PMID- 31606740
OWN - NLM
STAT- MEDLINE
DCOM- 20210414
LR  - 20210414
IS  - 1550-9109 (Electronic)
IS  - 0161-8105 (Linking)
VI  - 43
IP  - 3
DP  - 2020 Mar 12
TI  - HLA and sleep parameter associations in post-H1N1 narcolepsy type 1 patients and 
      first-degree relatives.
LID - zsz239 [pii]
LID - 10.1093/sleep/zsz239 [doi]
AB  - STUDY OBJECTIVES: To explore HLA (human leukocyte antigen) in post-H1N1 
      narcolepsy type 1 patients (NT1), first-degree relatives and healthy controls, 
      and assess HLA associations with clinical and sleep parameters in patients and 
      first-degree relatives. METHODS: Ninety post-H1N1 NT1 patients and 202 of their 
      first-degree relatives were HLA-genotyped (next generation sequencing) and 
      phenotyped (semistructured interviews, Stanford Sleep Questionnaire, 
      polysomnography, and multiple sleep latency test). HLA allele distributions were 
      compared between DQB1*06:02-heterozygous individuals (77 patients, 59 parents, 
      1230 controls). A subsample (74 patients, 114 relatives) was investigated for 
      associations between HLA-loci and continuous sleep variables using logistic 
      regression. Identified candidate HLA-loci were explored for HLA allele 
      associations with hypnagogic hallucinations and sleep paralysis in 90 patients, 
      and patient allele findings were checked for similar associations in 202 
      relatives. RESULTS: DQB1*06:02 heterozygous post-H1N1 NT1 patients (84.4% 
      H1N1-vaccinated) showed several significant HLA associations similar to those 
      reported previously in samples of mainly sporadic NT1, i.e. DQB1*03:01, 
      DRB1*04:01, DRB1*04:02, DRB1*04:07, DRB1*11:04, A*25:01, B*35:03, and B*51:01, 
      and novel associations, i.e. B*14:02, C*01:02, and C*07:01. Parents HLA alleles 
      did not deviate significantly from controls. The HLA-C locus was associated with 
      sleep parameters in patients and relatives. In patients C*02:02 seems to be 
      associated with protective effects against sleep paralysis and hypnagogic 
      hallucinations. CONCLUSIONS: Our findings of similar risk/protective HLA-alleles 
      in post-H1N1 as in previous studies of mainly sporadic narcolepsy support similar 
      disease mechanisms. We also report novel allelic associations. Associations 
      between HLA-C and sleep parameters were seen independent of NT1 diagnosis, 
      supporting involvement of HLA-C in sleep subphenotypes.
CI  - (c) Sleep Research Society 2019. Published by Oxford University Press on behalf of 
      the Sleep Research Society. All rights reserved. For permissions, please e-mail 
      journals.permissions@oup.com.
FAU - Juvodden, Hilde T
AU  - Juvodden HT
AD  - Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias 
      (NevSom), Department of Rare Disorders, Oslo University Hospital, Ulleval, 
      Norway, Norway.
AD  - Institute of Clinical Medicine, University of Oslo, Norway.
FAU - Viken, Marte K
AU  - Viken MK
AD  - Department of Immunology, Oslo University Hospital, Rikshospitalet, Norway.
FAU - Nordstrand, Sebjorg E H
AU  - Nordstrand SEH
AD  - Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias 
      (NevSom), Department of Rare Disorders, Oslo University Hospital, Ulleval, 
      Norway, Norway.
AD  - Institute of Clinical Medicine, University of Oslo, Norway.
FAU - Viste, Rannveig
AU  - Viste R
AD  - Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias 
      (NevSom), Department of Rare Disorders, Oslo University Hospital, Ulleval, 
      Norway, Norway.
AD  - Institute of Clinical Medicine, University of Oslo, Norway.
FAU - Westlye, Lars T
AU  - Westlye LT
AD  - NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, 
      Norway.
AD  - Department of Psychology, University of Oslo, Norway.
FAU - Thorsby, Per M
AU  - Thorsby PM
AD  - Hormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, 
      Aker, Norway Norway.
FAU - Lie, Benedicte A
AU  - Lie BA
AD  - Department of Immunology, Oslo University Hospital, Rikshospitalet, Norway.
AD  - Department of Medical Genetics, University of Oslo and Oslo University Hospital, 
      Norway.
FAU - Knudsen-Heier, Stine
AU  - Knudsen-Heier S
AD  - Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias 
      (NevSom), Department of Rare Disorders, Oslo University Hospital, Ulleval, 
      Norway, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
RN  - 0 (HLA-DQ beta-Chains)
SB  - IM
MH  - Alleles
MH  - Genotype
MH  - HLA-DQ beta-Chains/genetics
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - *Narcolepsy/genetics
MH  - Sleep/genetics
OTO - NOTNLM
OT  - H1N1-vaccination
OT  - HLA
OT  - hypnagogic hallucinations
OT  - hypocretin
OT  - narcolepsy
OT  - sleep paralysis
EDAT- 2019/10/14 06:00
MHDA- 2021/04/15 06:00
CRDT- 2019/10/14 06:00
PHST- 2019/05/03 00:00 [received]
PHST- 2019/09/06 00:00 [revised]
PHST- 2019/10/14 06:00 [pubmed]
PHST- 2021/04/15 06:00 [medline]
PHST- 2019/10/14 06:00 [entrez]
AID - 5586722 [pii]
AID - 10.1093/sleep/zsz239 [doi]
PST - ppublish
SO  - Sleep. 2020 Mar 12;43(3):zsz239. doi: 10.1093/sleep/zsz239.