PMID- 31606023
OWN - NLM
STAT- MEDLINE
DCOM- 20200402
LR  - 20200402
IS  - 2448-9190 (Electronic)
IS  - 0002-5151 (Linking)
VI  - 66
IP  - 3
DP  - 2019 Jul-Sep
TI  - Delayed aminopenicillin reaction associated to human herpes virus 6 infection 
      mimicking DRESS syndrome.
PG  - 375-378
LID - 10.29262/ram.v66i3.540 [doi]
AB  - BACKGROUND: DRESS syndrome (rash with eosinophilia and systemic symptoms) is an 
      uncommon and severe drug-induced reaction. CLINICAL CASE: An 8-year-old boy was 
      diagnosed with tonsillopharyngitis, and treatment with amoxicillin was started. 
      One day later, he presented bilateral malar rash which evolved to generalized 
      erythroderma in two days. He was referred to the emergency room and then he was 
      discharged after the treatment with amoxicillin was discontinued. Five days 
      later, he still had fever, progressive facial and acral edema, and ecchymotic 
      lesions. The laboratory studies showed 6220 leukocytes/mm3 (970 eosinophils/mm3). 
      The pharyngeal culture tested positive to human herpesvirus 6 (HHV-6). The fever, 
      rash and edema disappeared with supportive measures. Based on the results of the 
      allergy tests, a diagnosis of delayed reaction to aminopenicillin associated to 
      HHV-6 mimicking DRESS syndrome was made, with the recommendation to avoid 
      penicillin antibiotics. CONCLUSION: The diagnosis of delayed reactions to 
      aminopenicillin and DRESS syndrome requires a high index of suspicion in order to 
      promptly withdraw the offending medication and to avoid delays in the diagnosis.
FAU - Miguez-Martin, Laura
AU  - Miguez-Martin L
AD  - Hospital Universitario de Cabuenes, Servicio de Pediatria, Gijon, Spain. 
      lmiguez90@gmail.com.
FAU - Higelmo-Gomez, Helena
AU  - Higelmo-Gomez H
FAU - Gomez-Farpon, Angela
AU  - Gomez-Farpon A
FAU - Alvarez-Caro, Francisco
AU  - Alvarez-Caro F
LA  - eng
PT  - Case Reports
PT  - Journal Article
TT  - Reaccion tardia a aminopenicilina asociada con infeccion por el virus del herpes 
      humano 6 que simula sindrome DRESS.
PL  - Mexico
TA  - Rev Alerg Mex
JT  - Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
JID - 9438824
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Penicillins)
SB  - IM
MH  - Anti-Bacterial Agents/*adverse effects
MH  - Child
MH  - Drug Hypersensitivity Syndrome/*diagnosis/*etiology
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Male
MH  - Penicillins/*adverse effects
MH  - Roseolovirus Infections/diagnosis
MH  - Time Factors
OTO - NOTNLM
OT  - Amoxicillin
OT  - DRESS syndrome
OT  - Eosinophilia
OT  - Human herpesvirus 6
EDAT- 2019/10/14 06:00
MHDA- 2020/04/03 06:00
CRDT- 2019/10/14 06:00
PHST- 2019/10/14 06:00 [entrez]
PHST- 2019/10/14 06:00 [pubmed]
PHST- 2020/04/03 06:00 [medline]
AID - 10.29262/ram.v66i3.540 [doi]
PST - ppublish
SO  - Rev Alerg Mex. 2019 Jul-Sep;66(3):375-378. doi: 10.29262/ram.v66i3.540.