PMID- 3160633
OWN - NLM
STAT- MEDLINE
DCOM- 19850823
LR  - 20190824
IS  - 0306-3623 (Print)
IS  - 0306-3623 (Linking)
VI  - 16
IP  - 3
DP  - 1985
TI  - Beta-endorphin: a common factor in the antihypertensive action of clonidine-type 
      imidazolines in spontaneously hypertensive rats.
PG  - 287-90
AB  - The hypotensive action of two novel imidazolinic alpha-adrenergic agonists 
      (ICI-106270 and UK-14304) with similar pharmacological properties to clonidine 
      was shown in spontaneously hypertensive (SH) rats. The antihypertensive effect of 
      the clonidine-type agents was prevented by either peripheral administration of 
      the opiate antagonist naloxone or by intracerebroventricular (i.c.v.) injection 
      with a specific antibody against human beta-endorphin (BEN). A dose-response 
      relationship was found for the hypotensive effect of i.c.v. given BEN in SH rats, 
      the low blood pressure being significantly reversed by further treatment with 
      either naloxone or anti-beta h-endorphin. These data confirm and extend the 
      notion of a BEN mediation in the antihypertensive action of clonidine-type 
      alpha-adrenergic agonists in SH rats.
FAU - Naranjo, J R
AU  - Naranjo JR
FAU - Fernandez-Roman, M
AU  - Fernandez-Roman M
FAU - Urdin, M C
AU  - Urdin MC
FAU - Fuentes, J A
AU  - Fuentes JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Gen Pharmacol
JT  - General pharmacology
JID - 7602417
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Endorphins)
RN  - 0 (Imidazoles)
RN  - 0 (Quinoxalines)
RN  - 4S9CL2DY2H (Brimonidine Tartrate)
RN  - 60617-12-1 (beta-Endorphin)
RN  - 67249-51-8 (ICI 106270)
RN  - MN3L5RMN02 (Clonidine)
SB  - IM
MH  - Animals
MH  - Antihypertensive Agents/*pharmacology
MH  - Blood Pressure/drug effects
MH  - Brimonidine Tartrate
MH  - Clonidine/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Endorphins/*physiology
MH  - Hypertension/*physiopathology
MH  - Imidazoles/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Quinoxalines/pharmacology
MH  - Rats
MH  - beta-Endorphin
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 0306-3623(85)90086-2 [pii]
AID - 10.1016/0306-3623(85)90086-2 [doi]
PST - ppublish
SO  - Gen Pharmacol. 1985;16(3):287-90. doi: 10.1016/0306-3623(85)90086-2.