PMID- 31599972
OWN - NLM
STAT- MEDLINE
DCOM- 20200608
LR  - 20200608
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 59
IP  - 11
DP  - 2019 Nov
TI  - RBC and platelet transfusion support in the first 30 and 100 days after 
      haploidentical hematopoietic stem cell transplantation.
PG  - 3371-3385
LID - 10.1111/trf.15531 [doi]
AB  - BACKGROUND: The volume of haploidentical hematopoietic stem cell transplant 
      (haplo-HSCT) has increased dramatically in recent years. However, the associated 
      higher risk of delayed engraftment may increase patient transfusion requirements. 
      STUDY DESIGN AND METHODS: The post-HSCT RBC and platelet transfusions of 195 
      haplo-HSCT recipients were evaluated. Patient and transplant-related factors 
      potentially impacting the number of products transfused and time to transfusion 
      independence were assessed. RESULTS: Nearly all (98.4%) patients were transfused 
      in the first 30 days, and 59.2% were transfused between days 31 and 100. Among 
      the transfused patients, medians of 5 units (interquartile range [IQR] = 3-8) of 
      RBCs and 11 units (6-20) platelets were given in the first 30 days, and medians 
      of 3 units (IQR = 1-7) of RBCs and 6 units (2-18) of platelets were transfused 
      between days 31 and 100. Median times for achieving RBC and platelet transfusion 
      independence were 34 (95% CI: 28-40) and 25 (95% CI: 23-27) days, respectively. 
      Multivariable analyses showed that RBC transfusions in the 10 days before HSCT 
      were associated with significantly increased and sustained RBC and platelet 
      transfusion requirements. Major ABO incompatibility led to increased RBC 
      transfusions. Advanced disease was associated with increased transfusions during 
      the first 30 days, whereas GVHD increased platelet transfusions between days 31 
      and 100. Effects of age, sex, CD34+ cell dose, stem cell source, and conditioning 
      regimen were limited or insignificant. CONCLUSIONS: This study for the first time 
      provided quantitative transfusion data on a large cohort of haplo-HSCT recipients 
      and identified factors predictive of increased transfusions.
CI  - (c) 2019 AABB.
FAU - Yuan, Shan
AU  - Yuan S
AUID- ORCID: 0000-0002-9424-1790
AD  - Division of Transfusion Medicine, Department of Pathology, City of Hope National 
      Medical Center, Duarte, California.
FAU - Yang, Dongyun
AU  - Yang D
AD  - Department of Computational and Quantitative Medicine, City of Hope National 
      Medical Center, Duarte, California.
FAU - Nakamura, Ryotaro
AU  - Nakamura R
AD  - Department of Hematology and Hematopoietic Cell Transplantation, City of Hope 
      National Medical Center, Duarte, California.
FAU - Zhuang, Lefan
AU  - Zhuang L
AD  - Division of Transfusion Medicine, Department of Pathology, City of Hope National 
      Medical Center, Duarte, California.
FAU - Al Malki, Monzr M
AU  - Al Malki MM
AD  - Department of Hematology and Hematopoietic Cell Transplantation, City of Hope 
      National Medical Center, Duarte, California.
FAU - Wang, Shirong
AU  - Wang S
AD  - Division of Transfusion Medicine, Department of Pathology, City of Hope National 
      Medical Center, Duarte, California.
LA  - eng
PT  - Journal Article
DEP - 20191010
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (ABO Blood-Group System)
SB  - IM
MH  - ABO Blood-Group System/immunology
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Group Incompatibility
MH  - *Erythrocyte Transfusion
MH  - Female
MH  - Graft vs Host Disease/epidemiology/prevention & control
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Platelet Transfusion
MH  - Time Factors
MH  - *Transplantation, Haploidentical
MH  - Young Adult
EDAT- 2019/10/11 06:00
MHDA- 2020/06/09 06:00
CRDT- 2019/10/11 06:00
PHST- 2019/07/12 00:00 [received]
PHST- 2019/08/30 00:00 [revised]
PHST- 2019/08/30 00:00 [accepted]
PHST- 2019/10/11 06:00 [pubmed]
PHST- 2020/06/09 06:00 [medline]
PHST- 2019/10/11 06:00 [entrez]
AID - 10.1111/trf.15531 [doi]
PST - ppublish
SO  - Transfusion. 2019 Nov;59(11):3371-3385. doi: 10.1111/trf.15531. Epub 2019 Oct 10.