PMID- 31601346
OWN - NLM
STAT- MEDLINE
DCOM- 20191114
LR  - 20200108
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 48
IP  - 4
DP  - 2019 Jul
TI  - [Effects of methylenetetrahydrofolate reductase gene polymorphism and long-term 
      exposure to organophosphorus pesticides on type 2 diabetes mellitus].
PG  - 621-627
AB  - OBJECTIVE: To investigate the effect of the interaction between 
      methylenetetrahydrofolate reductase(MTHFR) genotype and allele and long-term 
      exposure to organophosphorus pesticides on the development of type 2 diabetes 
      mellitus(T2 DM). METHODS: A total of 209 cases of T2 DM(case group) and 216 cases 
      without T2 DM(control group) were selected as subjects. The polymorphism of 
      MTHFR(rs1801133) was detected by TaqMan probe technique. The relationship between 
      genes, long-term exposure to organophosphorus pesticides and T2 DM was analyzed 
      by Logistic regression. The interaction between gene and long-term exposure to 
      organophosphorus pesticides was discussed by crossover analysis and generalized 
      multifactor dimensionality reduction. RESULTS: BMI⇿4, residence in countryside, 
      long-term exposure to organophosphorus pesticides and family history of diabetes 
      mellitus were risk factors for T2 DM. MTHFR genotype distribution conformed to 
      Hardy-Weinberg equilibrium(P>0. 05). There was no significant difference in 
      genotype distribution frequency between case group and control group. The risk of 
      T2 DM in individuals with CT and TT genotypes was 1. 667 times higher than that 
      of CC genotypes after adjusting the covariates at rs1801133 locus in the dominant 
      model(95%CI 1. 057-2. 627, P=0. 028). It suggested that the samples of allele T 
      had a increased risk of T2 DM compared with those without allele T. The above 
      models still had statistical significance(P<0. 05) after adjusting the 
      covariates. Forth, crossover analysis showed that the gene MTHFR(rs1801133) and 
      long-term exposure to organophosphorus pesticides had multiplication interaction. 
      The interaction between gene MTHFR(rs1801133) and long-term exposure to 
      organophosphorus pesticides may play a role in the pathogenesis of T2 DM. 
      Generalized multifactor dimensionality reduction(GMDR)analysis showed that the 
      interaction model of MTHFR(rs1801133) gene and family history of diabetes 
      mellitus was the best model. CONCLUSION: MTHFR(rs1801133) gene CT and TT genotype 
      may be risk factors for T2 DM. The interaction between genetic polymorphism and 
      environmental factors increases the risk of T2 DM.
FAU - Dong, Yuwei
AU  - Dong Y
AD  - College of Food Engineering, Xuzhou University of Technology, Xuzhou 221018, 
      China.
FAU - Li, Wen
AU  - Li W
AD  - College of Food Engineering, Xuzhou University of Technology, Xuzhou 221018, 
      China.
FAU - Wang, Tao
AU  - Wang T
AD  - College of Food Engineering, Xuzhou University of Technology, Xuzhou 221018, 
      China.
FAU - Miao, Jingzhi
AU  - Miao J
AD  - College of Food Engineering, Xuzhou University of Technology, Xuzhou 221018, 
      China.
FAU - Li, Tongxiang
AU  - Li T
AD  - College of Food Engineering, Xuzhou University of Technology, Xuzhou 221018, 
      China.
FAU - Zhou, Yifu
AU  - Zhou Y
AD  - Xuzhou United Gene Company Limited, Xuzhou 221000, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Pesticides)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Organophosphorus Compounds/*toxicity
MH  - Pesticides/*toxicity
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - interaction effect
OT  - methylenetetrahydrofolate reductase
OT  - organophosphorus pesticides
OT  - polymorphism
OT  - type 2 diabetes mellitus
EDAT- 2019/10/12 06:00
MHDA- 2019/11/15 06:00
CRDT- 2019/10/12 06:00
PHST- 2019/10/12 06:00 [entrez]
PHST- 2019/10/12 06:00 [pubmed]
PHST- 2019/11/15 06:00 [medline]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2019 Jul;48(4):621-627.