PMID- 31604366 OWN - NLM STAT- MEDLINE DCOM- 20201207 LR - 20201214 IS - 1399-5618 (Electronic) IS - 1398-5647 (Linking) VI - 22 IP - 3 DP - 2020 May TI - Investigating the neural basis of cognitive control dysfunction in mood disorders. PG - 286-295 LID - 10.1111/bdi.12844 [doi] AB - OBJECTIVES: Dysfunction of cognitive control is a feature of both bipolar disorder (BP) and major depression (MDD) and persists through to remission. However, it is unknown whether these disorders are characterized by common or distinct disruptions of cognitive control function and its neural basis. We investigated this gap in knowledge in asymptomatic BP and MDD participants, interpreted within a framework of normative function. METHODS: Participants underwent fMRI scans engaging cognitive control through a working memory task and completed a cognitive battery evaluating performance across multiple subdomains of cognitive control, including attention, impulsivity, processing speed, executive function, and memory. Analysis was performed in two stages: (i) cognitive control-related brain activation and deactivation were correlated with cognitive control performance in 115 healthy controls (HCs), then, (ii) significantly correlated regions from (i) were compared between 25 asymptomatic BP, 25 remitted MDD, and with 25 different HCs, matched for age and gender. RESULTS: Impulsivity and executive function performance were significantly worse in BP compared to both MDD and HCs. Both BP and MDD had significantly poorer memory performance compared to HCs. Greater deactivation of the medial prefrontal cortex (MPFC) during the fMRI task was associated with better executive function in healthy controls. Significantly less deactivation in this region was present in both BP and MDD compared to HCs. CONCLUSIONS: Failure to deactivate the MPFC, a key region of the default mode network, during working memory processing is a shared neural feature present in both bipolar and major depression and could be a source of common cognitive dysfunction. CI - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Breukelaar, Isabella A AU - Breukelaar IA AUID- ORCID: 0000-0002-6241-5274 AD - Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia. FAU - Erlinger, May AU - Erlinger M AD - Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia. FAU - Harris, Anthony AU - Harris A AD - Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia. AD - Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, Australia. FAU - Boyce, Philip AU - Boyce P AD - Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, Australia. FAU - Hazell, Philip AU - Hazell P AD - Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, Australia. FAU - Grieve, Stuart M AU - Grieve SM AD - Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia. AD - Sydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre and Sydney Medical School, University of Sydney, Camperdown, NSW, Australia. AD - Department of Radiology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia. FAU - Antees, Cassandra AU - Antees C AD - Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia. FAU - Foster, Sheryl AU - Foster S AD - Department of Radiology, Westmead Hospital, Westmead, NSW, Australia. AD - The Discipline of Medical Radiation Sciences, Faculty of Health Science, The University of Sydney, Lidcombe, NSW, Australia. FAU - Gomes, Lavier AU - Gomes L AD - Department of Radiology, Westmead Hospital, Westmead, NSW, Australia. FAU - Williams, Leanne M AU - Williams LM AD - Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. AD - Palo Alto VA, MIRECC, Palo Alto, CA, USA. FAU - Malhi, Gin S AU - Malhi GS AD - Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, Australia. AD - CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Saint Leonards, NSW, Australia. FAU - Korgaonkar, Mayuresh S AU - Korgaonkar MS AD - Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia. AD - Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, Australia. LA - eng GR - Parker Hughes Bequest/International GR - Heart Research Institute/International GR - APP1073041/National Health and Medical Research Council/International GR - APP1087560/National Health and Medical Research Council/International GR - APP1090148/National Health and Medical Research Council/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191022 PL - Denmark TA - Bipolar Disord JT - Bipolar disorders JID - 100883596 SB - IM MH - Adult MH - Attention/physiology MH - Bipolar Disorder/*physiopathology MH - Cognition/physiology MH - Cognitive Dysfunction/*physiopathology MH - Depressive Disorder, Major/*physiopathology MH - Executive Function/physiology MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Memory, Short-Term/physiology MH - Prefrontal Cortex/physiopathology MH - Young Adult OTO - NOTNLM OT - bipolar disorders OT - cognitive control OT - depression OT - euthymic OT - fMRI activation EDAT- 2019/10/12 06:00 MHDA- 2020/12/15 06:00 CRDT- 2019/10/12 06:00 PHST- 2019/10/12 06:00 [pubmed] PHST- 2020/12/15 06:00 [medline] PHST- 2019/10/12 06:00 [entrez] AID - 10.1111/bdi.12844 [doi] PST - ppublish SO - Bipolar Disord. 2020 May;22(3):286-295. doi: 10.1111/bdi.12844. Epub 2019 Oct 22.