PMID- 31599504 OWN - NLM STAT- MEDLINE DCOM- 20191022 LR - 20191022 IS - 1565-1088 (Print) VI - 21 IP - 10 DP - 2019 Oct TI - The Safety and Hemodynamic Effects of Pneumatic Sleeves in Patients with Severe Left Ventricular Dysfunction. PG - 649-652 AB - BACKGROUND: Pneumatic sleeves (PS) are often used during laparoscopic surgery and for prevention of deep vein thrombosis in patients who cannot receive anticoagulation treatment. There is very little information on the hemodynamic changes induced by PS and their effect on brain natriuretic peptide (BNP) in patients with severely reduced left ventricular ejection function (LVEF). OBJECTIVES: To determine the safety and hemodynamic changes induced by PS and their effects on brain natriuretic peptide (BNP). METHODS: This study comprised 14 patients classified as New York Heart Association (NYHA) II-III with severely reduced LVEF (< 40%). We activated the PS using two inflation pressures (50 or 80 mmHg, 7 patients in each group) at two cycles per minute for one hour. We measured echocardiography, hemodynamic parameters, and BNP levels in each patient prior to, during, and after the PS operation. RESULTS: The baseline LVEF did not change throughout the activation of PS (31 +/- 10% vs. 33 +/- 9%, P = 0.673). Following PS activation there was no significant difference in systolic or diastolic blood pressure, the pulse measurements, or central venous pressure. BNP levels did not change after PS activation (P = 0.074). CONCLUSIONS: The use of PS, with either low or high inflation pressures, is safe and has no detrimental effects on hemodynamic parameters or BNP levels in patients with severely reduced LVEF following clinical stabilization and optimal medical therapy. FAU - Moady, Gassan AU - Moady G AD - Department of Cardiology, Galilee Medical Center, Nahariya, Israel. FAU - Bickel, Amitai AU - Bickel A AD - Department of Surgery, Galilee Medical Center, Nahariya, Israel. AD - Azrieli Faculty of Medicine, Bar-Ilan University of the Galilee, Safed, Israel. FAU - Shturman, Alexander AU - Shturman A AD - Department of Cardiology, Galilee Medical Center, Nahariya, Israel. AD - Azrieli Faculty of Medicine, Bar-Ilan University of the Galilee, Safed, Israel. FAU - Khader, Muhammad AU - Khader M AD - Department of Cardiology, Galilee Medical Center, Nahariya, Israel. FAU - Atar, Shaul AU - Atar S AD - Department of Cardiology, Galilee Medical Center, Nahariya, Israel. AD - Azrieli Faculty of Medicine, Bar-Ilan University of the Galilee, Safed, Israel. LA - eng PT - Journal Article PL - Israel TA - Isr Med Assoc J JT - The Israel Medical Association journal : IMAJ JID - 100930740 RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM MH - Aged MH - Echocardiography MH - Female MH - Hemodynamics/*physiology MH - Humans MH - Intermittent Pneumatic Compression Devices/*adverse effects MH - Male MH - Natriuretic Peptide, Brain/blood MH - Ventricular Dysfunction, Left/blood/*physiopathology EDAT- 2019/10/11 06:00 MHDA- 2019/10/23 06:00 CRDT- 2019/10/11 06:00 PHST- 2019/10/11 06:00 [entrez] PHST- 2019/10/11 06:00 [pubmed] PHST- 2019/10/23 06:00 [medline] PST - ppublish SO - Isr Med Assoc J. 2019 Oct;21(10):649-652.