PMID- 31608502
OWN - NLM
STAT- MEDLINE
DCOM- 20201111
LR  - 20201111
IS  - 1099-1166 (Electronic)
IS  - 0885-6230 (Linking)
VI  - 35
IP  - 1
DP  - 2020 Jan
TI  - Depression but not frailty contributed to a higher risk for all-cause 
      hospitalizations in male older veterans.
PG  - 37-44
LID - 10.1002/gps.5212 [doi]
AB  - INTRODUCTION: Frailty is a state of vulnerability to stressors resulting in 
      higher morbidity, mortality, and utilization in older adults. Depression and 
      frailty often coexist, suggesting a bidirectional relationship that may increase 
      the effects of each individual condition on clinical outcomes and health-care 
      utilization in older adults. OBJECTIVE: To determine the effects of concurrent 
      frailty and depression on all-cause hospitalizations. METHODS/DESIGN: Prospective 
      cohort study, conducted at a Veterans Affairs (VA) Medical Center. The 
      participants were male, community-dwelling veterans 65 years and older. From 4 
      January through 30 December 2016, a 46-item frailty index was generated from data 
      obtained from the VA electronic health record. Trained staff conducted in-depth 
      reviews of electronic health records ascertaining depression status. Patients 
      were followed through 31 December 2017 for all-cause hospitalizations following 
      the initial assessment of frailty. After adjusting for covariates, the 
      association of frailty and depression with all-cause hospitalizations was 
      determined with the Andersen-Gill model, accounting for repeated 
      hospitalizations. RESULTS: Five hundred fifty-three male patients were part of 
      the study, mean age 76.3 (SD = 8.2) years. One hundred eighty-one patients 
      (32.7%) had depression diagnoses. During a median follow-up period of 530 days 
      (interquartile range [IQR] = 245), 123 patients (22.2%) had 240 hospitalizations. 
      Frailty status was not associated with future hospitalizations (adjusted hazard 
      ratio [HR] = 1.61; 95% CI, 95-2.74; P > .05). Depression was associated with 
      higher all-cause hospitalizations (adjusted HR = 1.57; 95% CI, 1.09-2.26); 
      P = .0157). CONCLUSIONS: Depression but not frailty was significantly associated 
      with higher rates of all-cause hospitalization. Implementing interventions that 
      target older adults with both frailty and depression may reduce the burden of 
      both conditions and reduce hospitalizations.
CI  - Published 2019. This article is a U.S. Government work and is in the public 
      domain in the USA.
FAU - Ruiz, Jorge G
AU  - Ruiz JG
AUID- ORCID: 0000-0003-3069-8502
AD  - Miami VA Healthcare System Geriatric Research, Education and Clinical Center 
      (GRECC), Miami, FL.
AD  - Miller School of Medicine, University of Miami, Miami, FL.
FAU - Rodriguez-Suarez, Mercedes
AU  - Rodriguez-Suarez M
AD  - Miller School of Medicine, University of Miami, Miami, FL.
AD  - Mental Health Service, Miami VA Healthcare System, Miami, FL.
FAU - Tang, Fei
AU  - Tang F
AD  - Research Service, Miami VA Healthcare System, Miami, FL.
FAU - Aparicio-Ugarriza, Raquel
AU  - Aparicio-Ugarriza R
AUID- ORCID: 0000-0001-7342-5972
AD  - Miami VA Healthcare System Geriatric Research, Education and Clinical Center 
      (GRECC), Miami, FL.
AD  - Miller School of Medicine, University of Miami, Miami, FL.
FAU - Ferri-Guerra, Juliana
AU  - Ferri-Guerra J
AUID- ORCID: 0000-0002-8437-9817
AD  - Miami VA Healthcare System Geriatric Research, Education and Clinical Center 
      (GRECC), Miami, FL.
AD  - Miller School of Medicine, University of Miami, Miami, FL.
FAU - Mohammed, Nadeem Y
AU  - Mohammed NY
AUID- ORCID: 0000-0003-0547-1154
AD  - Miami VA Healthcare System Geriatric Research, Education and Clinical Center 
      (GRECC), Miami, FL.
AD  - Miller School of Medicine, University of Miami, Miami, FL.
FAU - Mintzer, Michael J
AU  - Mintzer MJ
AUID- ORCID: 0000-0001-5789-172X
AD  - Miami VA Healthcare System Geriatric Research, Education and Clinical Center 
      (GRECC), Miami, FL.
AD  - Miller School of Medicine, University of Miami, Miami, FL.
AD  - Herbert Wertheim College of Medicine, Florida International University, Miami, 
      FL.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20191024
PL  - England
TA  - Int J Geriatr Psychiatry
JT  - International journal of geriatric psychiatry
JID - 8710629
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Depression/*epidemiology
MH  - Frail Elderly/statistics & numerical data
MH  - Frailty/*epidemiology
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Independent Living
MH  - Male
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Veterans/*psychology/*statistics & numerical data
OTO - NOTNLM
OT  - depression
OT  - frailty
OT  - hospitalization
OT  - older adults
OT  - veterans
EDAT- 2019/10/15 06:00
MHDA- 2020/11/12 06:00
CRDT- 2019/10/15 06:00
PHST- 2019/03/21 00:00 [received]
PHST- 2019/09/15 00:00 [accepted]
PHST- 2019/10/15 06:00 [pubmed]
PHST- 2020/11/12 06:00 [medline]
PHST- 2019/10/15 06:00 [entrez]
AID - 10.1002/gps.5212 [doi]
PST - ppublish
SO  - Int J Geriatr Psychiatry. 2020 Jan;35(1):37-44. doi: 10.1002/gps.5212. Epub 2019 
      Oct 24.