PMID- 31599465
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20210628
IS  - 1098-2302 (Electronic)
IS  - 0012-1630 (Linking)
VI  - 62
IP  - 4
DP  - 2020 May
TI  - Own or dam's genotype? Classical colony breeding may bias spontaneous and 
      stress-challenged activity in DAT-mutant rats.
PG  - 505-518
LID - 10.1002/dev.21927 [doi]
AB  - There is considerable interest in understanding what makes an individual 
      vulnerable or resilient to the deleterious effects of stressful events. From 
      candidate genes, dopamine (DA) and dopamine transporter (DAT) have been linked to 
      anxiety, depression, and post-traumatic stress disorder. We investigated role of 
      DAT using the new DAT heterozygous (DAT-HET) and homozygous mutant (DAT-KO) rat 
      models of hyperdopaminergia. We studied the impact of two breeding conditions in 
      spontaneous locomotor behavior of female rats. The classical colony, through 
      mating DAT-HET males x DAT-HET females (breeding HET-HET), was used. A second WT 
      colony was derived and maintained (breeding WT-WT). Additionally, a subgroup of 
      rats was bred through mating DAT-KO males x WT females (atypical HET, breeding 
      KO-WT). We studied the effects of genotype and its interaction with maternal care 
      (depending by breeding condition). HET-HET breeding led to reduced activity in 
      HET females compared to WT rats (from WT-WT breeding). However, HET females from 
      KO-WT breeding did not differ so much from WT rats (WT-WT breeding). The 
      maternal-care impact was then confirmed: HET mothers (breeding HET-HET) showed 
      reduced liking/grooming of pups and increased digging away from nest, compared to 
      WT mothers (breeding WT-WT). In their female offspring (HET, breeding HET-HET vs. 
      WT, breeding WT-WT), isolation plus wet bedding induced higher and more 
      persistent impact on activity of HET rats, even when the stressor was removed. 
      Our results highlight the importance of epigenetic factors (e.g., maternal care) 
      in responses to stress expressed by offspring at adulthood, quite independently 
      of genotype. DAT hypofunction could determinate vulnerability to stressful agents 
      via altered maternal care.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Mariano, Stefano
AU  - Mariano S
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanita 
      (I.S.S.), Rome, Italy.
AD  - Faculty of Psychology, Universita Telematica Internazionale Uninettuno 
      (U.T.I.U.), Rome, Italy.
FAU - Pardo, Marta
AU  - Pardo M
AUID- ORCID: 0000-0003-0808-1303
AD  - Department of Neurology, University of Miami Miller School of Medicine, Miami, 
      FL, USA.
FAU - Buccheri, Clelia
AU  - Buccheri C
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanita 
      (I.S.S.), Rome, Italy.
FAU - Illiano, Placido
AU  - Illiano P
AD  - Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, 
      Miami, FL, USA.
FAU - Adinolfi, Annalisa
AU  - Adinolfi A
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanita 
      (I.S.S.), Rome, Italy.
FAU - Lo Russo, Sara Lucia M
AU  - Lo Russo SLM
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanita 
      (I.S.S.), Rome, Italy.
FAU - Alleva, Enrico
AU  - Alleva E
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanita 
      (I.S.S.), Rome, Italy.
FAU - Carbone, Cristiana
AU  - Carbone C
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanita 
      (I.S.S.), Rome, Italy.
FAU - Adriani, Walter
AU  - Adriani W
AUID- ORCID: 0000-0002-0067-4430
AD  - Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanita 
      (I.S.S.), Rome, Italy.
AD  - Faculty of Psychology, Universita Telematica Internazionale Uninettuno 
      (U.T.I.U.), Rome, Italy.
LA  - eng
GR  - University of Miami/International
PT  - Journal Article
DEP - 20191010
PL  - United States
TA  - Dev Psychobiol
JT  - Developmental psychobiology
JID - 0164074
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Slc6a3 protein, rat)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Circadian Rhythm/*physiology
MH  - Disease Susceptibility
MH  - Dopamine Plasma Membrane Transport Proteins/*genetics
MH  - Epigenesis, Genetic/*physiology
MH  - Female
MH  - *Gene-Environment Interaction
MH  - Heterozygote
MH  - Locomotion/*physiology
MH  - Male
MH  - Maternal Behavior/*physiology
MH  - Rats, Transgenic
MH  - Rats, Wistar
MH  - Stress, Psychological/*physiopathology
OTO - NOTNLM
OT  - DAT heterozygous
OT  - circadian rhythm
OT  - maternal care
OT  - parent-of-origin effect
OT  - stress vulnerability
EDAT- 2019/10/11 06:00
MHDA- 2021/06/29 06:00
CRDT- 2019/10/11 06:00
PHST- 2019/05/03 00:00 [received]
PHST- 2019/08/29 00:00 [revised]
PHST- 2019/09/11 00:00 [accepted]
PHST- 2019/10/11 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2019/10/11 06:00 [entrez]
AID - 10.1002/dev.21927 [doi]
PST - ppublish
SO  - Dev Psychobiol. 2020 May;62(4):505-518. doi: 10.1002/dev.21927. Epub 2019 Oct 10.