PMID- 31605579
OWN - NLM
STAT- MEDLINE
DCOM- 20200511
LR  - 20200511
IS  - 2191-0251 (Electronic)
IS  - 0334-018X (Linking)
VI  - 32
IP  - 12
DP  - 2019 Dec 18
TI  - Near final adult height, and body mass index in overweight/obese and 
      normal-weight children with idiopathic central precocious puberty and treated 
      with gonadotropin-releasing hormone analogs.
PG  - 1369-1375
LID - 10.1515/jpem-2019-0136 [doi]
AB  - Background The standard treatment of central precocious puberty (CPP) is 
      gonadotropin-releasing hormone analogues (GnRHa). It is a concern that children 
      treated with GnRHa are at risk of developing obesity which could impair the 
      treatment outcomes. This study aimed to investigate the effect of GnRHa on body 
      mass index (BMI) standard deviation score (SDS), and the influence of BMI status 
      on treatment outcomes in children with idiopathic CPP (iCPP). Methods A 
      retrospective cohort study in children with iCPP who completed GnRHa treatment 
      and had attained near final adult height (NFAH) was conducted. Children with a 
      history of disease or drug ingestion which could affect their BMI were excluded. 
      BMI, BMI SDS, height (Ht), Ht SDS, predicted adult height (PAH), and NFAH were 
      compared at baseline, 1 and 2 years during treatment, and at NFAH according to 
      the baseline BMI status; normal weight and overweight/obesity. Results 
      Fifty-eight children with iCPP treated with GnRHa were enrolled. The BMI SDS was 
      significantly increased at 1 and 2 years during treatment in the overweight/obese 
      group and at 1 year during treatment in the normal-weight group. However, at NFAH 
      (2 years after treatment discontinuation), the BMI SDS was not statistically 
      different from baseline in both groups. Ht gain, change in Ht SDS and BMI SDS 
      were not statistically different from the baseline in both groups. Conclusions 
      GnRHa results in a transient increase in BMI SDS during treatment and returned to 
      baseline after treatment cessation. The benefit of GnRHa treatment on final Ht 
      improvement is similar between overweight/obese and normal-weight patients.
FAU - Sinthuprasith, Pattharaphorn
AU  - Sinthuprasith P
AD  - Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, 
      Thailand.
FAU - Dejkhamron, Prapai
AU  - Dejkhamron P
AD  - Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 
      50200, Thailand, Phone: +66-53-93-6462, Fax: +66-53-93-6461.
FAU - Wejaphikul, Karn
AU  - Wejaphikul K
AD  - Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, 
      Thailand.
FAU - Unachak, Kevalee
AU  - Unachak K
AD  - Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, 
      Thailand.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
SB  - IM
MH  - Adult
MH  - *Body Height
MH  - *Body Weight
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Gonadotropin-Releasing Hormone/*administration & dosage/analogs & derivatives
MH  - Humans
MH  - Male
MH  - Obesity/*physiopathology
MH  - Overweight/*physiopathology
MH  - Prevalence
MH  - Puberty, Precocious/*drug therapy/epidemiology/pathology
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - BMI
OT  - GnRHa
OT  - central precocious puberty
EDAT- 2019/10/13 06:00
MHDA- 2020/05/12 06:00
CRDT- 2019/10/13 06:00
PHST- 2019/03/24 00:00 [received]
PHST- 2019/08/28 00:00 [accepted]
PHST- 2019/10/13 06:00 [pubmed]
PHST- 2020/05/12 06:00 [medline]
PHST- 2019/10/13 06:00 [entrez]
AID - /j/jpem.ahead-of-print/jpem-2019-0136/jpem-2019-0136.xml [pii]
AID - 10.1515/jpem-2019-0136 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2019 Dec 18;32(12):1369-1375. doi: 
      10.1515/jpem-2019-0136.