PMID- 31606355 OWN - NLM STAT- MEDLINE DCOM- 20200630 LR - 20200630 IS - 1872-7492 (Electronic) IS - 0168-1702 (Linking) VI - 274 DP - 2019 Dec TI - Toward peste des petits virus (PPRV) eradication: Diagnostic approaches, novel vaccines, and control strategies. PG - 197774 LID - S0168-1702(19)30495-2 [pii] LID - 10.1016/j.virusres.2019.197774 [doi] AB - Peste des petits ruminants (PPR) is an acute transboundary infectious viral disease affecting domestic and wild small ruminants' species besides camels reared in Africa, Asia and the Middle East. The virus is a serious paramount challenge to the sustainable agriculture advancement in the developing world. The disease outbreak was also detected for the first time in the European Union namely in Bulgaria at 2018. Therefore, the disease has lately been aimed for eradication with the purpose of worldwide clearance by 2030. Radically, the vaccines needed for effectively accomplishing this aim are presently convenient; however, the availableness of innovative modern vaccines to fulfill the desideratum for Differentiating between Infected and Vaccinated Animals (DIVA) may mitigate time spent and financial disbursement of serological monitoring and surveillance in the advanced levels for any disease obliteration campaign. We here highlight what is at the present time well-known about the virus and the different available diagnostic tools. Further, we interject on current updates and insights on several novel vaccines and on the possible current and prospective strategies to be applied for disease control. CI - Copyright (c) 2019 Elsevier B.V. All rights reserved. FAU - Kamel, Mohamed AU - Kamel M AD - Faculty of Veterinary Medicine, Department of Medicine and Infectious Diseases, Cairo University, Giza, Egypt. Electronic address: m_salah@staff.cu.edu.eg. FAU - El-Sayed, Amr AU - El-Sayed A AD - Faculty of Veterinary Medicine, Department of Medicine and Infectious Diseases, Cairo University, Giza, Egypt. LA - eng PT - Journal Article PT - Review DEP - 20191010 PL - Netherlands TA - Virus Res JT - Virus research JID - 8410979 RN - 0 (Vaccines, Attenuated) RN - 0 (Viral Vaccines) SB - IM MH - Animals MH - Clinical Laboratory Techniques/veterinary MH - *Disease Eradication MH - Genome, Viral MH - Peste-des-Petits-Ruminants/*diagnosis/epidemiology/*prevention & control MH - *Peste-des-petits-ruminants virus/classification/immunology/isolation & purification/physiology MH - Vaccination/veterinary MH - Vaccines, Attenuated/administration & dosage/classification MH - Viral Vaccines/administration & dosage/classification OTO - NOTNLM OT - DIVA OT - Live attenuated vaccine OT - Live vector vaccine OT - PPR OT - PPR control OT - PPR diagnosis OT - PPRV OT - Subunit vaccines EDAT- 2019/10/14 06:00 MHDA- 2020/07/01 06:00 CRDT- 2019/10/14 06:00 PHST- 2019/07/15 00:00 [received] PHST- 2019/09/16 00:00 [revised] PHST- 2019/10/04 00:00 [accepted] PHST- 2019/10/14 06:00 [pubmed] PHST- 2020/07/01 06:00 [medline] PHST- 2019/10/14 06:00 [entrez] AID - S0168-1702(19)30495-2 [pii] AID - 10.1016/j.virusres.2019.197774 [doi] PST - ppublish SO - Virus Res. 2019 Dec;274:197774. doi: 10.1016/j.virusres.2019.197774. Epub 2019 Oct 10.