PMID- 31601203
OWN - NLM
STAT- MEDLINE
DCOM- 20200312
LR  - 20200312
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Oct 11
TI  - Prevalence of cardiovascular risk factors in non-menopausal and postmenopausal 
      inpatients with type 2 diabetes mellitus in China.
PG  - 98
LID - 10.1186/s12902-019-0427-7 [doi]
LID - 98
AB  - BACKGROUND: To investigate the prevalence of cardiovascular disease (CVD) risk 
      factors and assess the 10-year risk of CVD in non-menopausal and postmenopausal 
      women with type 2 diabetes mellitus (T2DM). METHODS: A total of 569 patients with 
      T2DM at a Chinese tertiary hospital were investigated using the Framingham Risk 
      Score (FRS). We evaluated the 10-year risk of CVD, clinical and menopause 
      characteristics in all subjects. RESULTS: Among the 569 diabetic patients, the 
      incidence of smoking, dyslipidemia, hypertension, overweight or obesity, and 
      nonalcoholic fatty liver disease (NAFLD) was 0.7, 36.2, 38.1 56.6 and 58.2%, 
      respectively. The usage rate of hypoglycemic agents, antihypertensive agents, 
      lipid modulators and antithrombotic drugs was 88.6, 78.3, 50.0 and 27.1%, 
      respectively. However, only 1.2% of inpatients achieved the three target goals 
      for the control of blood glucose (HbA(1c) < 7%), blood pressure (systolic blood 
      pressure < 130 mmHg, diastolic blood pressure < 80 mmHg), and blood lipids (total 
      cholesterol < 174 mg/dL). The 10-year risk of CVD was (1.6 +/- 1.5%) and tended to 
      increase along with age (F = 27.726, P <  0.001). For all subjects (n = 569), 
      multiple linear regression analysis showed that menopause (beta = 0.275, 
      P <  0.001), low-density lipoprotein cholesterol (LDL-C) (beta = 0.212, P <  0.001), 
      fasting plasma glucose (FPG) (beta = 0.093, P = 0.018) and waist-to-hip-ratio 
      (beta = - 0.078, P = 0.047) were risk factors of 10-year risk of CVD, which may 
      explain the variance of 14.3%. In the postmenopausal group (n = 397), LDL-C 
      (beta = 0.227, P <  0.001), FPG (beta = 0.139, P = 0.003) and time since menopause 
      (beta = 0.230, P <  0.001) were found to be associated with CVD, which may explain 
      the variance of 14.6%. CONCLUSION: The incidence of dyslipidmia, hypertension, 
      overweight or obesity and NAFLD is high. The level of control of blood glucose, 
      blood pressure, and blood lipids was found to be extremely low and the treatment 
      status was not ideal. Besides menopause, LDL-C, FPG and time since menopause were 
      found to be independent risk factors for the 10-year risk of CVD. Therefore, it 
      is necessary to focus on comprehensive control of multiple risk factors, such as 
      plasma glucose, blood pressure and serum lipid.
FAU - Zhou, Huanhuan
AU  - Zhou H
AD  - The First People's Hospital of Changzhou, 185# Juqian Road, Changzhou, 213000, 
      Jiangsu Province, China.
FAU - Zhang, Chenghuan
AU  - Zhang C
AD  - The First People's Hospital of Changzhou, 185# Juqian Road, Changzhou, 213000, 
      Jiangsu Province, China.
FAU - Ni, Jingyu
AU  - Ni J
AD  - The First People's Hospital of Changzhou, 185# Juqian Road, Changzhou, 213000, 
      Jiangsu Province, China.
FAU - Han, Xiaoyun
AU  - Han X
AUID- ORCID: 0000-0002-6257-8540
AD  - The First People's Hospital of Changzhou, 185# Juqian Road, Changzhou, 213000, 
      Jiangsu Province, China. lanao163@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20191011
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Biomarkers/analysis
MH  - Cardiovascular Diseases/*epidemiology/*etiology/metabolism/pathology
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - *Postmenopause
MH  - *Premenopause
MH  - Prevalence
MH  - Prognosis
MH  - Risk Factors
PMC - PMC6787985
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Diabetes mellitus
OT  - Framingham risk score
OT  - Menopause
OT  - Type 2
COIS- The authors declare that they have no competing interests.
EDAT- 2019/10/12 06:00
MHDA- 2020/03/13 06:00
PMCR- 2019/10/11
CRDT- 2019/10/12 06:00
PHST- 2019/04/29 00:00 [received]
PHST- 2019/09/13 00:00 [accepted]
PHST- 2019/10/12 06:00 [entrez]
PHST- 2019/10/12 06:00 [pubmed]
PHST- 2020/03/13 06:00 [medline]
PHST- 2019/10/11 00:00 [pmc-release]
AID - 10.1186/s12902-019-0427-7 [pii]
AID - 427 [pii]
AID - 10.1186/s12902-019-0427-7 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2019 Oct 11;19(1):98. doi: 10.1186/s12902-019-0427-7.