese Han population
OT  - HLA
OT  - HLA/KIR combination
OT  - non-small cell lung cancer
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2019/10/11 06:00
MHDA- 2019/10/11 06:01
PMCR- 2019/01/01
CRDT- 2019/10/11 06:00
PHST- 2019/01/28 00:00 [received]
PHST- 2019/06/26 00:00 [accepted]
PHST- 2019/10/11 06:00 [entrez]
PHST- 2019/10/11 06:00 [pubmed]
PHST- 2019/10/11 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - jcav10p4731 [pii]
AID - 10.7150/jca.33566 [doi]
PST - epublish
SO  - J Cancer. 2019 Aug 20;10(20):4731-4738. doi: 10.7150/jca.33566. eCollection 2019.