PMID- 31598596
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2618-6500 (Electronic)
IS  - 2148-5046 (Print)
IS  - 2148-5046 (Linking)
VI  - 34
IP  - 3
DP  - 2019 Sep
TI  - Systemic Lupus Erythematosus and Angioedema: A Cross-Sectional Study From the 
      National Inpatient Sample.
PG  - 301-307
LID - 10.5606/ArchRheumatol.2019.7149 [doi]
AB  - OBJECTIVES: This cross-sectional study aims to investigate the odds of developing 
      angioedema (AE) in systemic lupus erythematosus (SLE) populations compared to 
      non-SLE populations in hospital settings in the United States using a nationwide 
      database. MATERIALS AND METHODS: We used the data from the National Inpatient 
      Sample for the years 2012 to 2014. We constructed two models for multivariate 
      logistic regression analysis. Model 1 was designed to adjust demographic 
      information, while model 2 included each factor in model 1 and additionally 
      accounted for AE-related comorbidities. RESULTS: A total of 90,485 
      hospitalizations with an AE diagnosis were identified for the years 2012 to 2014, 
      among which 1,505 hospitalizations had both SLE and AE. Compared to those without 
      SLE, AE patients with SLE were younger and included more females. In AE 
      hospitalizations, SLE was associated with higher odds of AE-related comorbidities 
      including atopic disorder, leukocytoclastic vasculitis, eosinophilia, and 
      infections. SLE was associated with higher odds of AE both as all inpatient 
      diagnosis and as principal diagnosis (unadjusted odds ratio [OR] 3.24, 95% 
      confidence interval [CI] 2.87-3.63, p<0.001, model 1 adjusted OR 2.54, 95% CI 
      2.26-2.86, p<0.001, model 2 adjusted OR 1.71, 95% CI 1.51-1.93, p<0.001). 
      CONCLUSION: Our study demonstrates that SLE is associated with higher odds of 
      having AE, including severe AE as the principal reason for inpatient admission. 
      SLE is possibly an independent risk factor for AE.
CI  - Copyright (c) 2019, Turkish League Against Rheumatism.
FAU - Luo, Yiming
AU  - Luo Y
AD  - Department of Medicine, Mount Sinai St. Luke's and Mount Sinai West Hospitals, 
      New York, United States.
FAU - Fan, Xiaowen
AU  - Fan X
AD  - Department of Medicine, Mount Sinai St. Luke's and Mount Sinai West Hospitals, 
      New York, United States.
FAU - Jiang, Changchuan
AU  - Jiang C
AD  - Department of Medicine, Mount Sinai St. Luke's and Mount Sinai West Hospitals, 
      New York, United States.
FAU - Ramos-Rodriguez, Alvaro
AU  - Ramos-Rodriguez A
AD  - Department of Medicine, Mount Sinai St. Luke's and Mount Sinai West Hospitals, 
      New York, United States.
FAU - Wen, Yumeng
AU  - Wen Y
AD  - Department of Medicine, Mount Sinai St. Luke's and Mount Sinai West Hospitals, 
      New York, United States.
FAU - Zhang, Jianglin
AU  - Zhang J
AD  - Department of Rheumatology and Immunology, China Pla General Hospital, Beijing, 
      China.
FAU - Huang, Feng
AU  - Huang F
AD  - Department of Respiratory Medicine, China Pla General Hospital, Beijing, China.
FAU - Guan, Xizhou
AU  - Guan X
AD  - Department of Respiratory Medicine, China Pla General Hospital, Beijing, China.
FAU - Xu, Jiehui
AU  - Xu J
AD  - Department of Medicine, Weill Cornell Medical College, New York, United States.
LA  - eng
PT  - Journal Article
DEP - 20190128
PL  - Turkey
TA  - Arch Rheumatol
JT  - Archives of rheumatology
JID - 101639000
PMC - PMC6768776
OTO - NOTNLM
OT  - Angioedema
OT  - National Inpatient Sample
OT  - cross-sectional study
OT  - epidemiology
OT  - systemic lupus erythematosus
COIS- Conflict of Interest: The authors declared no conflicts of interest with respect 
      to the authorship and/or publication of this article.
EDAT- 2019/10/11 06:00
MHDA- 2019/10/11 06:01
PMCR- 2019/01/28
CRDT- 2019/10/11 06:00
PHST- 2018/08/18 00:00 [received]
PHST- 2018/11/20 00:00 [accepted]
PHST- 2019/10/11 06:00 [entrez]
PHST- 2019/10/11 06:00 [pubmed]
PHST- 2019/10/11 06:01 [medline]
PHST- 2019/01/28 00:00 [pmc-release]
AID - 10.5606/ArchRheumatol.2019.7149 [doi]
PST - epublish
SO  - Arch Rheumatol. 2019 Jan 28;34(3):301-307. doi: 10.5606/ArchRheumatol.2019.7149. 
      eCollection 2019 Sep.