PMID- 31600692
OWN - NLM
STAT- MEDLINE
DCOM- 20200317
LR  - 20200317
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 76
DP  - 2019 Nov
TI  - BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous 
      cell carcinoma.
PG  - 105921
LID - S1567-5769(19)31407-9 [pii]
LID - 10.1016/j.intimp.2019.105921 [doi]
AB  - Drug resistance substantially limits the curative capability of chemotherapy in 
      head and neck cancers such as oral squamous cell carcinoma. Immunosuppression is 
      considered a potential cause of drug resistance. A key discovery in the past 
      decade is that chemotherapeutics can alter tumor cell immunogenicity via inducing 
      release of damage-associated molecular patterns (DAMPs), including 
      ecto-calreticulin (ecto-CALR), high mobility group box 1 (HMGB1) and ATP, causing 
      tumor cells to die in a manner known as bona fide immunogenic apoptosis or 
      immunogenic cell death (ICD). Intriguingly, JQ1 was found in this study to 
      exhibit therapeutic potential in tongue squamous cell carcinoma (TSCC) by 
      inducing ICD. JQ1 induced significant release of calreticulin (CALR), HMGB1 and 
      ATP from Cal27 and SCC7 cells in vitro. Immature dendritic cells (Im-DCs) 
      cocultured with JQ1-pretreated Cal27 cells exhibited significant upregulation of 
      mature markers on their surface and an increase in the secretion of cytokines. In 
      vivo experiments demonstrated that JQ1-pretreated dying SCC7 cells protected 
      immunocompetent mice from rechallenge of SCC7 cells. Intravenous injection of JQ1 
      efficiently reduced tumor growth and increased tumor-infiltration of 
      CD3(+)/CD8(+) T cells in C3H mice.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Wang, Miao
AU  - Wang M
AD  - Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of 
      Stomatology, Shandong University, Jinan, Shandong Province, China; Department of 
      Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, 
      Jinan, Shandong Province, China.
FAU - Zhao, Lu
AU  - Zhao L
AD  - Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of 
      Stomatology, Shandong University, Jinan, Shandong Province, China; .Department of 
      Stomatology, Binzhou People's Hospital, Binzhou, Shandong Province, China.
FAU - Tong, Dongdong
AU  - Tong D
AD  - Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of 
      Stomatology, Shandong University, Jinan, Shandong Province, China; Department of 
      Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, 
      Jinan, Shandong Province, China.
FAU - Yang, Linrui
AU  - Yang L
AD  - Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of 
      Stomatology, Shandong University, Jinan, Shandong Province, China; Department of 
      Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, 
      Jinan, Shandong Province, China.
FAU - Zhu, Hongjie
AU  - Zhu H
AD  - Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of 
      Stomatology, Shandong University, Jinan, Shandong Province, China; Department of 
      Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, 
      Jinan, Shandong Province, China.
FAU - Li, Qing
AU  - Li Q
AD  - Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of 
      Stomatology, Shandong University, Jinan, Shandong Province, China; Department of 
      Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, 
      Jinan, Shandong Province, China.
FAU - Zhang, Fenghe
AU  - Zhang F
AD  - Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of 
      Stomatology, Shandong University, Jinan, Shandong Province, China; Department of 
      Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, 
      Jinan, Shandong Province, China. Electronic address: zfengh@sdu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191007
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 ((+)-JQ1 compound)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Azepines)
RN  - 0 (BRD4 protein, human)
RN  - 0 (Brd4 protein, mouse)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Cytokines)
RN  - 0 (HMGB1 Protein)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Triazoles)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology/*therapeutic use
MH  - Apoptosis/drug effects
MH  - Azepines/pharmacology/*therapeutic use
MH  - Carcinoma, Squamous Cell/*drug therapy/immunology/pathology
MH  - Cell Cycle Proteins/*antagonists & inhibitors/genetics
MH  - Cell Death/drug effects
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Coculture Techniques
MH  - Cytokines/immunology
MH  - Dendritic Cells/drug effects/immunology
MH  - Female
MH  - HMGB1 Protein/metabolism
MH  - Humans
MH  - Mice, Inbred C3H
MH  - Mice, Nude
MH  - Nuclear Proteins/*antagonists & inhibitors/genetics
MH  - T-Lymphocytes/drug effects/immunology
MH  - Tongue Neoplasms/*drug therapy/immunology/pathology
MH  - Transcription Factors/*antagonists & inhibitors/genetics
MH  - Triazoles/pharmacology/*therapeutic use
OTO - NOTNLM
OT  - BET inhibitor
OT  - Immunogenic cell death
OT  - JQ1
OT  - Tongue squamous cell carcinoma
OT  - p-eIF2a
EDAT- 2019/10/11 06:00
MHDA- 2020/03/18 06:00
CRDT- 2019/10/11 06:00
PHST- 2019/06/29 00:00 [received]
PHST- 2019/09/15 00:00 [revised]
PHST- 2019/09/15 00:00 [accepted]
PHST- 2019/10/11 06:00 [pubmed]
PHST- 2020/03/18 06:00 [medline]
PHST- 2019/10/11 06:00 [entrez]
AID - S1567-5769(19)31407-9 [pii]
AID - 10.1016/j.intimp.2019.105921 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2019 Nov;76:105921. doi: 10.1016/j.intimp.2019.105921. Epub 
      2019 Oct 7.