PMID- 31605274
OWN - NLM
STAT- MEDLINE
DCOM- 20220208
LR  - 20240130
IS  - 1532-6551 (Electronic)
IS  - 1071-3581 (Linking)
VI  - 28
IP  - 4
DP  - 2021 Aug
TI  - The rate of myocardial perfusion recovery after steroid therapy and its 
      implication for cardiac events in cardiac sarcoidosis and primarily preserved 
      left ventricular ejection fraction.
PG  - 1745-1756
LID - 10.1007/s12350-019-01916-4 [doi]
AB  - BACKGROUND: Sarcoidosis is a multisystemic disorder of unknown cause 
      characterized by immune granuloma formation in the involved organs. Few studies 
      have reported on the myocardial perfusion changes by immunosuppression therapy in 
      cardiac sarcoidosis (CS). Additionally, the relationship between myocardial 
      perfusion changes and prognosis is unknown. Therefore, this study aimed to 
      clarify myocardial perfusion recovery after steroid therapy and its prognostic 
      value for major adverse cardiac events (MACE) in patients with CS. METHODS AND 
      RESULTS: Thirty-eight consecutive patients with CS median age, 63 [interquartile 
      range (IQR) 51-68] years; 10 men underwent both (18)F-fluorodeoxyglucose 
      positron emission tomography/computed tomography (CT) and 
      electrocardiography-gated single-photon emission CT (SPECT) pre- and post-steroid 
      therapy. Patients with improved or preserved myocardial perfusion after 
      post-therapy were defined as the recovery group and those with worsened 
      myocardial perfusion as the non-recovery group. Twenty-six patients (68%) were 
      categorized as the recovery group. MACE occurred in eight patients. The 
      Kaplan-Meier curves revealed a significantly higher rate of MACE in the 
      non-recovery group (17.4%/y vs 2.9%/y, P = 0.007). CONCLUSIONS: Myocardial 
      perfusion was recovered by steroid therapy in 61% and preserved in 8% of 
      patients. Myocardial perfusion recovery after steroid therapy was significantly 
      associated with a low incidence of MACE.
CI  - (c) 2019. American Society of Nuclear Cardiology.
FAU - Koyanagawa, Kazuhiro
AU  - Koyanagawa K
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, 
      Japan.
FAU - Naya, Masanao
AU  - Naya M
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, 
      Japan. naya@med.hokudai.ac.jp.
FAU - Aikawa, Tadao
AU  - Aikawa T
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, 
      Japan.
FAU - Manabe, Osamu
AU  - Manabe O
AD  - Department of Diagnostic and Interventional Radiology, Hokkaido University 
      Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, 060-8648, Japan.
FAU - Furuya, Sho
AU  - Furuya S
AD  - Department of Diagnostic and Interventional Radiology, Hokkaido University 
      Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, 060-8648, Japan.
FAU - Kuzume, Masato
AU  - Kuzume M
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, 
      Japan.
FAU - Oyama-Manabe, Noriko
AU  - Oyama-Manabe N
AD  - Department of Diagnostic and Interventional Radiology, Hokkaido University 
      Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, 060-8648, Japan.
FAU - Ohira, Hiroshi
AU  - Ohira H
AD  - First Department of Medicine, Hokkaido University Hospital, Kita-14, Nishi-5, 
      Kita-ku, Sapporo, 060-8648, Japan.
FAU - Tsujino, Ichizo
AU  - Tsujino I
AD  - First Department of Medicine, Hokkaido University Hospital, Kita-14, Nishi-5, 
      Kita-ku, Sapporo, 060-8648, Japan.
FAU - Anzai, Toshihisa
AU  - Anzai T
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20191011
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
RN  - 0 (Glucocorticoids)
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Aged
MH  - Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography
MH  - Coronary Circulation/*physiology
MH  - Electrocardiography
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Glucocorticoids/*therapeutic use
MH  - Heart Diseases/diagnostic imaging/*drug therapy/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Perfusion Imaging
MH  - Positron Emission Tomography Computed Tomography
MH  - Prednisolone/*therapeutic use
MH  - Radiopharmaceuticals
MH  - Recovery of Function/physiology
MH  - Retrospective Studies
MH  - Sarcoidosis/diagnostic imaging/*drug therapy/physiopathology
MH  - Stroke Volume/physiology
EDAT- 2019/10/13 06:00
MHDA- 2022/02/09 06:00
CRDT- 2019/10/13 06:00
PHST- 2019/07/22 00:00 [received]
PHST- 2019/09/23 00:00 [accepted]
PHST- 2019/09/01 00:00 [revised]
PHST- 2019/10/13 06:00 [pubmed]
PHST- 2022/02/09 06:00 [medline]
PHST- 2019/10/13 06:00 [entrez]
AID - S1071-3581(23)00987-X [pii]
AID - 10.1007/s12350-019-01916-4 [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2021 Aug;28(4):1745-1756. doi: 10.1007/s12350-019-01916-4. Epub 
      2019 Oct 11.